scholarly journals Integrated wax valve for robust fluid control in an electrochemical fabric-based device

2019 ◽  
Vol 11 (40) ◽  
pp. 5098-5107 ◽  
Author(s):  
Corey Downs ◽  
Arianna Nejely ◽  
Elain Fu

We present a wax-based valve as a novel approach for fluid control in fabric-based microfluidic devices.

Inventions ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 20 ◽  
Author(s):  
E. Strong ◽  
Carsten Knutsen ◽  
Jay Wells ◽  
Aditya Jangid ◽  
Megan Mitchell ◽  
...  

Microfluidic paper-based analytical devices (microPADs) have emerged as a promising platform for point-of-care diagnostic devices. While the inherent wicking properties of microPADs allow for fluid flow without supporting equipment, this also presents a major challenge in achieving robust fluid control, which becomes especially important when performing complex multi-step assays. Herein, we describe an ideal method of fluid control mediated by wax-printed fluidic time delays. This method relies on a simple fabrication technique, does not utilize chemicals/reagents that could affect downstream assays, is readily scalable, and has a wide temporal range of tunable fluid control. The delays are wax printed on both the top and bottom of pre-fabricated microPAD channels, without subsequent heating, to create hemi-/fully-enclosed channels. With these wax printed delays, we were able to tune the time it took aqueous solutions to wick across a 25 mm-long channel between 3.6 min and 13.4 min. We then employed these fluid delays in the sequential delivery of four dyes to a test zone. Additionally, we demonstrated the automation of two simple enzymatic assays with this fluid control modality. This method of fluid control may allow future researchers to automate more complex assays, thereby further advancing microPADs toward real-world applications.


2007 ◽  
Vol 79 (19) ◽  
pp. 7485-7491 ◽  
Author(s):  
Margaret A. Lerch ◽  
Stephen C. Jacobson

2016 ◽  
Vol 24 (06) ◽  
pp. 1750075 ◽  
Author(s):  
SUBHADEEP MUKHOPADHYAY

In this research paper, total 246 individual microfluidic devices have been fabricated by maskless lithography, hot embossing lithography and direct bonding technique. The effect of surface area to volume ratio on the surface-driven capillary flow of different liquids has been experimentally investigated in these microfluidic devices fabricated by polymethylmethacrylate (PMMA). Also, the individual effects of liquid viscosity and surface wettability on the surface-driven capillary flow of different liquids are experimentally investigated. The polystyrene particles of 10[Formula: see text][Formula: see text]m diameters have been separated from the aqueous microparticle suspensions in the microfluidic lab-on-a-chip systems with 100% separation efficiency. Also, the polystyrene particles of 5[Formula: see text][Formula: see text]m diameters have been separated from a different set of aqueous microparticle suspensions in the microfluidic lab-on-a-chip systems with 100% separation efficiency. The individual designs of the microfluidic lab-on-a-chip systems are a novel approach in this research paper. The effect of surface area to volume ratio on the separation time is experimentally investigated as another novel approach of this research paper.


2014 ◽  
Vol 2014 (1) ◽  
pp. 000516-000521
Author(s):  
Lilla Safford Smith ◽  
Gordon D. Hoople ◽  
Jim C. Cheng ◽  
Albert P. Pisano

Recent efforts have lead to the development of a silicon microfluidic cooling device known as the micro-Columnated Loop Heat Pipe (μCLHP) [1] [2] [3] . The μCLHP, like a traditional heat pipe, utilizes phase change of a liquid to rapidly draw heat away from a concentrated hot spot. Proper hermetic packaging of this device is critical for the reliable testing of the recirculating fluid. This work presents a novel approach to filling and hermetically sealing the μCLHP. A miniature valve (Beswick M3SV-N) is bonded to the silicon fill ports of the μCLHP. The use of a resealable valve, as opposed to a permanent sealing method, allows the device to be filled, sealed, and then evacuated for testing with different fluids and at multiple pressures. Building on work by Murphy [4], the fill ports on the μCLHP were metalized with a 10nm Cr - 200 nm Ni - 10 nm Au stack. Then a lead based solder was used to bond the stainless steel adapter to the metalized layers. Hermeticity testing of devices sealed using these miniature valves demonstrated average hourly percent weight losses between 0.170 % – 0.821 %. While this bonding method has been developed specifically for the μCLHP, it is broadly applicable to most ceramic microfluidic devices, especially those fabricated from silicon and glass. Due to the time intensive manufacturing process of microfluidic devices made from these hard materials, a novel, robust, resealing method that allows reuse of a single silicon microfluidic device for multiple test conditions is highly desirable.


2015 ◽  
Vol 12 (1) ◽  
pp. 49-54
Author(s):  
Lilla Safford Smith ◽  
Gordon D. Hoople ◽  
Jim C. Cheng ◽  
Albert P. Pisano

Recent efforts have led to the development of a silicon microfluidic cooling device known as the microcolumnated loop heat pipe (μCLHP). The μCLHP, like a traditional heat pipe, utilizes phase change of a liquid to rapidly draw heat away from a concentrated hot spot. Proper gas-tight packaging of this device is critical for the reliable testing of the recirculating fluid. This work presents a novel approach to filling and sealing the μCLHP. A miniature valve (Beswick M3SV-N) is bonded to the silicon fill ports of the μCLHP. The use of a resealable valve, as opposed to a permanent sealing method, allows the device to be filled, sealed, and then evacuated for testing with different fluids and at multiple pressures. Building on earlier work, the fill ports on the μCLHP were metalized with a Cr (10 nm)/Ni (200 nm)/Au (10 nm) stack. Then a lead-based solder was used to bond the stainless steel adapter to the metalized layers. Leak testing of devices sealed using these miniature valves demonstrated average hourly percent weight losses between 0.17% and 0.82%. While this bonding method has been developed specifically for the μCLHP, it is broadly applicable to most ceramic microfluidic devices, especially those fabricated from silicon and glass. Due to the time-intensive manufacturing process of microfluidic devices made from these hard materials, a novel, robust, resealing method that allows reuse of a single silicon microfluidic device for multiple test conditions is highly desirable.


2017 ◽  
Vol 24 (03) ◽  
pp. 1750041 ◽  
Author(s):  
SUBHADEEP MUKHOPADHYAY ◽  
JYOTI PRASAD BANERJEE ◽  
SUSANTA SINHA ROY ◽  
SANJEEV KUMAR METYA ◽  
MARK TWEEDIE ◽  
...  

In this research paper, in total 212 individual leakage-free Polymethylmethacrylate (PMMA) microfluidic devices are fabricated by maskless lithography, hot embossing lithography and direct bonding technique. The effect of channel aspect ratio on dyed water flow is investigated using these microfluidic devices. Experimental studies show that the dyed water flow is faster on the surface of higher wettability. The effect of capillary pressure on dyed water flow is studied in the fabricated PMMA microfluidic devices. According to the experimental observations, the centrifugal force has prominent effect on the dyed water flow. Also, the effect of bend angle is investigated on the surface-driven capillary flow of water. The polystyrene microparticles have been separated in the microfluidic lab-on-a-chip systems using the investigated flow features. A 100% separation efficiency is achieved in these lab-on-a-chip systems. These microfluidic lab-on-a-chip systems can be used to separate blood cells from human whole blood for further clinical tests. These experimental studies are important in bioengineering applications. The effect of bend angle as channel geometry to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems. Also, the effect of surface wettability as surface property to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems.


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