scholarly journals Paper-based point-of-care testing for cost-effective diagnosis of acute flavivirus infections

2017 ◽  
Vol 89 (9) ◽  
pp. 1520-1527 ◽  
Author(s):  
Frederic Bedin ◽  
Laurent Boulet ◽  
Elodie Voilin ◽  
Gerald Theillet ◽  
Agnes Rubens ◽  
...  
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
Point Of Care Testing ◽  
Effective Diagnosis

Paper-based point-of-care testing for cost-effective diagnosis of acute dengue infections

2016 ◽  
Vol 82 ◽  
pp. S51
Author(s):  
F. Bedin ◽  
E. Voilin ◽  
L. Boulet ◽  
G. Theillet ◽  
A. Perrin ◽  
...  
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
Point Of Care Testing ◽  
Effective Diagnosis

scholarly journals Three-Dimensional Paper-Based Microfluidic Analysis Device for Simultaneous Detection of Multiple Biomarkers with a Smartphone

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 187
Author(s):  
Seung Ho Baek ◽  
Chanyong Park ◽  
Jaehyung Jeon ◽  
Sungsu Park
Keyword(s):  
Point Of Care ◽  
Simultaneous Detection ◽  
Three Dimensional ◽  
Cost Effective ◽  
Smartphone Application ◽  
Accurate Diagnosis ◽  
Point Of Care Testing ◽  
Digital Light Processing ◽  
Multiple Biomarkers ◽  
Microfluidic Analysis

Paper-based microfluidic analysis devices (μPADs) have attracted attention as a cost-effective platform for point-of-care testing (POCT), food safety, and environmental monitoring. Recently, three-dimensional (3D)-μPADs have been developed to improve the performance of μPADs. For accurate diagnosis of diseases, however, 3D-μPADs need to be developed to simultaneously detect multiple biomarkers. Here, we report a 3D-μPADs platform for the detection of multiple biomarkers that can be analyzed and diagnosed with a smartphone. The 3D-μPADs were fabricated using a 3D digital light processing printer and consisted of a sample reservoir (300 µL) connected to 24 detection zones (of 4 mm in diameter) through eight microchannels (of 2 mm in width). With the smartphone application, eight different biomarkers related to various diseases were detectable in concentrations ranging from normal to abnormal conditions: glucose (0–20 mmol/L), cholesterol (0–10 mmol/L), albumin (0–7 g/dL), alkaline phosphatase (0–800 U/L), creatinine (0–500 µmol/L), aspartate aminotransferase (0–800 U/L), alanine aminotransferase (0–1000 U/L), and urea nitrogen (0–7.2 mmol/L). These results suggest that 3D-µPADs can be used as a POCT platform for simultaneous detection of multiple biomarkers.

scholarly journals Cost-Effective Flexible CSRR-Based Sensor for Noninvasive Measurement of Permittivity of Biomaterials

2021 ◽  
Vol 10 (1) ◽  
pp. 26
Author(s):  
Faezeh Shanehsazzadeh ◽  
Nafise Azizi ◽  
Hosna Kazerooni Haghighat ◽  
Fatemeh Mashayekhi ◽  
Mehdi Fardmanesh
Keyword(s):  
Ring Resonator ◽  
Point Of Care ◽  
Cost Effective ◽  
Split Ring Resonator ◽  
Point Of Care Testing ◽  
Split Ring ◽  
Tissue Samples ◽  
Complementary Split Ring Resonator ◽  
Microwave Sensor ◽  
Wide Range

A novel, cost-effective, flexible microwave sensor is proposed to facilitate point-of-care testing (POCT) methods for medical diagnosis. The sensor is based on the complementary split-ring resonator (CSRR) to accurately measure the permittivity of biomaterials over a wide range of frequencies. This ability can be used to characterize various materials under test (MUT) such as blood, saliva, tissue samples, etc. The flexibility of the proposed sensor means that it can be used when the accessibility of the sample has technical difficulties, such as on curved surfaces. Firstly, the optimized structure and coupling to the readout transmission line are evaluated using finite element method (FEM) simulations. Then, the prototype of the optimized structure is fabricated on a thin polydimethylsiloxane (PDMS) substrate as a biocompatible economical polymer, and aluminium is carefully chosen for the fabrication of CSRR and readout parts. The proposed flexible sensor is tested and compared to conventional rigid CSRR sensors. The proposed structure withstood the different bending positions well, and also showed an improvement in the results for curved MUT.

Point-of-care testing INR: an overview

2017 ◽  
Vol 55 (6) ◽  
pp. 800-805 ◽  
Author(s):  
Doris Barcellona ◽  
Lara Fenu ◽  
Francesco Marongiu
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
International Normalized Ratio ◽  
Point Of Care Testing ◽  
Mechanical Valves ◽  
Self Testing ◽  
Periodic Monitoring ◽  
Monitoring Test ◽  
Pros And Cons

Abstract Oral anticoagulant therapies with the anti-vitamin K drugs (AVK), warfarin, acenocoumarol and phenprocoumon, are employed in primary and secondary anti-thrombotic prophylaxis in patients with venous thromboembolism, atrial fibrillation and cardiac mechanical valves. However, a monitoring test such as the International Normalized Ratio (INR) is required. The periodic monitoring of this therapy entails discomfort for the patients. Telemedicine and telecare can provide significant aid in the management of this therapy allowing patients to perform the test at home or anywhere else with a portable device, i.e. point-of-care testing (POCT), and to send the result to a thrombosis (TC) via web. Patients can receive dose adjustment sent back by the TC. The effectiveness of this type of management is equal or superior to the traditional AVK monitoring in terms of hemorrhagic and thrombotic events. Analysis of the costs with a horizon of 10 years reveals that both self-testing and self-management are cost-effective. The aim of this overview is to describe the pros and cons of the use of POCT as an alternative in the monitoring of AVK. In particular, description of the POCT, decentralization, quality of the therapy, safety and costs will be examined.

scholarly journals Point-of-care testing as the future of pre-hospital emergency medicine: an overview

2021 ◽  
Keyword(s):  
Emergency Medicine ◽  
Point Of Care ◽  
Cost Effective ◽  
Point Of Care Testing ◽  
Hospital Emergency ◽  
Management Guidelines ◽  
Inspection Errors ◽  
Advantages And Disadvantages ◽  
Point Of Care Tests ◽  
Total Compliance

Point-of-care testing (POCT) plays an increasingly important role in pre-emergency medicine by ensuring that patient’s continuum of care is commenced before arrival at health facilities. Given the benefits of POCT during the COVID-19 pandemic, this commentary described the advantages and disadvantages of POCT, and its current practices in pre-hospital emergency medicine. Point-of-care tests are easy to operate, cost-effective, and yield quick and accurate response, but are posed with challenges such as safety errors, poor adherence to quality control standards, and inspection errors. To optimize the benefits of POCT in pre-emergency medicine, it is required that regular trainings are conducted for POCT operators, and total compliance to POCT handling and management guidelines should be considered by each POCT operator.

scholarly journals Three-Dimensional Paper-Based Microfluidic Analysis Device for Simultaneous Detection of Multiple Biomarkers With a Smartphone

2020 ◽  
Author(s):  
Seung Ho Baek ◽  
Chanyong Park ◽  
Jaehyung Jeon ◽  
Sungsu Park
Keyword(s):  
Point Of Care ◽  
Simultaneous Detection ◽  
Three Dimensional ◽  
Cost Effective ◽  
Smartphone Application ◽  
Accurate Diagnosis ◽  
Point Of Care Testing ◽  
Digital Light Processing ◽  
Multiple Biomarkers ◽  
Microfluidic Analysis

Paper-based microfluidic analysis devices (μPADs) have attracted attention as a cost-effective platform for point-of-care testing (POCT), food safety, and environmental monitoring. Recently, three-dimensional (3D)-μPADs have been developed to improve the performance of μPADs. For accurate diagnosis of diseases, however, 3D-μPADs need to be developed to simultaneously detect multiple biomarkers. Here, we report a 3D-μPADs platform for the detection of multiple biomarkers that can be analyzed and diagnosed with a smartphone. The 3D-μPADs were fabricated using a 3D digital light processing printer and consisted of a sample reservoir (300 µL) connected to 24 detection zones (of 4 mm in diameter) through 8 microchannels (of 2 mm in width). With the smartphone application, eight different biomarkers related to various diseases were detectable in concentrations ranging from normal to abnormal conditions: glucose (0–20 mmol/L), cholesterol (0–10 mmol/L), albumin (0–7 g/dL), alkaline phosphatase (0–800 U/L), creatinine (0–500 µmol/L), aspartate aminotransferase (0–800 U/L), alanine aminotransferase (0–1000 U/L), and urea nitrogen (0–7.2 mmol/L). These results suggest that 3D-µPADs can be used as a POCT platform for simultaneous detection of multiple biomarkers.

scholarly journals A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2

2020 ◽  
Author(s):  
Daniel J Brogan ◽  
Duverney Chaverra-Rodriguez ◽  
Calvin P Lin ◽  
Andrea L Smidler ◽  
Ting Yang ◽  
...  
Keyword(s):  
Public Health ◽  
Nucleic Acid ◽  
Point Of Care ◽  
Cost Effective ◽  
Molecular Diagnostic ◽  
Emerging Pathogens ◽  
Public Health Importance ◽  
Point Of Care Diagnostics ◽  
Effective Diagnosis ◽  
Critical Public Health

AbstractSince its first emergence from China in late 2019, the SARS-CoV-2 virus has spread globally despite unprecedented containment efforts, resulting in a catastrophic worldwide pandemic. Successful identification and isolation of infected individuals can drastically curtail virus spread and limit outbreaks. However, during the early stages of global transmission, point-of-care diagnostics were largely unavailable and continue to remain difficult to procure, greatly inhibiting public health efforts to mitigate spread. Furthermore, the most prevalent testing kits rely on reagent- and time-intensive protocols to detect viral RNA, preventing rapid and cost-effective diagnosis. Therefore the development of an extensive toolkit for point-of-care diagnostics that is expeditiously adaptable to new emerging pathogens is of critical public health importance. Recently, a number of novel CRISPR-based diagnostics have been developed to detect COVID-19. Herein, we outline the development of a CRISPR-based nucleic acid molecular diagnostic utilizing a Cas13d ribonuclease derived from Ruminococcus flavefaciens (CasRx) to detect SARS-CoV-2, an approach we term SENSR (Sensitive Enzymatic Nucleic-acid Sequence Reporter). We demonstrate SENSR robustly detects SARS-CoV-2 sequences in both synthetic and patient-derived samples by lateral flow and fluorescence, thus expanding the available point-of-care diagnostics to combat current and future pandemics.

scholarly journals Advances in nanoplasmonic biosensors for clinical applications

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7105-7129 ◽  
Author(s):  
Elba Mauriz ◽  
Priyanka Dey ◽  
Laura M. Lechuga
Keyword(s):  
Clinical Outcomes ◽  
Point Of Care ◽  
Cost Effective ◽  
Clinical Applications ◽  
Point Of Care Testing ◽  
The Way

Plasmonic biosensors can be conveniently used as portable diagnostic devices for attaining timely and cost-effective clinical outcomes. Nanoplasmonics technology opens the way for sensor miniaturization, multiplexing and point of care testing.

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