Cytoprotective and Anti-inflammatory Effects of 6-Shogaol on Human Dermal Fibroblasts

2017 ◽  
Vol 15 (3) ◽  
pp. 367-376 ◽  
Author(s):  
Na-Kyeong Lee ◽  
Jung-Eun Ku ◽  
Hyo Sun Han
Keyword(s):  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Anti Inflammatory

scholarly journals Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts

2018 ◽  
Vol 818 ◽  
pp. 206-210
Author(s):  
Paweł Mozolewski ◽  
Joanna Jakóbkiewicz-Banecka ◽  
Grzegorz Węgrzyn ◽  
Bogdan Banecki ◽  
Magdalena Gabig-Cimińska
Keyword(s):  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 25021-25030 ◽  
Author(s):  
Xueming Niu ◽  
Zhenyu Wang ◽  
Long Zhang ◽  
Yunyun Quan ◽  
Kun Wei
Keyword(s):  
Experimental Study ◽  
Protective Effect ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Anti Inflammatory

The drug 5-HMF (5-hydroxymethylfurfural, C6H6O3) is extensively studied for its antioxidative and anti-inflammatory properties.

scholarly journals Anti-Inflammatory Effect of ETAS®50 by Inhibiting Nuclear Factor-κB p65 Nuclear Import in Ultraviolet-B-Irradiated Normal Human Dermal Fibroblasts

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ken Shirato ◽  
Tomoko Koda ◽  
Jun Takanari ◽  
Takuya Sakurai ◽  
Junetsu Ogasawara ◽  
...  
Keyword(s):  
Uv Irradiation ◽  
Nuclear Import ◽  
Dermal Fibroblasts ◽  
Nuclear Factor ◽  
Human Dermal Fibroblasts ◽  
Protein Levels ◽  
Proinflammatory Responses ◽  
Normal Human ◽  
Anti Inflammatory ◽  
Normal Human Dermal Fibroblasts

Ultraviolet (UV) irradiation induces proinflammatory responses in skin cells, including dermal fibroblasts, accelerating premature skin aging (photoaging). ETAS 50, a standardized extract from theAsparagus officinalisstem, is a novel and unique functional food that suppresses proinflammatory responses of hydrogen peroxide-stimulated skin fibroblasts and interleukin- (IL-) 1β-stimulated hepatocytes. To elucidate its antiphotoaging potencies, we examined whether ETAS 50 treatment after UV-B irradiation attenuates proinflammatory responses of normal human dermal fibroblasts (NHDFs). UV-B-irradiated NHDFs showed reduced levels of the cytosolic inhibitor of nuclear factor-κBα(IκBα) protein and increased levels of nuclear p65 protein. The nuclear factor-κB nuclear translocation inhibitor JSH-23 abolished UV-B irradiation-induced IL-1βmRNA expression, indicating that p65 regulates transcriptional induction. ETAS 50 also markedly suppressed UV-B irradiation-induced increases in IL-1βmRNA levels. Immunofluorescence analysis revealed that ETAS 50 retained p65 in the cytosol after UV-B irradiation. Western blotting also showed that ETAS 50 suppressed the UV-B irradiation-induced increases in nuclear p65 protein. Moreover, ETAS 50 clearly suppressed UV-B irradiation-induced distribution of importin-αprotein levels in the nucleus without recovering cytosolic IκBαprotein levels. These results suggest that ETAS 50 exerts anti-inflammatory effects on UV-B-irradiated NHDFs by suppressing the nuclear import machinery of p65. Therefore, ETAS 50 may prevent photoaging by suppressing UV irradiation-induced proinflammatory responses of dermal fibroblasts.

scholarly journals Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts

Processes ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 1040
Author(s):  
Jeong-Yong Park ◽  
Yun-Jeong Ji ◽  
Kyung Hye Seo ◽  
Ji Yeon Lee ◽  
Geum-Soog Kim ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Human Dermal Fibroblasts ◽  
Uvb Radiation ◽  
External Stimulation ◽  
Heat Treated ◽  
Licorice Extract ◽  
Anti Inflammatory

External stimulation of the skin by ultraviolet B (UVB) radiation induces oxidative stress or inflammation, causing skin aging and skin cancer. Glycyrrhiza uralensis (licorice) has been used as a medicinal plant for its antioxidant, anti-inflammatory, antiviral, antimicrobial, anticarcinogenic, and hepatoprotective properties. The present study analyzed the effects of thermal processing on the bioactivities of licorice. Heat-treated licorice (HL) extracts had better antioxidant and anti-inflammatory activities than nontreated licorice (NL) extract. HL extracts also had higher total phenol contents than NL extract. In particular, contents of isoliquiritigenin, an antioxidant and anti-inflammatory substance of licorice, increased in proportion to the skin-protection effects of HL extracts. Heat treatment increased the contents of phenolic compounds such as isoliquiritigenin in licorice extract, which improved the UV photoprotective effect of licorice in human dermal fibroblasts.

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