Polymer‐surfactant nanoparticles for sustained release of water‐soluble drugs

2007 ◽  
Vol 96 (12) ◽  
pp. 3379-3389 ◽  
Author(s):  
Mahesh D. Chavanpatil ◽  
Ayman Khdair ◽  
Yogesh Patil ◽  
Hitesh Handa ◽  
Guangzhao Mao ◽  
...  
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drugs ◽  
Polymer Surfactant

scholarly journals Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Zhu Zhang ◽  
Wenbing Li ◽  
Guanghua Wang ◽  
Yang-Lu Qu ◽  
Deng-Guang Yu
Keyword(s):  
Sustained Release ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Drug Sustained Release ◽  
Water Soluble Drugs ◽  
Effective Delivery ◽  
Polyethylene Glycol 1000 ◽  
Poorly Water Soluble

Different from traditional solid dispersion (SD) for improving the dissolution rates of poorly water-soluble drugs, the upgraded 4th SD was developed to furnish a drug sustained-release profile. In this work, two different kinds of 4th SDs were fabricated using two electrospinning processes. One is a ternary SD (nanofibers F2) that consisted of ethyl cellulose (EC), polyethylene glycol 1000 (PEG), and tamoxifen citrate (TAM) from a modified coaxial process, and the other is a binary SD (nanofibers F1) which is comprised of EC and TAM from a single-fluid blending process. Scanning electronic microscopic observations demonstrated that F2 (330±50 nm) showed a better quality than F1 (870±230 nm) in terms of size and size distribution although both of them had a smooth surface morphology and a cross section. X-ray diffraction patterns verified that both SDs were amorphous nanocomposites owing to the favorable secondary interactions among these components, as suggested from the results of FTIR. In vitro dissolution experiments indicated that F2 could furnish an improved drug sustained-release characteristics compared to F1, exhausting all the contained TAM and having weaker leveling-off late release. The molecular behaviors of drug sustained-release from the binary 4th SD were suggested. The protocols reported here paved an alternative way for developing novel functional nanomaterials for effective delivery of poorly water-soluble drugs.

scholarly journals Use of chitosan for sustained-release preparations of water-soluble drugs.

1982 ◽  
Vol 30 (11) ◽  
pp. 4213-4215 ◽  
Author(s):  
YOICHI SAWAYANAGI ◽  
NAOKI NAMBU ◽  
TSUNEJI NAGAI
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drugs

scholarly journals The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

Biomolecules ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1330 ◽  
Author(s):  
Haixia Xu ◽  
Xizi Xu ◽  
Siyu Li ◽  
Wen-Liang Song ◽  
Deng-Guang Yu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Extended Release ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
The Core ◽  
Water Soluble Drug ◽  
Time Period ◽  
Drug Sustained Release ◽  
Water Soluble Drugs ◽  
Model Drug

The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

scholarly journals The application prospects and development trends of orally disintegrating tablets to dogs

2017 ◽  
Vol 47 (4) ◽  
Author(s):  
Tingting Yi
Keyword(s):  
Life Cycle ◽  
Sustained Release ◽  
Water Soluble ◽  
Development Trends ◽  
Poorly Water Soluble Drugs ◽  
Orally Disintegrating Tablets ◽  
Sustained Release Tablets ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Application Prospects

ABSTRACT: Orally disintegrating tablets (ODTs) disintegrate rapidly in the mouth in seconds when placed at the tongue. The introduction of ODTs for dogs can address many needs, ranging from convenient dosing for dogs with dysphagia to extending life cycle of drugs. Now, different technologies are widely combined for developing ODTs. The combination makes ODTs have more properties, obtaining orally disintegrating sustained release tablets or orally disintegrating enteric tablets or enhancing the dissolution rate and bioavailability of poorly water-soluble drugs and so on. The aim of this article is to give a comprehensive prospect to the application of ODTs to dogs, including ideal properties of drugs, indications of ODTs, considerations in developing ODTs and development trends of ODTs for dogs.

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