scholarly journals Nanocharacterization of liposomes for the encapsulation of water soluble compounds from Cordyceps sinensis CS1197 by a supercritical gas anti-solvent technique

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34634-34649 ◽  
Author(s):  
G. M. Shashidhar ◽  
B. Manohar
Keyword(s):  
Sustained Release ◽  
Tween 80 ◽  
Water Soluble ◽  
Cordyceps Sinensis

Nano-liposomes were designed for the sustained release of water soluble compounds from C. sinensis CS1197 using a supercritical gas anti-solvent (SC-GAS) method at various pressures, temperatures and Tween 80 concentrations.

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

Compritol®888 ATO a Lipid Excipient for Sustained Release of Highly Water Soluble Active: Formulation, Scale-up and IVIVC Study

2013 ◽  
Vol 10 (5) ◽  
pp. 548-556 ◽  
Author(s):  
Shilpa Patere ◽  
Neha Desai ◽  
Ankitkumar Jain ◽  
Prashant Kadam ◽  
Urmila Thatte ◽  
...  
Keyword(s):  
Sustained Release ◽  
Scale Up ◽  
Water Soluble ◽  
Active Formulation

Development and Optimization of Sustained Release Moxifloxacin Hydrochloride Loaded Nanoemulsion for Ophthalmic Drug Delivery: A 32 Factorial Design Approach

2020 ◽  
Vol 12 ◽  
Author(s):  
Sagar R. Pardeshi ◽  
Harshal A. Mistari ◽  
Rakhi S. Jain ◽  
Pankaj R. Pardeshi ◽  
Rahul L. Rajput ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Factorial Design ◽  
Water Solubility ◽  
Tween 80 ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Bacterial Conjunctivitis ◽  
Promising Alternative

Background: Moxifloxacin is a BCS class I drug used in the treatment of bacterial conjunctivitis and keratitis. Despite its high water solubility, it possesses limited bioavailability due to anatomical and physiological constraints associated with the eyes which required multiple administrations to achieve a therapeutic effect. Objective: In order to prolong drug release and to improve antibacterial efficacy for the treatment of bacterial keratitis and conjunctivitis, moxifloxacin loaded nanoemulsion was developed. Methods: The concentration of oil (oleic acid), surfactant (tween 80), and cosurfactant (propylene glycol) were optimized by employing a 3-level 2-factorial design of experiment for the development of nanoemulsion. The developed nanoemulsion was characterized by particle size distribution, viscosity, refractive index, pH, drug content and release, transmission electron microscopy (TEM), and antibacterial study. The compatibility of the drug with the excipients was accessed by Fourier transform infrared spectroscopy (FTIR). Result: The average globule size was found to be 198.20 nm. The TEM study reveals the globules were nearly spherical and are well distributed. In vitro drug release profile for nanoemulsion shown sustained drug release (60.12% at the end of 6 h) compared to drug solution, where complete drug released within 2 h. The antibacterial effectiveness of the drug-loaded nanoemulsion was improved against S. aureus compared with the marketed formulation. Conclusion: The formulated sustained release nanoemulsion could be a promising alternative to eye drop with improved patient compliance by minimizing dosing frequency with improved antibacterial activity.

Polymer‐surfactant nanoparticles for sustained release of water‐soluble drugs

2007 ◽  
Vol 96 (12) ◽  
pp. 3379-3389 ◽  
Author(s):  
Mahesh D. Chavanpatil ◽  
Ayman Khdair ◽  
Yogesh Patil ◽  
Hitesh Handa ◽  
Guangzhao Mao ◽  
...  
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drugs ◽  
Polymer Surfactant

Sustained release of a model water-soluble compound via dry powder aerosolizable acetalated dextran microparticles

2019 ◽  
Vol 24 (9) ◽  
pp. 1133-1143 ◽  
Author(s):  
Nishan K. Shah ◽  
Zimeng Wang ◽  
Sweta K. Gupta ◽  
Andrew Le Campion ◽  
Samantha A. Meenach
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Dry Powder ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Model Water

scholarly journals Novel polystyrene sulfonate–silica microspheres as a carrier of a water soluble inorganic salt (KCl) for its sustained release, via a dual-release mechanism

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 478-481 ◽  
Author(s):  
Cong Sui ◽  
Jon A. Preece ◽  
Zhibing Zhang
Keyword(s):  
Sustained Release ◽  
Potassium Chloride ◽  
Inorganic Salt ◽  
Water Soluble ◽  
Release Mechanism ◽  
Aqueous Environment ◽  
Polystyrene Sulfonate ◽  
Silica Microspheres ◽  
Dual Release

Polystyrene sulfonate and silica microspheres with potassium chloride encapsulated show a dual-release mechanism of K+ in an aqueous environment.

scholarly journals High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Teresa Nabais ◽  
Grégoire Leclair
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Corn Starch ◽  
Water Soluble ◽  
Hydroxyl Groups ◽  
Sustained Drug Release ◽  
Tramadol Hydrochloride ◽  
Carboxymethyl Starch ◽  
High Amylose ◽  
Sodium Carboxymethyl Starch

Substituted amylose (SA) polymers were produced from high-amylose corn starch by etherification of its hydroxyl groups with chloroacetate. Amorphous high-amylose sodium carboxymethyl starch (HASCA), the resulting SA polymer, was spray-dried to obtain an excipient (SD HASCA) with optimal binding and sustained-release (SR) properties. Tablets containing different percentages of SD HASCA and tramadol hydrochloride were produced by direct compression and evaluated for dissolution. Once-daily and twice-daily SD HASCA tablets containing two common dosages of tramadol hydrochloride (100 mg and 200 mg), a freely water-soluble drug, were successfully developed. These SR formulations presented high crushing forces, which facilitate further tablet processing and handling. When exposed to both a pH gradient simulating the pH variations through the gastrointestinal tract and a 40% ethanol medium, a very rigid gel formed progressively at the surface of the tablets providing controlled drug-release properties. These properties indicated that SD HASCA was a promising and robust excipient for oral, sustained drug-release, which may possibly minimize the likelihood of dose dumping and consequent adverse effects, even in the case of coadministration with alcohol.

Sustained release of water-soluble drug from directly compressed alginate tablets

2003 ◽  
Vol 20 (4-5) ◽  
pp. 403-407 ◽  
Author(s):  
Øyvind Holte ◽  
Edvar Onsøyen ◽  
Rolf Myrvold ◽  
Jan Karlsen
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drug
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