Michael addition of pyrimidine derivatives with acrylates catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow microreactor

RSC Advances ◽  
2014 ◽  
Vol 4 (15) ◽  
pp. 7770 ◽  
Author(s):  
Li-Hua Du ◽  
Hui-Min Ling ◽  
Xi-Ping Luo
Keyword(s):  
Michael Addition ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Pyrimidine Derivatives ◽  
Flow Microreactor

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

2019 ◽  
Vol 17 (4) ◽  
pp. 807-812 ◽  
Author(s):  
Li-Hua Du ◽  
Zhen Dong ◽  
Rui-Jie Long ◽  
Ping-Feng Chen ◽  
Miao Xue ◽  
...  
Keyword(s):  
Michael Addition ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Lipozyme Tl Im ◽  
Flow Microreactor ◽  
Enzymatic Microreactors

A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K2CO3 in a continuous-flow microreactor

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59100-59103 ◽  
Author(s):  
Li-Hua Du ◽  
Bing-Zhuo Cheng ◽  
Wen-Jun Yang ◽  
Liang-Liang Xu ◽  
Xi-Ping Luo
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Vinyl Esters ◽  
Lipozyme Tl Im ◽  
Imidazole Derivatives ◽  
Flow Microreactor ◽  
Markovnikov Addition

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K2CO3 in a continuous-flow microreactor was described.

scholarly journals Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

RSC Advances ◽  
2018 ◽  
Vol 8 (23) ◽  
pp. 12614-12618 ◽  
Author(s):  
Li-Hua Du ◽  
Jia-Hong Shen ◽  
Zhen Dong ◽  
Na-Ni Zhou ◽  
Bing-Zhuo Cheng ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Continuous Flow ◽  
Thermomyces Lanuginosus ◽  
Nucleoside Analogues ◽  
Hydroxyl Group ◽  
Vinyl Esters ◽  
Regioselective Acylation ◽  
Primary Hydroxyl ◽  
Flow Microreactor

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.

scholarly journals Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 432 ◽  
Author(s):  
Li-Hua Du ◽  
Rui-Jie Long ◽  
Miao Xue ◽  
Ping-Feng Chen ◽  
Meng-Jie Yang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Continuous Flow ◽  
Aromatic Amines ◽  
Reaction Medium ◽  
Thermomyces Lanuginosus ◽  
Amino Acid Esters ◽  
New Strategy ◽  
Flow Microreactors ◽  
Acid Esters

A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM from Thermomyces lanuginosus was first used to catalyze Michael addition reaction of aromatic amines. Compared with other methods, the salient features of this work include green reaction conditions (methanol as reaction medium), short residence time (30 min), readily available catalyst and a reaction process that is easy to control. This enzymatic synthesis of β-amino acid esters performed in continuous-flow microreactors is an innovation that provides a new strategy for the fast biotransformation of β-amino acid esters.

Transformation of 1-Butene over Synthetic Zeolites

1992 ◽  
Vol 57 (4) ◽  
pp. 869-881 ◽  
Author(s):  
Italo Ferino ◽  
Roberto Monaci ◽  
Vincenzo Solinas ◽  
Lucio Forni ◽  
Antonio Rivoldini ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Flow ◽  
Liquid Mixture ◽  
Isomerization Reaction ◽  
Reaction Conditions ◽  
Title Reaction ◽  
Y Zeolites ◽  
Temperature Range ◽  
Flow Microreactor ◽  
Synthetic Zeolites

The behaviour of several zeolites as catalysts for the title reaction has been investigated by means of a continuous flow microreactor. Runs performed at atmospheric pressure indicated that at 423 K the completely protonic forms of the zeolites catalyze just the isomerization reaction. In the case of Y zeolites, oligomerization occurs only over the partially decationated samples, in the temperature range between 373 and 423 K and W/F between 0.2 and 22 gcath/g1-but, to an extent which depends on the reaction conditions. Most of the catalysts were tested also under pressure (4.05 MPa) at 423 K. The protonic forms of Y and ZSM-5 zeolites seem promising catalysts in terms of both conversion and selectivity to oligomers. The 1-olefins account for 30% of the entire olefinic mixture. The octenes, which account for 70% of the liquid mixture, are mostly formed of dimethylhexenes. Trimers are also formed during the reaction and, in the very particular case of H[B]ZSM-5, tetramers are produced.

scholarly journals Dynamic characterization of nanoparticles production in a droplet-based continuous flow microreactor

2019 ◽  
Vol 144 ◽  
pp. 247-257 ◽  
Author(s):  
Haiyun Ma ◽  
Nan Jin ◽  
Peng Zhang ◽  
Yufei Zhou ◽  
Yuchao Zhao ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Dynamic Characterization ◽  
Flow Microreactor
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