Manganese(ii) complexes with the non-steroidal anti-inflammatory drugs naproxen and mefenamic acid: synthesis, structure, antioxidant capacity, and interaction with albumins and DNA

2018 ◽  
Vol 42 (20) ◽  
pp. 16666-16681 ◽  
Author(s):  
Filitsa Dimiza ◽  
Catherine P. Raptopoulou ◽  
Vassilis Psycharis ◽  
Athanasios N. Papadopoulos ◽  
George Psomas
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Mefenamic Acid ◽  
Acid Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The structure, antioxidant activity and interaction with DNA and albumins of a series of manganese(ii) complexes of mefenamic acid or naproxen are presented herein.

Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: solubility and membrane permeability studies

CrystEngComm ◽  
2018 ◽  
Vol 20 (41) ◽  
pp. 6420-6429 ◽  
Author(s):  
Biswajit Bhattacharya ◽  
Amit Mondal ◽  
Saundray Raj Soni ◽  
Susobhan Das ◽  
Surojit Bhunia ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mefenamic Acid ◽  
Dissolution Properties ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Permeability Studies ◽  
Salt Forms

Dissolution properties and membrane permeability studies were conducted for four newly prepared multidrug salts of norfloxacin with four NSAIDs, diclofenac, diflunisal, mefenamic acid and indomethacin.

Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity

2014 ◽  
Vol 43 (28) ◽  
pp. 10930-10939 ◽  
Author(s):  
Jie Feng ◽  
Xin Du ◽  
Hui Liu ◽  
Xin Sui ◽  
Chen Zhang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Mefenamic Acid ◽  
Inhibitory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The coordination of non-steroidal anti-inflammatory drugs (NSAIDs) to metal ions could improve the pharmaceutical efficacy of NSAIDs due to the unique characteristics of metal complexes.

scholarly journals Development, Characterization and Pharmacological Investigation of Umbelliferone Conjugates of NSAIDs

2021 ◽  
Vol 30 (1) ◽  
pp. 240-248
Author(s):  
NIJA B ◽  
Arun Rasheed ◽  
A Kottaimuthu
Keyword(s):  
Mefenamic Acid ◽  
Protective Action ◽  
Chemical Characterization ◽  
Parent Drug ◽  
Brain Targeting ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ester Prodrug ◽  
Ester Prodrugs

The present investigation developed the ester prodrugs of Non-steroidal anti inflammatory drugs (NSAIDs), Mefenamic acid and Flurbiprofen by conjugating with the natural antioxidant, 4-methyl umbelliferone that resulted the formation of Mefenamic acid-umbelliferone ester prodrug and Flurbiprofen-umbelliferone ester prodrug .The principal objective this study is the synthesis of the ester prodrugs of NSAIDs with the enhanced therapeutic activity and minimized side effects. Prodrugs were synthesized by coupling method using N,N’- dicyclohexylcarbodiimide/4-dimethylaminopyrimidine, subjected to  physical, chemical characterization, spectral characterization (IR, 1H NMR, 13C NMR and Mass spectra),hydrolysis-kinetic study and pharmacological evaluation such as anti-inflammatory, ulcerogenecity as well as the effect of the NSAIDs in the central nervous system against degenerative mechanisms. The current study revealed that the umbelliferone conjugates of NSAIDs which upon administration would release the parent drug as a result of enzymatic or non-enzymatic hydrolysis in the desired site with enhanced anti inflammatory activity and reduction in the gastro intestinal toxicity. Also the synthesized pordrugs showed enhanced brain targeting efficiency with protective action against the degenerative processes.

scholarly journals Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 370-379 ◽  
Author(s):  
Eloi M. Lago ◽  
Marcos P. Silva ◽  
Talita G. Queiroz ◽  
Susana F. Mazloum ◽  
Vinícius C. Rodrigues ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Phenotypic Screening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Manganese (II)-imidazole complexes of the non-steroidal anti-inflammatory drug mefenamic acid: Synthesis, and structural studies

2020 ◽  
Vol 512 ◽  
pp. 119878 ◽  
Author(s):  
Aarti Borkar ◽  
Ginikachukwu G. Nnabuike ◽  
Joshua Ayoola Obaleye ◽  
Shital Harihar ◽  
Archana S. Patil ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Acid Synthesis ◽  
Structural Studies ◽  
Inflammatory Drug ◽  
Imidazole Complexes ◽  
Anti Inflammatory
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