Efficient synthesis of amino acid polymers for protein stabilization

2019 ◽  
Vol 7 (9) ◽  
pp. 3675-3682 ◽  
Author(s):  
Bing Li ◽  
Yueming Wu ◽  
Wenjing Zhang ◽  
Si Zhang ◽  
Ning Shao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Aggregation ◽  
Protein Stabilization ◽  
Efficient Synthesis ◽  
Amino Acid Polymers

Poly-l-glutamate exerts substantial protein stabilization during lyophilization by preventing protein aggregation.

scholarly journals Translational Selection and Yeast Proteome Evolution

Genetics ◽  
2003 ◽  
Vol 164 (4) ◽  
pp. 1291-1303 ◽  
Author(s):  
Hiroshi Akashi
Keyword(s):  
Natural Selection ◽  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Synonymous Codon ◽  
Amino Acid Usage ◽  
Proper Function ◽  
Efficient Synthesis ◽  
Expression Levels ◽  
Speed And Accuracy

AbstractThe primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptides reflects natural selection to optimize the speed and accuracy of translation. Strong relationships between synonymous codon usage bias and estimates of transcript abundance suggest that DNA array data serve as adequate predictors of translation rates. Amino acid usage also shows striking relationships with expression levels. Stronger correlations between tRNA concentrations and amino acid abundances among highly expressed proteins than among less abundant proteins support adaptation of both tRNA abundances and amino acid usage to enhance the speed and accuracy of protein synthesis. Natural selection for efficient synthesis appears to also favor shorter proteins as a function of their expression levels. Comparisons restricted to proteins within functional classes are employed to control for differences in amino acid composition and protein size that reflect differences in the functional requirements of proteins expressed at different levels.

ChemInform Abstract: Efficient Synthesis of Modular Amino Acid Derivatives Containing Selenium with Pronounced GPx-Like Activity.

ChemInform ◽  
2010 ◽  
Vol 41 (3) ◽  
Author(s):  
Eduardo E. Alberto ◽  
Letiere C. Soares ◽  
Jessie H. Sudati ◽  
Antonio C. A. Borges ◽  
Joao B. T. Rocha ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Efficient Synthesis

scholarly journals An Efficient Synthesis of Novel Adamantane β-Amino Acid: 2-(Adamant-2-yl)-3-aminopropanoic Acid

2012 ◽  
Vol 85 (4) ◽  
pp. 419-423 ◽  
Author(s):  
Vesna Petrović Peroković ◽  
Rosana Ribić ◽  
Biserka Prugovečki ◽  
Dubravka Matković-Čalogović ◽  
Srđanka Tomić
Keyword(s):  
Amino Acid ◽  
Efficient Synthesis

scholarly journals Tandem four-component reaction for efficient synthesis of dihydrothiophene with substituted amino acid ethyl esters

RSC Advances ◽  
2018 ◽  
Vol 8 (40) ◽  
pp. 22498-22505 ◽  
Author(s):  
Jing Sun ◽  
Yu Zhang ◽  
Chao-Guo Yan
Keyword(s):  
Amino Acid ◽  
Aromatic Aldehydes ◽  
Ethyl Esters ◽  
Efficient Synthesis ◽  
One Pot ◽  
The One

The one-pot four-component reaction of aromatic aldehydes, malononitrile, 1,3-thiazolidinedione and ethyl glycinate hydrochloride in ethanol in the presence of triethylamine afforded trans-dihydrothiophene.

scholarly journals Synthesis of the Tripeptide Antibiotic Resormycin

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5351-5356 ◽  
Author(s):  
Loana Musso ◽  
Rahul Kaduskar ◽  
Andrea Pinto ◽  
Leonardo Scaglioni ◽  
Sabrina Dallavalle
Keyword(s):  
Amino Acid ◽  
Antifungal Activity ◽  
Late Stage ◽  
Biological Evaluation ◽  
Synthetic Approach ◽  
Efficient Synthesis ◽  
Hydroxy Amino Acid ◽  
Streptomyces Platensis ◽  
Hydroxy Amino ◽  
Modular Nature

A short and efficient synthesis of resormycin, a metabolite of Streptomyces platensis MJ953-SF5 with herbicidal and antifungal activity, is described. The key step in our synthetic approach is a late-stage stereospecific dehydration of a β-hydroxy amino acid to install the Z-olefin. Because of the modular nature of the synthesis, access to analogues for biological evaluation is readily available.

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