Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: solubility and membrane permeability studies

CrystEngComm ◽  
2018 ◽  
Vol 20 (41) ◽  
pp. 6420-6429 ◽  
Author(s):  
Biswajit Bhattacharya ◽  
Amit Mondal ◽  
Saundray Raj Soni ◽  
Susobhan Das ◽  
Surojit Bhunia ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mefenamic Acid ◽  
Dissolution Properties ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Permeability Studies ◽  
Salt Forms

Dissolution properties and membrane permeability studies were conducted for four newly prepared multidrug salts of norfloxacin with four NSAIDs, diclofenac, diflunisal, mefenamic acid and indomethacin.

Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity

2014 ◽  
Vol 43 (28) ◽  
pp. 10930-10939 ◽  
Author(s):  
Jie Feng ◽  
Xin Du ◽  
Hui Liu ◽  
Xin Sui ◽  
Chen Zhang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Mefenamic Acid ◽  
Inhibitory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The coordination of non-steroidal anti-inflammatory drugs (NSAIDs) to metal ions could improve the pharmaceutical efficacy of NSAIDs due to the unique characteristics of metal complexes.

scholarly journals Development, Characterization and Pharmacological Investigation of Umbelliferone Conjugates of NSAIDs

2021 ◽  
Vol 30 (1) ◽  
pp. 240-248
Author(s):  
NIJA B ◽  
Arun Rasheed ◽  
A Kottaimuthu
Keyword(s):  
Mefenamic Acid ◽  
Protective Action ◽  
Chemical Characterization ◽  
Parent Drug ◽  
Brain Targeting ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ester Prodrug ◽  
Ester Prodrugs

The present investigation developed the ester prodrugs of Non-steroidal anti inflammatory drugs (NSAIDs), Mefenamic acid and Flurbiprofen by conjugating with the natural antioxidant, 4-methyl umbelliferone that resulted the formation of Mefenamic acid-umbelliferone ester prodrug and Flurbiprofen-umbelliferone ester prodrug .The principal objective this study is the synthesis of the ester prodrugs of NSAIDs with the enhanced therapeutic activity and minimized side effects. Prodrugs were synthesized by coupling method using N,N’- dicyclohexylcarbodiimide/4-dimethylaminopyrimidine, subjected to  physical, chemical characterization, spectral characterization (IR, 1H NMR, 13C NMR and Mass spectra),hydrolysis-kinetic study and pharmacological evaluation such as anti-inflammatory, ulcerogenecity as well as the effect of the NSAIDs in the central nervous system against degenerative mechanisms. The current study revealed that the umbelliferone conjugates of NSAIDs which upon administration would release the parent drug as a result of enzymatic or non-enzymatic hydrolysis in the desired site with enhanced anti inflammatory activity and reduction in the gastro intestinal toxicity. Also the synthesized pordrugs showed enhanced brain targeting efficiency with protective action against the degenerative processes.

scholarly journals Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 370-379 ◽  
Author(s):  
Eloi M. Lago ◽  
Marcos P. Silva ◽  
Talita G. Queiroz ◽  
Susana F. Mazloum ◽  
Vinícius C. Rodrigues ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Phenotypic Screening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Manganese(ii) complexes with the non-steroidal anti-inflammatory drugs naproxen and mefenamic acid: synthesis, structure, antioxidant capacity, and interaction with albumins and DNA

2018 ◽  
Vol 42 (20) ◽  
pp. 16666-16681 ◽  
Author(s):  
Filitsa Dimiza ◽  
Catherine P. Raptopoulou ◽  
Vassilis Psycharis ◽  
Athanasios N. Papadopoulos ◽  
George Psomas
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Mefenamic Acid ◽  
Acid Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The structure, antioxidant activity and interaction with DNA and albumins of a series of manganese(ii) complexes of mefenamic acid or naproxen are presented herein.

Aqueous chlorination of mefenamic acid: kinetics, transformation by-products and ecotoxicity assessment

2016 ◽  
Vol 18 (5) ◽  
pp. 555-561 ◽  
Author(s):  
Wan Nor Adira Wan Khalit ◽  
Kheng Soo Tay
Keyword(s):  
Mefenamic Acid ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
By Products

Mefenamic acid (Mfe) is one of the most frequently detected nonsteroidal anti-inflammatory drugs in the environment.

scholarly journals An experimental evaluation of anti-inflammatory activities of some combined NSAID preparations in albino rats

2017 ◽  
Vol 6 (4) ◽  
pp. 837
Author(s):  
Rajashekar Y. R. ◽  
Shobha S. N.
Keyword(s):  
Mefenamic Acid ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Albino Rats ◽  
Over The Counter ◽  
Rat Paw Edema ◽  
Dose Combination ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Rat Paw

Background: Non-steroidal anti-inflammatory drugs are among the most commonly used drugs across the globe and they are also available over the counter for minor symptoms of pain and inflammation. Their toxicity profile limits their continued usage and search is continuing for the better effective and safer agent.Methods: Interaction of paracetamol with diclofenac, ibuprofen and mefenamic acid were studied on carrageenan induced rat paw edema and cotton pellet induced granuloma models. Potentiation of these NSAIDs by paracetamol was also studied on same models.Results: Addition of paracetamol did not increase anti-inflammatory activity of diclofenac, ibuprofen and mefenamic acid in both acute and subacute models of inflammation. Paracetamol found to potentiate the ibuprofen action in anti-inflammatory model where as in subacute inflammatory model diclofenac action was potentited.Conclusions: Our study does not support the rationality of various fixed dose combination of NSAIDs with paracetamol available in market. Either NSAIDs to be used individually or their dose need to be decreased in fixed dose combination.

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