Preparation and self-assembly behavior of thermosensitive polymeric micelles comprising poly(styrene-b-N,N-diethylacrylamide)

2008 ◽  
Vol 110 (2) ◽  
pp. 900-907 ◽  
Author(s):  
Fengling Bian ◽  
Miao Xiang ◽  
Wei Yu ◽  
Mingzhu Liu
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
Assembly Behavior

Study on polymeric micelles of poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer and its mixtures with poly(γ-benzyl l-glutamate) homopolymer in ethanol

2009 ◽  
Vol 63 (6) ◽  
Author(s):  
Guo-Quan Zhu
Keyword(s):  
Critical Micelle Concentration ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Mixed System ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Assembly Behavior ◽  
Ester Exchange Reaction ◽  
Poly Ethylene

AbstractPoly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) (PBLG-graft-PEG) copolymer was synthesized by the ester exchange reaction of the PBLG homopolymer with PEG. NMR spectroscopy was used to confirm the composition of the PBLG-graft-PEG copolymer. FTIR spectroscopy was used to characterize the chain conformation of polypeptide segments in the PBLG-graft-PEG copolymer in solid state. The self-assembly behavior of PBLG-graft-PEG and its mixtures with PBLG in ethanol were investigated by transmission electron microscopy (TEM) and viscometry. Experimental results showed that the PBLG-graft-PEG copolymer can self-assemble to form polymeric micelles with a core-shell structure of a thin shuttle-like shape. The introduction of the PBLG homopolymer into the mixed system not only decreases the critical micelle concentration (CMC) but also changes the morphology of the micelles from their shuttle-like shape to cylindrical shape. The effects of test temperature on the critical micelle concentration of PBLG-graft-PEG were also studied.

scholarly journals Novel azobenzene-based amphiphilic copolymers: synthesis, self-assembly behavior and multiple-stimuli-responsive properties

RSC Advances ◽  
2018 ◽  
Vol 8 (29) ◽  
pp. 16103-16113 ◽  
Author(s):  
Yiting Xu ◽  
Jie Cao ◽  
Qi Li ◽  
Jilu Li ◽  
Kaiwei He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Assembly Behavior

Polymeric micelles encapsulating and releasing hydrophobic guest molecules.

Self-Assembly of Single Chain Janus Nanoparticles from Azobenzene-Containing Block Copolymers and Reversible Photoinduced Morphology Transition

2021 ◽  
Author(s):  
Wei Wen ◽  
Aihua Chen
Keyword(s):  
Block Copolymers ◽  
Experimental Research ◽  
Self Assembly ◽  
The Self ◽  
Single Chain ◽  
Morphology Transition ◽  
Janus Nanoparticles ◽  
Assembly Behavior

Self-assembly of amphiphilic single chain Janus nanoparticles (SCJNPs) is a novel and promising approach to fabricate assemblies with diversified morphologies. However, the experimental research of the self-assembly behavior of SCJNPs...

scholarly journals Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Caio H. N. Barros ◽  
Dishon W. Hiebner ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Laura Quinn ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Glycolic Acid ◽  
Extracellular Polymeric Substances ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Enhanced Resistance ◽  
Antimicrobial Nanoparticles ◽  
Good Penetration ◽  
Antibiofilm Agents

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

scholarly journals The macroscopic shape of assemblies formed from microparticles based on host–guest interaction dependent on the guest content

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takahiro Itami ◽  
Akihito Hashidzume ◽  
Yuri Kamon ◽  
Hiroyasu Yamaguchi ◽  
Akira Harada
Keyword(s):  
Molecular Recognition ◽  
Smart Materials ◽  
Self Assembly ◽  
Early Stage ◽  
Contact Point ◽  
Sodium Acrylate ◽  
Contact Points ◽  
Assembly Behavior ◽  
Small Clusters ◽  
Macroscopic Shape

AbstractBiological macroscopic assemblies have inspired researchers to utilize molecular recognition to develop smart materials in these decades. Recently, macroscopic self-assemblies based on molecular recognition have been realized using millimeter-scale hydrogel pieces possessing molecular recognition moieties. During the study on macroscopic self-assembly based on molecular recognition, we noticed that the shape of assemblies might be dependent on the host–guest pair. In this study, we were thus motivated to study the macroscopic shape of assemblies formed through host–guest interaction. We modified crosslinked poly(sodium acrylate) microparticles, i.e., superabsorbent polymer (SAP) microparticles, with β-cyclodextrin (βCD) and adamantyl (Ad) residues (βCD(x)-SAP and Ad(y)-SAP microparticles, respectively, where x and y denote the mol% contents of βCD and Ad residues). Then, we studied the self-assembly behavior of βCD(x)-SAP and Ad(y)-SAP microparticles through the complexation of βCD with Ad residues. There was a threshold of the βCD content in βCD(x)-SAP microparticles for assembly formation between x = 22.3 and 26.7. On the other hand, the shape of assemblies was dependent on the Ad content, y; More elongated assemblies were formed at a higher y. This may be because, at a higher y, small clusters formed in an early stage can stick together even upon collisions at a single contact point to form elongated aggregates, whereas, at a smaller y, small clusters stick together only upon collisions at multiple contact points to give rather circular assemblies. On the basis of these observations, the shape of assembly formed from microparticles can be controlled by varying y.

Recording the Self-Assembly Behavior of Nanomaterials Directed by Hydrogen Bonding

2021 ◽  
Author(s):  
Ganghuo Pan ◽  
Jie Leng ◽  
Liye Deng ◽  
Liwen Xing ◽  
Rui Feng
Keyword(s):  
Hydrogen Bonding ◽  
Self Assembly ◽  
The Self ◽  
Assembly Behavior

Synthesis of star-comb-shaped polymer with porphyrin-core and its self-assembly behavior study

2012 ◽  
Vol 126 (6) ◽  
pp. 2067-2076 ◽  
Author(s):  
Bao Zhang ◽  
Di Wang ◽  
Meng Li ◽  
Yapeng Li ◽  
Xuesi Chen
Keyword(s):  
Self Assembly ◽  
Behavior Study ◽  
Porphyrin Core ◽  
Assembly Behavior
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