Dual Stimuli-Responsive Nucleobase-Functionalized Polymeric Systems as Efficient Tools for Manipulating Micellar Self-Assembly Behavior

2018 ◽  
Vol 51 (3) ◽  
pp. 1189-1197 ◽  
Author(s):  
Belete Tewabe Gebeyehu ◽  
Shan-You Huang ◽  
Ai-Wei Lee ◽  
Jem-Kun Chen ◽  
Juin-Yih Lai ◽  
...  
Keyword(s):  
Self Assembly ◽  
Stimuli Responsive ◽  
Polymeric Systems ◽  
Assembly Behavior

scholarly journals pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

2020 ◽  
Vol 16 ◽  
pp. 2017-2025
Author(s):  
Goutam Ghosh ◽  
Gustavo Fernández
Keyword(s):  
Self Assembly ◽  
Ph Value ◽  
Secondary Structures ◽  
Random Coil ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Force Microscopy ◽  
Assembly Behavior ◽  
Novel Drug

Peptide-based biopolymers represent highly promising biocompatible materials with multiple applications, such as tailored drug delivery, tissue engineering and regeneration, and as stimuli-responsive materials. Herein, we report the pH- and concentration-dependent self-assembly and conformational transformation of the newly synthesized octapeptide PEP-1. At pH 7.4, PEP-1 forms β-sheet-rich secondary structures into fractal-like morphologies, as verified by circular dichroism (CD), Fourier-transform infrared (FTIR) spectroscopy, thioflavin T (ThT) fluorescence spectroscopy assay, and atomic force microscopy (AFM). Upon changing the pH value (using pH 5.5 and 13.0), PEP-1 forms different types of secondary structures and resulting morphologies due to electrostatic repulsion between charged amino acids. PEP-1 can also form helical or random-coil secondary structures at a relatively low concentration. The obtained pH-sensitive self-assembly behavior of the target octapeptide is expected to contribute to the development of novel drug nanocarrier assemblies.

scholarly journals Correction: Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽  
2018 ◽  
Vol 8 (32) ◽  
pp. 17878-17878
Author(s):  
Yiting Xu ◽  
Jie Cao ◽  
Qi Li ◽  
Jilu Li ◽  
Kaiwei He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Assembly Behavior

Correction for ‘Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties’ by Yiting Xu et al., RSC Adv., 2018, 8, 16103–16113.

Self-Assembly Behavior of a Stimuli-Responsive Water-Soluble [60]Fullerene-Containing Polymer

Langmuir ◽  
2004 ◽  
Vol 20 (20) ◽  
pp. 8569-8575 ◽  
Author(s):  
S. Dai ◽  
P. Ravi ◽  
C. H. Tan ◽  
K. C. Tam
Keyword(s):  
Self Assembly ◽  
Water Soluble ◽  
Stimuli Responsive ◽  
Assembly Behavior

scholarly journals Dual Stimuli‐Responsive Self‐Assembly Behavior of a Tailor‐Made ABC‐Type Amphiphilic Tri‐Block Copolymer

2020 ◽  
Vol 58 (6) ◽  
pp. 843-851 ◽  
Author(s):  
Sanjay Pal ◽  
Michael Kather ◽  
Sovan Lal Banerjee ◽  
Pabitra Saha ◽  
Andrij Pich ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Assembly Behavior

Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

2011 ◽  
Vol 1301 ◽  
Author(s):  
Min Dai ◽  
Jennifer S. Haghpanah ◽  
Carlo Yuvienco ◽  
Jin Kim Montclare
Keyword(s):  
Self Assembly ◽  
Matrix Protein ◽  
Coiled Coil ◽  
Supramolecular Assembly ◽  
Stimuli Responsive ◽  
Block Polymers ◽  
Self Assembling ◽  
Assembly Behavior ◽  
Protein Block

ABSTRACTWe describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

scholarly journals Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽  
2018 ◽  
Vol 8 (29) ◽  
pp. 16103-16113 ◽  
Author(s):  
Yiting Xu ◽  
Jie Cao ◽  
Qi Li ◽  
Jilu Li ◽  
Kaiwei He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Assembly Behavior

Polymeric micelles encapsulating and releasing hydrophobic guest molecules.

scholarly journals Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer

2019 ◽  
Author(s):  
Colin Swenson ◽  
Arventh Velusamy ◽  
Hector Argueta-Gonzalez ◽  
Jennifer Heemstra
Keyword(s):  
Amino Acid ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Sequence Recognition ◽  
Potential Applications ◽  
Assembly Behavior ◽  
Aqueous Conditions

<div> <div> <div> <p>Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex structures and perform wide-ranging activities. Although Nature has evolved machinery to read the nucleic acid code and translate it into amino acid code, the extant biopolymers are restricted to encoding amino acid or nucleotide sequences separately, limiting their potential applications in medicine and biotechnology. Here we describe the design, synthesis, and stimuli-responsive assembly behavior of a bilingual biopolymer that integrates both amino acid and nucleobase sequences into a single peptide nucleic acid (PNA) scaffold to enable tunable storage and retrieval of tertiary structural behavior and programmable molecular recognition capabilities. Incorporation of a defined sequence of amino acid side-chains along the PNA backbone yields amphiphiles having a “protein code” that directs self-assembly into micellar architectures in aqueous conditions. However, these amphiphiles also carry a “nucleotide code” such that subsequent introduction of a complementary RNA strand induces a sequence-specific disruption of assemblies through hybridization. Together, these properties establish bilingual PNA as a powerful biopolymer that combines two information systems to harness structural responsiveness and sequence recognition. The PNA scaffold and our synthetic system are highly generalizable, enabling fabrication of a wide array of user-defined peptide and nucleotide sequence combinations for diverse future biomedical and nanotechnology applications. </p> </div> </div> </div>

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