scholarly journals Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽  
2018 ◽  
Vol 8 (29) ◽  
pp. 16103-16113 ◽  
Author(s):  
Yiting Xu ◽  
Jie Cao ◽  
Qi Li ◽  
Jilu Li ◽  
Kaiwei He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Assembly Behavior

Polymeric micelles encapsulating and releasing hydrophobic guest molecules.

scholarly journals Correction: Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽  
2018 ◽  
Vol 8 (32) ◽  
pp. 17878-17878
Author(s):  
Yiting Xu ◽  
Jie Cao ◽  
Qi Li ◽  
Jilu Li ◽  
Kaiwei He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Assembly Behavior

Correction for ‘Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties’ by Yiting Xu et al., RSC Adv., 2018, 8, 16103–16113.

scholarly journals pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

2020 ◽  
Vol 16 ◽  
pp. 2017-2025
Author(s):  
Goutam Ghosh ◽  
Gustavo Fernández
Keyword(s):  
Self Assembly ◽  
Ph Value ◽  
Secondary Structures ◽  
Random Coil ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Force Microscopy ◽  
Assembly Behavior ◽  
Novel Drug

Peptide-based biopolymers represent highly promising biocompatible materials with multiple applications, such as tailored drug delivery, tissue engineering and regeneration, and as stimuli-responsive materials. Herein, we report the pH- and concentration-dependent self-assembly and conformational transformation of the newly synthesized octapeptide PEP-1. At pH 7.4, PEP-1 forms β-sheet-rich secondary structures into fractal-like morphologies, as verified by circular dichroism (CD), Fourier-transform infrared (FTIR) spectroscopy, thioflavin T (ThT) fluorescence spectroscopy assay, and atomic force microscopy (AFM). Upon changing the pH value (using pH 5.5 and 13.0), PEP-1 forms different types of secondary structures and resulting morphologies due to electrostatic repulsion between charged amino acids. PEP-1 can also form helical or random-coil secondary structures at a relatively low concentration. The obtained pH-sensitive self-assembly behavior of the target octapeptide is expected to contribute to the development of novel drug nanocarrier assemblies.

Macromolecular engineering and stimulus response in the design of advanced drug delivery systems

MRS Bulletin ◽  
2010 ◽  
Vol 35 (9) ◽  
pp. 665-672 ◽  
Author(s):  
Christine Jérôme
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Colloidal Particles ◽  
Polymeric Micelles ◽  
Complex Structure ◽  
Delivery Systems ◽  
Target Cells ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Research Activity

Extensive research activity is currently devoted to controlled drug delivery systems, mainly as nano-sized particles. Although biocompatible and (bio)degradable polymers play a key role in this field, their shaping into colloidal particles (e.g., polymeric micelles and nanoparticles) usually requires the proper design of amphiphilic copolymers as effective stabilizers. Strategies for synthesizing these copolymers that preserve the intrinsic properties of the constitutive polymers are discussed in this article. Synthesis of amphiphilic copolymers with a more complex structure and endowed with functionality is also considered, with the purpose of enhancing the performance of the nanocarriers. The focus is increasingly on nanocarriers of the third generation, which resist coalescence and elimination by the immune system, and which are readily incorporated into chosen target cells. The more recent quest is for smart nanocarriers that exhibit the additional capacity of being stimuli-responsive.

Study on polymeric micelles of poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer and its mixtures with poly(γ-benzyl l-glutamate) homopolymer in ethanol

2009 ◽  
Vol 63 (6) ◽  
Author(s):  
Guo-Quan Zhu
Keyword(s):  
Critical Micelle Concentration ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Mixed System ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Assembly Behavior ◽  
Ester Exchange Reaction ◽  
Poly Ethylene

AbstractPoly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) (PBLG-graft-PEG) copolymer was synthesized by the ester exchange reaction of the PBLG homopolymer with PEG. NMR spectroscopy was used to confirm the composition of the PBLG-graft-PEG copolymer. FTIR spectroscopy was used to characterize the chain conformation of polypeptide segments in the PBLG-graft-PEG copolymer in solid state. The self-assembly behavior of PBLG-graft-PEG and its mixtures with PBLG in ethanol were investigated by transmission electron microscopy (TEM) and viscometry. Experimental results showed that the PBLG-graft-PEG copolymer can self-assemble to form polymeric micelles with a core-shell structure of a thin shuttle-like shape. The introduction of the PBLG homopolymer into the mixed system not only decreases the critical micelle concentration (CMC) but also changes the morphology of the micelles from their shuttle-like shape to cylindrical shape. The effects of test temperature on the critical micelle concentration of PBLG-graft-PEG were also studied.

Self-Assembly Behavior of a Stimuli-Responsive Water-Soluble [60]Fullerene-Containing Polymer

Langmuir ◽  
2004 ◽  
Vol 20 (20) ◽  
pp. 8569-8575 ◽  
Author(s):  
S. Dai ◽  
P. Ravi ◽  
C. H. Tan ◽  
K. C. Tam
Keyword(s):  
Self Assembly ◽  
Water Soluble ◽  
Stimuli Responsive ◽  
Assembly Behavior

Dual Stimuli-Responsive Nucleobase-Functionalized Polymeric Systems as Efficient Tools for Manipulating Micellar Self-Assembly Behavior

2018 ◽  
Vol 51 (3) ◽  
pp. 1189-1197 ◽  
Author(s):  
Belete Tewabe Gebeyehu ◽  
Shan-You Huang ◽  
Ai-Wei Lee ◽  
Jem-Kun Chen ◽  
Juin-Yih Lai ◽  
...  
Keyword(s):  
Self Assembly ◽  
Stimuli Responsive ◽  
Polymeric Systems ◽  
Assembly Behavior
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