A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen–metal exchange of substituted MOM protected phenols followed by carboxylation.

2001 ◽  
Vol 79 (11) ◽  
pp. 1541-1545
Author(s):  
Stephen YW Lau ◽  
Brian A Keay

A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.Key words: salicylic acids, ortho-metalation, halogen–metal exchange, methoxymethyl group.

Synlett ◽  
2015 ◽  
Vol 26 (08) ◽  
pp. 1096-1100 ◽  
Author(s):  
Sarva Jayaprakash ◽  
Mekala Ramamohan ◽  
Regati Sridhar ◽  
Kamaraju Raghavendrarao ◽  
Naidu Paradesi ◽  
...  

A simple and highly efficient strategy is developed for the synthesis of indolo- and pyrrolo[1,2-a]quinoxalines from the corresponding 2-(1H-indol/pyrrol-1-yl)anilines promoted by molecular iodine in good to excellent yields.


2018 ◽  
Vol 16 (30) ◽  
pp. 5533-5538 ◽  
Author(s):  
Xuefeng He ◽  
Yongsu Li ◽  
Meng Wang ◽  
Hui-Xuan Chen ◽  
Bin Chen ◽  
...  

Employing salicylic acids and substituted 3-butyn-2-ones as the substrates, a morpholine catalyzed tandem dual Michael addition afforded a benzodioxin skeleton.


2019 ◽  
Vol 55 (55) ◽  
pp. 7986-7989 ◽  
Author(s):  
Pengbing Mi ◽  
Jiajia Lang ◽  
Shaojian Lin

A highly efficient synthesis of monosubstituted pyrazoles from alkynes and N-isocyanoiminotriphenylphosphorane (NITTP) is developed via molybdenum-silver co-catalyzed [3+2] cycloaddition.


2014 ◽  
Vol 34 (1) ◽  
pp. 243-250
Author(s):  
Jianghong DING ◽  
Le XU ◽  
Hao XU ◽  
Haihong WU ◽  
Yueming LIU ◽  
...  

2013 ◽  
Vol 17 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Jadwiga Soloducho ◽  
Joanna Cabaj ◽  
Kamila Olech ◽  
Przemyslaw Data ◽  
Mieczyslaw Lapkowski

2011 ◽  
Vol 24 (6) ◽  
pp. 745-752 ◽  
Author(s):  
Song-bai Qiu ◽  
Yong Xu ◽  
Tong-qi Ye ◽  
Fei-yan Gong ◽  
Zhi Yang ◽  
...  

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