scholarly journals Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 25021-25030 ◽  
Author(s):  
Xueming Niu ◽  
Zhenyu Wang ◽  
Long Zhang ◽  
Yunyun Quan ◽  
Kun Wei
Keyword(s):  
Experimental Study ◽  
Protective Effect ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Anti Inflammatory

The drug 5-HMF (5-hydroxymethylfurfural, C6H6O3) is extensively studied for its antioxidative and anti-inflammatory properties.

scholarly journals Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

Marine Drugs ◽  
2018 ◽  
Vol 16 (7) ◽  
pp. 239 ◽  
Author(s):  
Lei Wang ◽  
WonWoo Lee ◽  
Jae Oh ◽  
Yong Cui ◽  
BoMi Ryu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Signaling Pathways ◽  
Dermal Fibroblasts ◽  
Sulfated Polysaccharides ◽  
Dependent Manner ◽  
Human Dermal Fibroblasts ◽  
Skin Damage ◽  
Hizikia Fusiforme ◽  
Hdf Cells

Our previous study evaluated the antioxidant activities of sulfated polysaccharides from Celluclast-assisted extract of Hizikia fusiforme (HFPS) in vitro in Vero cells and in vivo in zebrafish. The results showed that HFPS possesses strong antioxidant activity and suggested the potential photo-protective activities of HFPS. Hence, in the present study, we investigated the protective effects of HFPS against ultraviolet (UV) B-induced skin damage in vitro in human dermal fibroblasts (HDF cells). The results indicate that HFPS significantly reduced intracellular reactive oxygen species (ROS) level and improved the viability of UVB-irradiated HDF cells in a dose-dependent manner. Furthermore, HFPS significantly inhibited intracellular collagenase and elastase activities, remarkably protected collagen synthesis, and reduced matrix metalloproteinases (MMPs) expression by regulating nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPKs) signaling pathways in UVB-irradiated HDF cells. These results suggest that HFPS possesses strong UV protective effect, and can be a potential ingredient in the pharmaceutical and cosmetic industries.

scholarly journals The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality

2017 ◽  
Vol 8 (9) ◽  
pp. 3250-3258 ◽  
Author(s):  
José M. Alvarez-Suarez ◽  
Francesca Giampieri ◽  
Massimiliano Gasparrini ◽  
Luca Mazzoni ◽  
Celestino Santos-Buelga ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Antioxidant Enzyme ◽  
Bioactive Compounds ◽  
Antioxidant Enzyme Activity ◽  
Dermal Fibroblasts ◽  
Natural Source ◽  
Human Dermal Fibroblasts ◽  
Malpighia Emarginata

Acerola fruits are shown as an important natural source of bioactive compounds with beneficial properties for health.

scholarly journals Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts

2018 ◽  
Vol 818 ◽  
pp. 206-210
Author(s):  
Paweł Mozolewski ◽  
Joanna Jakóbkiewicz-Banecka ◽  
Grzegorz Węgrzyn ◽  
Bogdan Banecki ◽  
Magdalena Gabig-Cimińska
Keyword(s):  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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