Novel small molecular dye-loaded lipid nanoparticles with efficient near-infrared-II absorption for photoacoustic imaging and photothermal therapy of hepatocellular carcinoma

2019 ◽  
Vol 7 (8) ◽  
pp. 3165-3177 ◽  
Author(s):  
Qingshan Chen ◽  
Jingqin Chen ◽  
Mu He ◽  
Yuanyuan Bai ◽  
Huixiang Yan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Diagnosis ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Lipid Nanoparticles ◽  
Diagnosis And Treatment

The NIR-II PA and PTT nanoparticle based on the IR-1061 dye would benefit early diagnosis and treatment of HCC.

Theranostics of Gold Nanoparticles with an Emphasis on Photoacoustic Imaging and Photothermal Therapy

2018 ◽  
Vol 24 (23) ◽  
pp. 2719-2728 ◽  
Author(s):  
Yi Liu ◽  
Wenhui Ma ◽  
Jing Wang
Keyword(s):  
Gold Nanoparticles ◽  
Temperature Control ◽  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Chemical Characteristics ◽  
Nir Light ◽  
Physical And Chemical

Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends.

scholarly journals A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

2021 ◽  
Vol 7 (12) ◽  
pp. eabe3588
Author(s):  
Shulong Wang ◽  
Liangliang Zhang ◽  
Jingjin Zhao ◽  
Min He ◽  
Yong Huang ◽  
...  
Keyword(s):  
Absorption Spectrum ◽  
Tumor Microenvironment ◽  
Redox Reaction ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Induced Absorption

Tumor microenvironment–responsive therapy has enormous application potential in the diagnosis and treatment of cancer. The glutathione (GSH) level has been shown to be significantly increased in tumor tissues. Thus, GSH can be used as an effective endogenous molecule for diagnosis and tumor microenvironment–activated therapy. In this study, we prepared a tumor microenvironment–induced, absorption spectrum red-shifted, iron-copper co-doped polyaniline nanoparticle (Fe-Cu@PANI). The Cu(II) in this nanoparticle can undergo a redox reaction with GSH in tumors. The redox reaction induces a red shift in the absorption spectrum of the Fe-Cu@PANI nanoparticles from the visible to the near-infrared region accompanying with the etching of this nanoparticle, which simultaneously activates tumor photoacoustic imaging and photothermal therapy, thereby improving the accuracy of in vivo tumor imaging and the efficiency of photothermal therapy. The nanoparticle prepared in this study has broad application prospects in the diagnosis and treatment of cancer.

Multifunctional targeted nanoprobe with high NIR-II PAI/MRI performance for precise theranostics of orthotopic early-stage hepatocellular carcinoma

2021 ◽  
Author(s):  
Linyun He ◽  
Yachao Zhang ◽  
Jiangbo Chen ◽  
Gongyuan Liu ◽  
Jingyi Zhu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Resonance ◽  
Early Diagnosis ◽  
Effective Treatment ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Early Stage ◽  
Resonance Imaging ◽  
Infrared Window

Early diagnosis and effective treatment of hepatocellular carcinoma (HCC) is quite critical for improving patients’ prognosis. The combination of second near-infrared window photoacoustic imaging (NIR-II PAI) and T2-magnetic resonance imaging...

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

2020 ◽  
Vol 6 (33) ◽  
pp. eaba3546 ◽  
Author(s):  
Xuan Yi ◽  
Hailin Zhou ◽  
Yu Chao ◽  
Saisai Xiong ◽  
Jing Zhong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Immune Checkpoint Blockade ◽  
Immune Memory ◽  
Immunotherapy Of Cancer ◽  
Rapid Clearance ◽  
Inhibit Tumor Metastasis

We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.

Glypican-3 (GPC3) targeted Fe3O4 core/Au shell nanocomplex for fluorescence/MRI/photoacoustic imaging-guided tumor photothermal therapy

2019 ◽  
Vol 7 (12) ◽  
pp. 5258-5269 ◽  
Author(s):  
Rui Tian ◽  
Lei Zhu ◽  
Zainen Qin ◽  
Guohao Wang ◽  
Jingjing Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Mri Imaging ◽  
Fe3o4 Core

PA/FI/MRI imaging guided Glypican-3 targeted hepatocellular carcinoma photothermal therapy mediated by Fe3O4 Core/Au shell nanocomplex.

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