Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

2015 ◽  
Vol 54 (25) ◽  
pp. 7381-7385 ◽  
Author(s):  
Jin-Sheng Yu ◽  
Fu-Min Liao ◽  
Wei-Ming Gao ◽  
Kui Liao ◽  
Run-Lin Zuo ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Quaternary Carbon ◽  
Enol Ethers ◽  
Silyl Enol Ethers

Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

2015 ◽  
Vol 127 (25) ◽  
pp. 7489-7493 ◽  
Author(s):  
Jin-Sheng Yu ◽  
Fu-Min Liao ◽  
Wei-Ming Gao ◽  
Kui Liao ◽  
Run-Lin Zuo ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Quaternary Carbon ◽  
Enol Ethers ◽  
Silyl Enol Ethers

Highly efficient synthesis of benzodioxins with a 2-site quaternary carbon structure by secondary amine-catalyzed dual Michael cascade reactions

2018 ◽  
Vol 16 (30) ◽  
pp. 5533-5538 ◽  
Author(s):  
Xuefeng He ◽  
Yongsu Li ◽  
Meng Wang ◽  
Hui-Xuan Chen ◽  
Bin Chen ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Quaternary Carbon ◽  
Carbon Structure ◽  
Highly Efficient ◽  
Salicylic Acids

Employing salicylic acids and substituted 3-butyn-2-ones as the substrates, a morpholine catalyzed tandem dual Michael addition afforded a benzodioxin skeleton.

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