scholarly journals A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors

RSC Advances ◽  
2020 ◽  
Vol 10 (22) ◽  
pp. 13252-13259
Author(s):  
Li-Hua Du ◽  
Ping-Feng Chen ◽  
Rui-Jie Long ◽  
Miao Xue ◽  
Xi-Ping Luo
Keyword(s):  
Continuous Flow ◽  
Environmentally Friendly ◽  
Thermomyces Lanuginosus ◽  
Coumarin Derivatives ◽  
Lipozyme Tl Im ◽  
Sustainable Innovation ◽  
Flow Microreactors ◽  
Tandem Synthesis

An effective and environmentally friendly two-step tandem protocol for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM in continuous-flow microreactors has been developed.

Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K2CO3 in a continuous-flow microreactor

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59100-59103 ◽  
Author(s):  
Li-Hua Du ◽  
Bing-Zhuo Cheng ◽  
Wen-Jun Yang ◽  
Liang-Liang Xu ◽  
Xi-Ping Luo
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Vinyl Esters ◽  
Lipozyme Tl Im ◽  
Imidazole Derivatives ◽  
Flow Microreactor ◽  
Markovnikov Addition

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K2CO3 in a continuous-flow microreactor was described.

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

2019 ◽  
Vol 17 (4) ◽  
pp. 807-812 ◽  
Author(s):  
Li-Hua Du ◽  
Zhen Dong ◽  
Rui-Jie Long ◽  
Ping-Feng Chen ◽  
Miao Xue ◽  
...  
Keyword(s):  
Michael Addition ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Lipozyme Tl Im ◽  
Flow Microreactor ◽  
Enzymatic Microreactors

A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

scholarly journals Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 432 ◽  
Author(s):  
Li-Hua Du ◽  
Rui-Jie Long ◽  
Miao Xue ◽  
Ping-Feng Chen ◽  
Meng-Jie Yang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Continuous Flow ◽  
Aromatic Amines ◽  
Reaction Medium ◽  
Thermomyces Lanuginosus ◽  
Amino Acid Esters ◽  
New Strategy ◽  
Flow Microreactors ◽  
Acid Esters

A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM from Thermomyces lanuginosus was first used to catalyze Michael addition reaction of aromatic amines. Compared with other methods, the salient features of this work include green reaction conditions (methanol as reaction medium), short residence time (30 min), readily available catalyst and a reaction process that is easy to control. This enzymatic synthesis of β-amino acid esters performed in continuous-flow microreactors is an innovation that provides a new strategy for the fast biotransformation of β-amino acid esters.

Enzymatic synthesis of a chiral chalcogran intermediate

2014 ◽  
Vol 68 (6) ◽  
Author(s):  
Vladimír Mastihuba ◽  
Pavel Čepec ◽  
Silvia Vlčková ◽  
Erika Farkašová ◽  
Mária Mastihubová ◽  
...  
Keyword(s):  
Vinyl Acetate ◽  
Bark Beetle ◽  
Enzymatic Synthesis ◽  
Kinetic Resolution ◽  
Thermomyces Lanuginosus ◽  
Methyl Tert Butyl Ether ◽  
Lipozyme Tl Im ◽  
Butyl Ether ◽  
Novozyme 435 ◽  
Reaction Media

AbstractTwo lipases, Novozyme 435 (lipase B from Candida Antarctica) and Lipozyme TL IM (Thermomyces lanuginosus) were used successfully for the kinetic resolution of racemic 1-(2-furyl)-3-pentanol, the key intermediate in synthesis of the bark beetle pheromone, chalcogran. The desired S-(+)-enantiomer was prepared in enantiomeric excesses higher than 98 % and with yields of 26.3 % and 32.5 %, respectively. Methyl tert-butyl ether and vinyl acetate were found to be the best reaction media and the acetyl donor to achieve fast and effective resolution.

scholarly journals Rational Design of High-Performance Continuous-Flow Microreactors Based on Gold Nanoclusters and Graphene for Catalysis

2018 ◽  
Vol 6 (11) ◽  
pp. 15425-15433 ◽  
Author(s):  
Yanbiao Liu ◽  
Xiang Liu ◽  
Shengnan Yang ◽  
Fang Li ◽  
Chensi Shen ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Performance ◽  
Rational Design ◽  
Gold Nanoclusters ◽  
Flow Microreactors

Rapid synthesis of polyimide precursors by solution polymerization using Continuous-flow microreactors

2020 ◽  
Vol 397 ◽  
pp. 125361 ◽  
Author(s):  
Wenhua Xu ◽  
Yuanhai Su ◽  
Minjing Shang ◽  
Xueming Lu ◽  
Qinghua Lu
Keyword(s):  
Continuous Flow ◽  
Solution Polymerization ◽  
Rapid Synthesis ◽  
Flow Microreactors

scholarly journals Synthesis of Dietetic Structured Lipids from Spent Coffee Grounds Crude Oil Catalyzed by Commercial Immobilized Lipases and Immobilized Rhizopus oryzae Lipase on Biochar and Hybrid Support

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1542
Author(s):  
Danyelle A. Mota ◽  
Jefferson C. B. Santos ◽  
Diana Faria ◽  
Álvaro S. Lima ◽  
Laiza C. Krause ◽  
...  
Keyword(s):  
Crude Oil ◽  
Rhizopus Oryzae ◽  
Structured Lipids ◽  
Thermomyces Lanuginosus ◽  
Spent Coffee Grounds ◽  
Lipozyme Tl Im ◽  
Rhizopus Oryzae Lipase ◽  
Lipozyme Rm Im ◽  
Coffee Grounds ◽  
Pharmaceutical Industries

The aim of this study was the valorization of coffee industry residues, namely spent coffee grounds (SCG) as a source of oil, and silverskin (CS) as a source of both oil and biomass, under the concept of the circular economy. Therefore, crude oil from SCG was used to produce low-calorie structured lipids (SL) for food and pharmaceutical industries, and CS to produce biochar by pyrolysis for biotechnological uses. SL were obtained by acidolysis with caprylic or capric acid, or interesterification with ethyl caprylate or ethyl caprate, in solvent-free media, catalyzed by immobilized sn-1,3 regioselective lipases. Silverskin biochar (BIO) was directly used as enzyme carrier or to produce hybrid organic-silica (HB) supports for enzyme immobilization. Rhizopus oryzae lipase (ROL) immobilized on Amberlite (AMB), silica (SIL), BIO or HB, and the commercial immobilized Thermomyces lanuginosus (Lipozyme TL IM) and Rhizomucor miehei (Lipozyme RM IM) lipases were tested. Lipozyme RM IM showed better results in SL production than Lipozyme TLIM or ROL on BIO, SIL or HB. About 90% triacylglycerol conversion was attained after 7 h acidolysis or interesterification. Lipozyme RM IM was more stable in interesterification (80% and 65% activity with ethyl caprylate or ethyl caprate) than in acidolysis (first-order decay) after 10 reuses.

Sign in / Sign up

Export Citation Format

Share Document