scholarly journals Advances in nanoplasmonic biosensors for clinical applications

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7105-7129 ◽  
Author(s):  
Elba Mauriz ◽  
Priyanka Dey ◽  
Laura M. Lechuga
Keyword(s):  
Clinical Outcomes ◽  
Point Of Care ◽  
Cost Effective ◽  
Clinical Applications ◽  
Point Of Care Testing ◽  
The Way

Plasmonic biosensors can be conveniently used as portable diagnostic devices for attaining timely and cost-effective clinical outcomes. Nanoplasmonics technology opens the way for sensor miniaturization, multiplexing and point of care testing.

Paper-based point-of-care testing for cost-effective diagnosis of acute dengue infections

2016 ◽  
Vol 82 ◽  
pp. S51
Author(s):  
F. Bedin ◽  
E. Voilin ◽  
L. Boulet ◽  
G. Theillet ◽  
A. Perrin ◽  
...  
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
Point Of Care Testing ◽  
Effective Diagnosis

scholarly journals Three-Dimensional Paper-Based Microfluidic Analysis Device for Simultaneous Detection of Multiple Biomarkers with a Smartphone

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 187
Author(s):  
Seung Ho Baek ◽  
Chanyong Park ◽  
Jaehyung Jeon ◽  
Sungsu Park
Keyword(s):  
Point Of Care ◽  
Simultaneous Detection ◽  
Three Dimensional ◽  
Cost Effective ◽  
Smartphone Application ◽  
Accurate Diagnosis ◽  
Point Of Care Testing ◽  
Digital Light Processing ◽  
Multiple Biomarkers ◽  
Microfluidic Analysis

Paper-based microfluidic analysis devices (μPADs) have attracted attention as a cost-effective platform for point-of-care testing (POCT), food safety, and environmental monitoring. Recently, three-dimensional (3D)-μPADs have been developed to improve the performance of μPADs. For accurate diagnosis of diseases, however, 3D-μPADs need to be developed to simultaneously detect multiple biomarkers. Here, we report a 3D-μPADs platform for the detection of multiple biomarkers that can be analyzed and diagnosed with a smartphone. The 3D-μPADs were fabricated using a 3D digital light processing printer and consisted of a sample reservoir (300 µL) connected to 24 detection zones (of 4 mm in diameter) through eight microchannels (of 2 mm in width). With the smartphone application, eight different biomarkers related to various diseases were detectable in concentrations ranging from normal to abnormal conditions: glucose (0–20 mmol/L), cholesterol (0–10 mmol/L), albumin (0–7 g/dL), alkaline phosphatase (0–800 U/L), creatinine (0–500 µmol/L), aspartate aminotransferase (0–800 U/L), alanine aminotransferase (0–1000 U/L), and urea nitrogen (0–7.2 mmol/L). These results suggest that 3D-µPADs can be used as a POCT platform for simultaneous detection of multiple biomarkers.

scholarly journals Cost-Effective Flexible CSRR-Based Sensor for Noninvasive Measurement of Permittivity of Biomaterials

2021 ◽  
Vol 10 (1) ◽  
pp. 26
Author(s):  
Faezeh Shanehsazzadeh ◽  
Nafise Azizi ◽  
Hosna Kazerooni Haghighat ◽  
Fatemeh Mashayekhi ◽  
Mehdi Fardmanesh
Keyword(s):  
Ring Resonator ◽  
Point Of Care ◽  
Cost Effective ◽  
Split Ring Resonator ◽  
Point Of Care Testing ◽  
Split Ring ◽  
Tissue Samples ◽  
Complementary Split Ring Resonator ◽  
Microwave Sensor ◽  
Wide Range

A novel, cost-effective, flexible microwave sensor is proposed to facilitate point-of-care testing (POCT) methods for medical diagnosis. The sensor is based on the complementary split-ring resonator (CSRR) to accurately measure the permittivity of biomaterials over a wide range of frequencies. This ability can be used to characterize various materials under test (MUT) such as blood, saliva, tissue samples, etc. The flexibility of the proposed sensor means that it can be used when the accessibility of the sample has technical difficulties, such as on curved surfaces. Firstly, the optimized structure and coupling to the readout transmission line are evaluated using finite element method (FEM) simulations. Then, the prototype of the optimized structure is fabricated on a thin polydimethylsiloxane (PDMS) substrate as a biocompatible economical polymer, and aluminium is carefully chosen for the fabrication of CSRR and readout parts. The proposed flexible sensor is tested and compared to conventional rigid CSRR sensors. The proposed structure withstood the different bending positions well, and also showed an improvement in the results for curved MUT.

scholarly journals Paper-based point-of-care testing for cost-effective diagnosis of acute flavivirus infections

2017 ◽  
Vol 89 (9) ◽  
pp. 1520-1527 ◽  
Author(s):  
Frederic Bedin ◽  
Laurent Boulet ◽  
Elodie Voilin ◽  
Gerald Theillet ◽  
Agnes Rubens ◽  
...  
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
Point Of Care Testing ◽  
Effective Diagnosis

Clinical Applications of Point-of-Care Testing in Different Conditions

2018 ◽  
Vol 64 (07+08/2018) ◽  
Author(s):  
Nairo Sumita ◽  
Carlos Ferreira ◽  
Marines Martino ◽  
Carolina Franca ◽  
Adriana Faulhaber ◽  
...  
Keyword(s):  
Point Of Care ◽  
Clinical Applications ◽  
Point Of Care Testing

Point-of-care testing INR: an overview

2017 ◽  
Vol 55 (6) ◽  
pp. 800-805 ◽  
Author(s):  
Doris Barcellona ◽  
Lara Fenu ◽  
Francesco Marongiu
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
International Normalized Ratio ◽  
Point Of Care Testing ◽  
Mechanical Valves ◽  
Self Testing ◽  
Periodic Monitoring ◽  
Monitoring Test ◽  
Pros And Cons

Abstract Oral anticoagulant therapies with the anti-vitamin K drugs (AVK), warfarin, acenocoumarol and phenprocoumon, are employed in primary and secondary anti-thrombotic prophylaxis in patients with venous thromboembolism, atrial fibrillation and cardiac mechanical valves. However, a monitoring test such as the International Normalized Ratio (INR) is required. The periodic monitoring of this therapy entails discomfort for the patients. Telemedicine and telecare can provide significant aid in the management of this therapy allowing patients to perform the test at home or anywhere else with a portable device, i.e. point-of-care testing (POCT), and to send the result to a thrombosis (TC) via web. Patients can receive dose adjustment sent back by the TC. The effectiveness of this type of management is equal or superior to the traditional AVK monitoring in terms of hemorrhagic and thrombotic events. Analysis of the costs with a horizon of 10 years reveals that both self-testing and self-management are cost-effective. The aim of this overview is to describe the pros and cons of the use of POCT as an alternative in the monitoring of AVK. In particular, description of the POCT, decentralization, quality of the therapy, safety and costs will be examined.

scholarly journals Ultrahigh Frequency Ultrasound Imaging of the Hand: A New Diagnostic Tool for Hand Surgery

Hand ◽  
2017 ◽  
Vol 13 (6) ◽  
pp. 720-725 ◽  
Author(s):  
Stephen L. Viviano ◽  
Laurel K. Chandler ◽  
Jonathan D. Keith
Keyword(s):  
Imaging Modality ◽  
Point Of Care ◽  
Hand Surgery ◽  
Cost Effective ◽  
Clinical Applications ◽  
Ultrahigh Frequency ◽  
Clinical Patient ◽  
Novel Technology ◽  
Conventional Ultrasound ◽  
Frequency Ultrasound

Background: Ultrasonography is a cost-effective, noninvasive, and expedient imaging modality with numerous clinical applications. Conventional ultrasound uses transducers with frequencies that range from 5 to 12 MHz. However, ultrahigh frequency ultrasound (UHFUS) is capable of producing frequencies up to 70 MHz, which can achieve tissue resolution up to 30 μm. The purpose of our study is to present the capabilities of a novel technology and to describe its possible clinical applications for hand surgery. Methods: The Vevo 2100 (VisualSonics, Toronto, Canada) system was used to perform all ultrasound exams. Four unique linear array transducers were employed. All studies were performed by the authors, who have no formal training in ultrasound techniques, on 5 healthy resident volunteers and 1 clinical patient under institutional review board approval. Results: A series of 10 static images per participant and dynamic, real-time videos were obtained at various locations within the hand and wrist. UHFUS is capable of quickly and reliably imaging larger structures such as foreign bodies, soft tissue masses, and the flexor tendons, and diagnosing an array of pathologies within these structures. In addition, UHFUS can identify much finer structures such as the intimal layer of the arteries in the hand and individual fascicles within the digital nerves to provide data about vessel quality and vascular and neural pathologies. Conclusions: UHFUS is a novel technology that shows multiple advantages over conventional ultrasound for imaging the fine superficial structures of the hand and wrist, and can be deployed by the surgeon at the point of care.

Sign in / Sign up

Export Citation Format

Share Document