Highly efficient synthesis of benzodioxins with a 2-site quaternary carbon structure by secondary amine-catalyzed dual Michael cascade reactions

2018 ◽  
Vol 16 (30) ◽  
pp. 5533-5538 ◽  
Author(s):  
Xuefeng He ◽  
Yongsu Li ◽  
Meng Wang ◽  
Hui-Xuan Chen ◽  
Bin Chen ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Quaternary Carbon ◽  
Carbon Structure ◽  
Highly Efficient ◽  
Salicylic Acids

Employing salicylic acids and substituted 3-butyn-2-ones as the substrates, a morpholine catalyzed tandem dual Michael addition afforded a benzodioxin skeleton.

A Highly Efficient Synthesis of Lamellarins K and L by the Michael Addition/Ring-Closure Reaction of Benzyldihydroisoquinoline Derivatives with Ethoxycarbonyl-β-nitrostyrenes

2004 ◽  
Vol 116 (7) ◽  
pp. 884-886 ◽  
Author(s):  
Poonsakdi Ploypradith ◽  
Chulabhorn Mahidol ◽  
Poolsak Sahakitpichan ◽  
Siriporn Wongbundit ◽  
Somsak Ruchirawat
Keyword(s):  
Michael Addition ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
The Michael Addition

Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

2014 ◽  
Vol 50 (17) ◽  
pp. 2196-2198 ◽  
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Chaoqun Ma ◽  
Huang Qiu ◽  
Shunying Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Mannich Reactions ◽  
Cyclic Acetals ◽  
Brönsted Acid

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a and its stereoselective Michael addition reaction

2015 ◽  
Vol 13 (7) ◽  
pp. 1992-1995 ◽  
Author(s):  
Jiazhu Li ◽  
Yang Liu ◽  
Xi-Sen Xu ◽  
Yan-Long Li ◽  
Shan-Guo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Michael Reaction ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
Highly Efficient ◽  
Ph Dependent

pH-Dependent regioselective condensation of methyl mesopyropheophorbide a with HCHO is studied and stereoselective Michael reaction of the 132-methylene product is also discussed.

Squaramide−catalysed asymmetric Michael addition/cyclization cascade reactions of 4-arylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones

2021 ◽  
Author(s):  
Xiqiang Hou ◽  
Jiang-Bo Wen ◽  
Li Yan ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Highly Efficient ◽  
Asymmetric Michael Addition

A highly efficient cinchona alkaloid‐derived squaramide catalysed asymmetric Michael/cyclization cascade reaction of 4‐ arylmethylidene‐2,3‐dioxopyrrolidines with 2‐isothiocyanato‐1‐indanones was successfully developed. This protocol provides an efficient and mild access to obtain indanone‐derived...

A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen–metal exchange of substituted MOM protected phenols followed by carboxylation.

2001 ◽  
Vol 79 (11) ◽  
pp. 1541-1545
Author(s):  
Stephen YW Lau ◽  
Brian A Keay
Keyword(s):  
Metal Exchange ◽  
Efficient Synthesis ◽  
Efficient Strategy ◽  
Highly Efficient ◽  
Ortho Metalation ◽  
Salicylic Acids

A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.Key words: salicylic acids, ortho-metalation, halogen–metal exchange, methoxymethyl group.

Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

2015 ◽  
Vol 127 (25) ◽  
pp. 7489-7493 ◽  
Author(s):  
Jin-Sheng Yu ◽  
Fu-Min Liao ◽  
Wei-Ming Gao ◽  
Kui Liao ◽  
Run-Lin Zuo ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Quaternary Carbon ◽  
Enol Ethers ◽  
Silyl Enol Ethers

A Highly Efficient Synthesis of Lamellarins K and L by the Michael Addition/Ring-Closure Reaction of Benzyldihydroisoquinoline Derivatives with Ethoxycarbonyl-β-nitrostyrenes

2004 ◽  
Vol 43 (7) ◽  
pp. 866-868 ◽  
Author(s):  
Poonsakdi Ploypradith ◽  
Chulabhorn Mahidol ◽  
Poolsak Sahakitpichan ◽  
Siriporn Wongbundit ◽  
Somsak Ruchirawat
Keyword(s):  
Michael Addition ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
The Michael Addition
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