Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(iv) prodrug for enhanced anticancer therapy

2019 ◽  
Vol 7 (11) ◽  
pp. 1867-1874 ◽  
Author(s):  
Shu-Wen Shi ◽  
Yan-Hui Li ◽  
Qian-Ling Zhang ◽  
Shi-Ping Yang ◽  
Jin-Gang Liu
Keyword(s):  
Nitric Oxide ◽  
Photothermal Therapy ◽  
Anticancer Therapy ◽  
Controlled Delivery ◽  
Light Irradiation ◽  
Nir Light

A multifunctional nanoplatform exhibits selective intracellular co-delivery of Pt(ii) and NO under 808 nm light irradiation, accompanied by photothermal therapy.

A ruthenium-nitrosyl-functionalized nanoplatform for the targeting of liver cancer cells and NIR-light-controlled delivery of nitric oxide combined with photothermal therapy

2017 ◽  
Vol 5 (38) ◽  
pp. 7831-7838 ◽  
Author(s):  
Yan-Hui Li ◽  
Min Guo ◽  
Shu-Wen Shi ◽  
Qian-Ling Zhang ◽  
Shi-Ping Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Controlled Delivery ◽  
Liver Cancer Cells ◽  
Ruthenium Nitrosyl ◽  
Nir Light ◽  
No Release

A multifunctional nanoplatform is capable of targeting liver cancer cells for NIR-light-controlled NO-release, and achieving both photodynamic and photothermal therapies.

A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

2018 ◽  
Vol 54 (100) ◽  
pp. 14108-14111 ◽  
Author(s):  
Kangqiang Qiu ◽  
Jinquan Wang ◽  
Thomas W. Rees ◽  
Liangnian Ji ◽  
Qianling Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Light Irradiation ◽  
Nir Light ◽  
Mri Guided ◽  
Mitochondria Targeting

A mitochondria-targeting photothermogenic nanozyme was used to increase localized temperature and accelerate the catalysis of H2O2 to ˙OH under NIR light irradiation for mild photothermal therapy.

A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

2016 ◽  
Vol 4 (27) ◽  
pp. 4667-4674 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Min Guo ◽  
Lu An ◽  
Shi-Ping Yang ◽  
Qian-Ling Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized.

Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy

2018 ◽  
Vol 6 (48) ◽  
pp. 8148-8162 ◽  
Author(s):  
Qi Cai ◽  
Jiating Xu ◽  
Dan Yang ◽  
Yunlu Dai ◽  
Guixin Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Light Irradiation ◽  
Nir Light

Under 980 nm light irradiation, polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposites can convert NIR light to achieve both photodynamic therapy (PDT) and photothermal therapy (PTT).

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

2017 ◽  
Vol 53 (22) ◽  
pp. 3253-3256 ◽  
Author(s):  
Min Guo ◽  
Hui-Jing Xiang ◽  
Yi Wang ◽  
Qian-Ling Zhang ◽  
Lu An ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Quantum Dots ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Graphene Quantum Dots ◽  
Antitumor Efficacy ◽  
Functionalized Graphene ◽  
Ruthenium Nitrosyl ◽  
Nir Light

Targeted delivery of NO accompanied by photothermal therapy shows efficient in vivo antitumor efficacy.

Modulation of oxygen vacancy in tungsten oxide nanosheets for Vis-NIR light-enhanced electrocatalytic hydrogen production and anticancer photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18183-18190 ◽  
Author(s):  
Haiyan Liang ◽  
Hongjuan Xi ◽  
Shaoqiong Liu ◽  
Xuemei Zhang ◽  
Haiqing Liu
Keyword(s):  
Hydrogen Production ◽  
Oxygen Vacancy ◽  
Tungsten Oxide ◽  
Hydrogen Evolution ◽  
Noble Metal ◽  
Photothermal Therapy ◽  
Light Irradiation ◽  
Nir Light

Noble-metal like photoelectrocatalytic hydrogen evolution and efficient anticancer photothermal therapy were accomplished by simply tuning the oxygen vacancy of WO3 nanosheets under Vis-NIR light irradiation.

scholarly journals GE11 Peptide Conjugated Liposomes for EGFR-Targeted and Chemophotothermal Combined Anticancer Therapy

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Xueqin Huang ◽  
Lingzhi Chen ◽  
Yuping Zhang ◽  
Suyan Zhou ◽  
Huai-Hong Cai ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Growth Factor Receptor ◽  
Anticancer Therapy ◽  
Ros Generation ◽  
Nir Light ◽  
Controllable Release ◽  
Cytoskeleton Disruption ◽  
Cell Inhibition

How to actively target tumor sites manipulating the controllable release of the encapsulated anticancer drugs and photosensitizers for synergistic anticancer therapy remains a big challenge. In this study, a cancer cell-targeted, near-infrared (NIR) light-triggered and anticancer drug loaded liposome system (LPs) was developed for synergistic cancer therapy. Photosensitizer indocyanine green (ICG) and chemotherapy drug Curcumin (CUR) were coencapsulated into the liposomes, followed by the surface conjugation of GE11 peptide for epidermal growth factor receptor (EGFR) targeting on the cancer cell surface. Strictly controlled by NIR light, GE11 peptide modified and CUR/ICG-loaded LPs (GE11-CUR/ICG-LPs) could introduce hyperthermia in EGFR overexpressed A549 cancer cells for photothermal therapy, which could also trigger the increased release of CUR for enhanced cancer cell inhibition. GE11-CUR/ICG-LPs synergized photochemotherapy could induce reactive oxygen species (ROS) generation and cytoskeleton disruption to activate stronger apoptotic signaling events than the photothermal therapy or chemotherapy alone by regulating Bax/Bcl-2 and PI3K/AKT pathways. This EGFR-targeted drug-delivery nanosystem with NIR sensitivity may potentially serve in more effective anticancer therapeutics with reduced off-target effects.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

scholarly journals Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 756
Author(s):  
Manoj Kumar Mahata ◽  
Ranjit De ◽  
Kang Taek Lee
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cutting Edge ◽  
Clinical Translation ◽  
Basic Knowledge ◽  
Nanotechnology Research ◽  
Nir Light

Due to the unique properties of lanthanide-doped upconverting nanoparticles (UCNP) under near-infrared (NIR) light, the last decade has shown a sharp progress in their biomedicine applications. Advances in the techniques for polymer, dye, and bio-molecule conjugation on the surface of the nanoparticles has further expanded their dynamic opportunities for optogenetics, oncotherapy and bioimaging. In this account, considering the primary benefits such as the absence of photobleaching, photoblinking, and autofluorescence of UCNPs not only facilitate the construction of accurate, sensitive and multifunctional nanoprobes, but also improve therapeutic and diagnostic results. We introduce, with the basic knowledge of upconversion, unique properties of UCNPs and the mechanisms involved in photon upconversion and discuss how UCNPs can be implemented in biological practices. In this focused review, we categorize the applications of UCNP-based various strategies into the following domains: neuromodulation, immunotherapy, drug delivery, photodynamic and photothermal therapy, bioimaging and biosensing. Herein, we also discuss the current emerging bioapplications with cutting edge nano-/biointerfacing of UCNPs. Finally, this review provides concluding remarks on future opportunities and challenges on clinical translation of UCNPs-based nanotechnology research.

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