ChemInform Abstract: 6-Methyl-5-azacytidine (IV) - Synthesis, Conformational Properties, and Biological Activity. A Comparison of Molecular Conformation with 5- Azacytidine.

ChemInform ◽  
2010 ◽  
Vol 28 (27) ◽  
pp. no-no
Author(s):  
N. B. HANNA ◽  
J. ZAJICEK ◽  
A. PISKALA
Keyword(s):  
Biological Activity ◽  
Molecular Conformation ◽  
Conformational Properties

scholarly journals Dynamic behaviour of oxidized glutathione in solution investigated by nuclear magnetic resonance

1993 ◽  
Vol 71 (4) ◽  
pp. 506-511
Author(s):  
Claudio Rossi ◽  
Alessandro Donati ◽  
Sergio Ulgiati ◽  
Maria Rosaria Sansoni
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Biological Activity ◽  
Magnetic Resonance ◽  
Spin Label ◽  
Molecular Motion ◽  
Dynamic Behaviour ◽  
Oxidized Glutathione ◽  
Biological Functions ◽  
Conformational Properties ◽  
Structure In Solution

In view of the important biological functions of oxidized glutathione (GSSG), we investigated the correlation between dynamic and conformational properties and biological activity. Anisotropic molecular motion characterizes different GSSG molecular districts. This information, obtained by NMR carbon relaxation investigations, suggests that the peptide does not independently assume any stable structure in solution. Analysis of the effects of the addition of a stable spin label to the solution confirmed the absence of conformation of GSSG in D2O. Moreover, the paramagnetic effects observed on proton and carbon nuclei of oxidized glutathione suggest that the dipolar term is the main source of paramagnetic relaxation.

ChemInform Abstract: Synthesis, Molecular Conformation and Biological Activity of 6-Amino-5-azacytidine.

ChemInform ◽  
1990 ◽  
Vol 21 (4) ◽  
Author(s):  
A. PISKALA ◽  
N. B. HANNA ◽  
J. ZAJICEK ◽  
A. CIHAK
Keyword(s):  
Biological Activity ◽  
Molecular Conformation

Influence of fluorine substitution on the molecular conformation of 3′-deoxy-3′-fluoro-5-methyluridine

2020 ◽  
Vol 76 (4) ◽  
pp. 346-352
Author(s):  
Manisha N. Aher ◽  
Namrata D. Erande ◽  
Vaijayanti A. Kumar ◽  
Moneesha Fernandes ◽  
Rajesh G. Gonnade
Keyword(s):  
Molecular Conformation ◽  
Asymmetric Unit ◽  
Screw Axis ◽  
Orthorhombic Space Group ◽  
Fluorine Substitution ◽  
X Ray ◽  
X Ray Crystallography ◽  
Conformational Properties ◽  
Independent Molecules ◽  
Phase Angles

Fluorine substitutions on the furanose ring of nucleosides are known to strongly influence the conformational properties of oligonucleotides. In order to assess the effect of fluorine on the conformation of 3′-deoxy-3′-fluoro-5-methyluridine (RTF), C10H13FN2O5, we studied its stereochemistry in the crystalline state using X-ray crystallography. The compound crystallizes in the chiral orthorhombic space group P212121 and contains two symmetry-independent molecules (A and B) in the asymmetric unit. The furanose ring in molecules A and B adopts conformations between envelope (2E, 2′-endo, P = 162°) and twisted (2T3, 2′-endo and 3′exo, P = 180°), with pseudorotation phase angles (P) of 164.3 and 170.2°, respectively. The maximum puckering amplitudes, νmax, for molecules A and B are 38.8 and 36.1°, respectively. In contrast, for 5-methyluridine (RTOH), the value of P is 21.2°, which is between the 3E (3′-endo, P = 18.0°) and 3T4 (3′-endo and 4′-exo, P = 36°) conformations. The value of νmax for RTOH is 41.29°. Molecules A and B of RTF generate respective helical assemblies across the crystallographic 21-screw axis through classical N—H...O aand O—H...O hydrogen bonds supplemented by C—H...O contacts. Adjacent parallel helices of both molecules are linked to each other via O—H...O and O...π interactions.

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

2019 ◽  
Vol 17 (3) ◽  
pp. 664-674 ◽  
Author(s):  
Catherine Au ◽  
Christina Gonzalez ◽  
Yun Cheuk Leung ◽  
Flora Mansour ◽  
Johny Trinh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Molecular Conformation ◽  
Synthetic Efficiency

Fluorination alters a cyclic peptide's synthetic efficiency, its molecular conformation, and its biological activity.

Conformational properties of the analgesic peptide dermorphin and their relationships to biological activity

1988 ◽  
Vol 164 (1-2) ◽  
pp. 153-164 ◽  
Author(s):  
Graziella Ranghino ◽  
Camillo Tosi ◽  
Luisa Barino ◽  
Raimondo Scordamaglia ◽  
Roberto Fusco
Keyword(s):  
Biological Activity ◽  
Conformational Properties ◽  
Analgesic Peptide

Folding propensity and biological activity of peptides: New insights from conformational properties of a novel peptide derived fromVitreoscilla haemoglobin

Biopolymers ◽  
2007 ◽  
Vol 87 (1) ◽  
pp. 85-92 ◽  
Author(s):  
A. Bozzi ◽  
C. Coccia ◽  
A. Di Giulio ◽  
A. C. Rinaldi ◽  
A. Amadei ◽  
...  
Keyword(s):  
Biological Activity ◽  
Conformational Properties
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