Strategies from nature: polycaprolactone-based mimetic antimicrobial peptide block copolymers with low cytotoxicity and excellent antibacterial efficiency

2019 ◽  
Vol 10 (8) ◽  
pp. 945-953 ◽  
Author(s):  
Xinyu Zhou ◽  
Jing He ◽  
Chuncai Zhou
Keyword(s):  
Drug Resistance ◽  
Block Copolymers ◽  
Antimicrobial Peptide ◽  
Diblock Copolymers ◽  
Antibacterial Activities ◽  
Antibacterial Efficiency ◽  
Bactericidal Mechanism ◽  
Low Cytotoxicity

PCL16-b-Kn diblock copolymers exhibit excellent antibacterial activities and low cytotoxicity. Meanwhile, they act by the pore-forming bactericidal mechanism without inducement of drug resistance.

Mechanical and Structural Consequences of Associative Dynamic Cross-Linking in Acrylic Diblock Copolymers

2019 ◽  
Author(s):  
Jacob Ishibashi ◽  
Yan Fang ◽  
Julia Kalow
Keyword(s):  
Block Copolymers ◽  
Rheological Properties ◽  
Diblock Copolymers ◽  
Cross Linking ◽  
Statistical Copolymer

<p>Block copolymers are used to construct covalent adaptable networks that employ associative exchange chemistry (vitrimers). The resulting vitrimers display markedly different nanostructural, thermal and rheological properties relative to those of their statistical copolymer-derived counterparts. This study demonstrates that prepolymer sequence is a versatile strategy to modify the properties of vitrimers.</p>

Amphiphilic Diblock Copolymers of Poly(glycidol) with Biodegradable Polyester/Polycarbonate. Organocatalytic One-Pot ROP and Self-Assembling Property

2021 ◽  
Author(s):  
Tingyu He ◽  
Atsushi Narumi ◽  
Yanqiu Wang ◽  
Liang Xu ◽  
Shin-ichiro Sato ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Diblock Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Synthetic Method ◽  
Biodegradable Polyester ◽  
One Pot ◽  
Self Assembling ◽  
Amphiphilic Diblock Copolymers

A synthetic method for a series of poly(glycidol) (PG)-based amphiphilic block copolymers is presented with an emphasis on the catalyst switch method from an organic superbase (t-Bu-P4) to another with...

Self-crosslinking assemblies with tunable nanostructures from photoresponsive polypeptoid-based block copolymers

2020 ◽  
Vol 11 (2) ◽  
pp. 337-343 ◽  
Author(s):  
Jirui Wei ◽  
Jing Sun ◽  
Xu Yang ◽  
Sifan Ji ◽  
Yuhan Wei ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Diblock Copolymers ◽  
New Family

A series of reversible crosslinking assemblies with tunable morphologies are obtained from a new family of photoresponsive polypeptoid-based diblock copolymers.

Synthesis, characterization and association behavior of linear-dendritic amphiphilic diblock copolymers based on poly(ethylene oxide) and a dendron derived from 2,2′-bis(hydroxymethyl)propionic acid

2015 ◽  
Vol 6 (12) ◽  
pp. 2274-2282 ◽  
Author(s):  
Weiwei Zhang ◽  
Weiwei Jiang ◽  
Delong Zhang ◽  
Guangyue Bai ◽  
Pengxiao Lou ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Propionic Acid ◽  
Diblock Copolymers ◽  
Association Behavior ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

Two new amphiphilic linear-dendritic block copolymers have been synthesized and characterized. And their association behaviors have also been studied.

Dilute Solutions of Block Copolymers. 1. Diblock Copolymers

1998 ◽  
Vol 31 (13) ◽  
pp. 4342-4349 ◽  
Author(s):  
O. F. Olaj ◽  
B. Neubauer ◽  
G. Zifferer
Keyword(s):  
Block Copolymers ◽  
Diblock Copolymers ◽  
Dilute Solutions

scholarly journals Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 185 ◽  
Author(s):  
Gowoon Kim ◽  
Ren-You Gan ◽  
Dan Zhang ◽  
Arakkaveettil Kabeer Farha ◽  
Olivier Habimana ◽  
...  
Keyword(s):  
Large Scale ◽  
Salvia Miltiorrhiza ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Cytotoxic Activities ◽  
Phenolic Contents ◽  
Medicinal Plant Extracts ◽  
Low Cytotoxicity

Novel alternative antibacterial compounds have been persistently explored from plants as natural sources to overcome antibiotic resistance leading to serious foodborne bacterial illnesses. In this study, the ethanolic extracts from 239 traditional Chinese medicinal plants (TCMP)’ materials were screened to discover promising candidates that have strong antibacterial properties against multidrug-resistant Staphylococcus (S.) aureus and low cytotoxicity. The results revealed that 74 extracts exhibited good antibacterial activities (diameter of inhibition zone (DIZ) ≥ 15 mm). Furthermore, 18 extracts (DIZ ≥ 20 mm) were determined their minimum inhibitory concentrations (MIC) and minimum bactericide concentrations (MBC), ranging from 0.1 to 12.5 mg/mL and 0.78 to 25 mg/mL, respectively. In addition, most of the 18 extracts showed relatively low cytotoxicity (a median lethal concentration (LC50) >100 µg/mL). The 18 extracts were further determined to estimate possible correlation of their phenolic contents with antibacterial activity, and the results did not show any significant correlation. In conclusion, this study selected out some promising antibacterial TCMP extracts with low cytotoxicity, including Rhus chinensis Mill., Ilex rotunda Thunb., Leontice kiangnanensis P.L.Chiu, Oroxylum indicum Vent., Isatis tinctorial L., Terminalia chebula Retz., Acacia catechu (L.f.) Willd., Spatholobus suberectus Dunn, Rabdosia rubescens (Hemsl.) H.Hara, Salvia miltiorrhiza Bunge, Fraxinus fallax Lingelsh, Coptis chinensis Franch., Agrimonia Pilosa Ledeb., and Phellodendron chinense C.K.Schneid.

scholarly journals A controlled synthesis method of alkyl methacrylate block copolymers via living anionic polymerization at ambient temperature

RSC Advances ◽  
2019 ◽  
Vol 9 (28) ◽  
pp. 16049-16056 ◽  
Author(s):  
Zheng Li ◽  
Jianding Chen ◽  
Guijin Zou ◽  
Tongyuan Zhang ◽  
Dafu Wei ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ambient Temperature ◽  
Anionic Polymerization ◽  
Diblock Copolymers ◽  
Synthesis Method ◽  
Controlled Synthesis ◽  
Living Anionic Polymerization ◽  
Alkyl Methacrylate ◽  
High Yields

A series of well-defined diblock copolymers containing PMMA, PEMA and PBMA blocks were synthesized with narrow MWDs and high yields via anionic polymerization, while t-BuOK was selected as initiator in THF at 0 °C. .

Phase Behavior of Mixed Langmuir Monolayers from Amphiphilic Block Copolymers and an Antimicrobial Peptide

Langmuir ◽  
2006 ◽  
Vol 22 (3) ◽  
pp. 1164-1172 ◽  
Author(s):  
Thomas Haefele ◽  
Katarzyna Kita-Tokarczyk ◽  
Wolfgang Meier
Keyword(s):  
Block Copolymers ◽  
Antimicrobial Peptide ◽  
Phase Behavior ◽  
Langmuir Monolayers ◽  
Amphiphilic Block Copolymers

scholarly journals Two-dimensional chromatography of complex polymers. 3. Full analysis of polystyrene-poly(methyl methacrylate) diblock copolymers

e-Polymers ◽  
2002 ◽  
Vol 2 (1) ◽  
Author(s):  
Harald Pasch ◽  
Kibret Mequanint ◽  
Adrian Jörg
Keyword(s):  
Block Copolymers ◽  
Methyl Methacrylate ◽  
Diblock Copolymers ◽  
Size Exclusion ◽  
Molecular Heterogeneity ◽  
Two Dimensional ◽  
Poly Methyl Methacrylate ◽  
Mass Distributions ◽  
Exclusion Chromatography ◽  
Complex Polymers

AbstractPoly(styrene-block-methyl methacrylate)s were fully analyzed by liquid chromatography at the critical point of adsorption (LC-CC) and two-dimensional chromatography. Operating at chromatographic conditions corresponding to the critical points of the homopolymers polystyrene and poly(methyl methacrylate), the block lengths distributions for the different blocks of the block copolymers were determined quantitatively. Information on the amounts and molar mass distributions of homopolymers and coupling products that were identified in the samples as by-products was obtained by on-line coupled 2D chromatography. It was shown that a complete picture of the molecular heterogeneity of block copolymers can be obtained only when information from different chromatographic experiments is combined. Size exclusion chromatography alone is inappropriate for evaluating the molecular heterogeneity of such samples.

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