The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

2019 ◽  
Vol 17 (4) ◽  
pp. 807-812 ◽  
Author(s):  
Li-Hua Du ◽  
Zhen Dong ◽  
Rui-Jie Long ◽  
Ping-Feng Chen ◽  
Miao Xue ◽  
...  
Keyword(s):  
Michael Addition ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Lipozyme Tl Im ◽  
Flow Microreactor ◽  
Enzymatic Microreactors

A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K2CO3 in a continuous-flow microreactor

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59100-59103 ◽  
Author(s):  
Li-Hua Du ◽  
Bing-Zhuo Cheng ◽  
Wen-Jun Yang ◽  
Liang-Liang Xu ◽  
Xi-Ping Luo
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Vinyl Esters ◽  
Lipozyme Tl Im ◽  
Imidazole Derivatives ◽  
Flow Microreactor ◽  
Markovnikov Addition

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K2CO3 in a continuous-flow microreactor was described.

scholarly journals Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

RSC Advances ◽  
2018 ◽  
Vol 8 (23) ◽  
pp. 12614-12618 ◽  
Author(s):  
Li-Hua Du ◽  
Jia-Hong Shen ◽  
Zhen Dong ◽  
Na-Ni Zhou ◽  
Bing-Zhuo Cheng ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Nucleoside Analogues ◽  
Hydroxyl Group ◽  
Vinyl Esters ◽  
Regioselective Acylation ◽  
Primary Hydroxyl ◽  
Flow Microreactor

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.

scholarly journals A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors

RSC Advances ◽  
2020 ◽  
Vol 10 (22) ◽  
pp. 13252-13259
Author(s):  
Li-Hua Du ◽  
Ping-Feng Chen ◽  
Rui-Jie Long ◽  
Miao Xue ◽  
Xi-Ping Luo
Keyword(s):  
Continuous Flow ◽  
Environmentally Friendly ◽  
Thermomyces Lanuginosus ◽  
Coumarin Derivatives ◽  
Lipozyme Tl Im ◽  
Sustainable Innovation ◽  
Flow Microreactors ◽  
Tandem Synthesis

An effective and environmentally friendly two-step tandem protocol for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM in continuous-flow microreactors has been developed.

scholarly journals Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 432 ◽  
Author(s):  
Li-Hua Du ◽  
Rui-Jie Long ◽  
Miao Xue ◽  
Ping-Feng Chen ◽  
Meng-Jie Yang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Continuous Flow ◽  
Aromatic Amines ◽  
Reaction Medium ◽  
Thermomyces Lanuginosus ◽  
Amino Acid Esters ◽  
New Strategy ◽  
Flow Microreactors ◽  
Acid Esters

A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM from Thermomyces lanuginosus was first used to catalyze Michael addition reaction of aromatic amines. Compared with other methods, the salient features of this work include green reaction conditions (methanol as reaction medium), short residence time (30 min), readily available catalyst and a reaction process that is easy to control. This enzymatic synthesis of β-amino acid esters performed in continuous-flow microreactors is an innovation that provides a new strategy for the fast biotransformation of β-amino acid esters.

Transformation of 1-Butene over Synthetic Zeolites

1992 ◽  
Vol 57 (4) ◽  
pp. 869-881 ◽  
Author(s):  
Italo Ferino ◽  
Roberto Monaci ◽  
Vincenzo Solinas ◽  
Lucio Forni ◽  
Antonio Rivoldini ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Flow ◽  
Liquid Mixture ◽  
Isomerization Reaction ◽  
Reaction Conditions ◽  
Title Reaction ◽  
Y Zeolites ◽  
Temperature Range ◽  
Flow Microreactor ◽  
Synthetic Zeolites

The behaviour of several zeolites as catalysts for the title reaction has been investigated by means of a continuous flow microreactor. Runs performed at atmospheric pressure indicated that at 423 K the completely protonic forms of the zeolites catalyze just the isomerization reaction. In the case of Y zeolites, oligomerization occurs only over the partially decationated samples, in the temperature range between 373 and 423 K and W/F between 0.2 and 22 gcath/g1-but, to an extent which depends on the reaction conditions. Most of the catalysts were tested also under pressure (4.05 MPa) at 423 K. The protonic forms of Y and ZSM-5 zeolites seem promising catalysts in terms of both conversion and selectivity to oligomers. The 1-olefins account for 30% of the entire olefinic mixture. The octenes, which account for 70% of the liquid mixture, are mostly formed of dimethylhexenes. Trimers are also formed during the reaction and, in the very particular case of H[B]ZSM-5, tetramers are produced.

Enzymatic synthesis of a chiral chalcogran intermediate

2014 ◽  
Vol 68 (6) ◽  
Author(s):  
Vladimír Mastihuba ◽  
Pavel Čepec ◽  
Silvia Vlčková ◽  
Erika Farkašová ◽  
Mária Mastihubová ◽  
...  
Keyword(s):  
Vinyl Acetate ◽  
Bark Beetle ◽  
Enzymatic Synthesis ◽  
Kinetic Resolution ◽  
Thermomyces Lanuginosus ◽  
Methyl Tert Butyl Ether ◽  
Lipozyme Tl Im ◽  
Butyl Ether ◽  
Novozyme 435 ◽  
Reaction Media

AbstractTwo lipases, Novozyme 435 (lipase B from Candida Antarctica) and Lipozyme TL IM (Thermomyces lanuginosus) were used successfully for the kinetic resolution of racemic 1-(2-furyl)-3-pentanol, the key intermediate in synthesis of the bark beetle pheromone, chalcogran. The desired S-(+)-enantiomer was prepared in enantiomeric excesses higher than 98 % and with yields of 26.3 % and 32.5 %, respectively. Methyl tert-butyl ether and vinyl acetate were found to be the best reaction media and the acetyl donor to achieve fast and effective resolution.

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