Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity

2014 ◽  
Vol 43 (28) ◽  
pp. 10930-10939 ◽  
Author(s):  
Jie Feng ◽  
Xin Du ◽  
Hui Liu ◽  
Xin Sui ◽  
Chen Zhang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Mefenamic Acid ◽  
Inhibitory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The coordination of non-steroidal anti-inflammatory drugs (NSAIDs) to metal ions could improve the pharmaceutical efficacy of NSAIDs due to the unique characteristics of metal complexes.

Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: solubility and membrane permeability studies

CrystEngComm ◽  
2018 ◽  
Vol 20 (41) ◽  
pp. 6420-6429 ◽  
Author(s):  
Biswajit Bhattacharya ◽  
Amit Mondal ◽  
Saundray Raj Soni ◽  
Susobhan Das ◽  
Surojit Bhunia ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mefenamic Acid ◽  
Dissolution Properties ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Permeability Studies ◽  
Salt Forms

Dissolution properties and membrane permeability studies were conducted for four newly prepared multidrug salts of norfloxacin with four NSAIDs, diclofenac, diflunisal, mefenamic acid and indomethacin.

Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions

1998 ◽  
Vol 71 (3-4) ◽  
pp. 171-179 ◽  
Author(s):  
Catherine Dendrinou-Samara ◽  
Georgia Tsotsou ◽  
Loucia V. Ekateriniadou ◽  
Alekos H. Kortsaris ◽  
Catherine P. Raptopoulou ◽  
...  
Keyword(s):  
Metal Ions ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Metal complexes of anti-inflammatory drugs—I. Complexes of iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) with 4-hydroxy-3-(5-methyl-3-is

Polyhedron ◽  
1985 ◽  
Vol 4 (4) ◽  
pp. 681-685 ◽  
Author(s):  
D.O Harrison ◽  
R. Thomas ◽  
A.E. Underhill ◽  
J.K. Fletcher ◽  
P.S. Gomm ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

A new screening system for nonsteroidal anti-inflammatory drugs based upon inhibition of chemiluminescence produced from human cells (granulocytes).

1979 ◽  
Vol 25 (9) ◽  
pp. 1655-1661 ◽  
Author(s):  
K Van Dyke ◽  
C Van Dyke ◽  
J Udeinya ◽  
C Brister ◽  
M Wilson
Keyword(s):  
Active Compound ◽  
Inhibitory Activity ◽  
Sodium Salicylate ◽  
Human Cells ◽  
Screening System ◽  
Phagocytic Cells ◽  
Inhibitory Potency ◽  
Prostaglandin Synthase ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract A new screening system for nonsteroidal anti-inflammatory drugs that involves use of human phagocytic cells has been developed in which chemiluminescence measurement is used. Luminol-dependent chemiluminescence is measured after the addition of opsonized (coated with antibodies and complement) zymosan particles to human granulocytic leukocytes in the presence or absence of drugs. Of all the compounds tested, indomethacin was the most potent in blocking chemiluminescence, with measurable inhibitory activity at 5 mumol/L. The order of inhibitory potency at 0.1 mmol/L and in the presence of Ca2+ and Mg2+ was indomethacin greater than sodium salicylate greater than fenoprofen Ca greater than tolmetin greater than naproxen greater than ibuprofen. It is likely that the active compound itself must be added to the system because aspirin did not inhibit chemiluminescence, whereas its metabolite, sodium salicylate, was markedly inhibitory. Dexamethasone and methylprednisolone also did not inhibit chemiluminescence. The drugs that inhibit chemiluminescence are also known inhibitors of prostaglandin synthase (cyclooxygenase portion).

scholarly journals Complexes With Biologically Active Ligands. Part 111. Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives

1998 ◽  
Vol 5 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Andrea Scozzafava ◽  
Christine Cavazza ◽  
Claudiu T. Supuran ◽  
Ioana Saramet ◽  
Fabrizio Briganti ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Nmr Spectroscopy ◽  
Animal Models ◽  
Carbonic Anhydrase ◽  
Metal Ions ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Inhibitory Activity ◽  
Biologically Active ◽  
Standard Procedures

Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the ligands were evidenced to interact with the metal ions in the prepared complexes. The original mercaptans and their metal complexes behave as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV, but did not lower intraocular pressure in rabbits in animal models of glaucoma.

METAL COMPLEXES OF ANTI-INFLAMMATORY DRUGS. PART II. AZAPROPAZONE COMPLEXES OF IRON(III), COBALT(II), NICKEL(II), COPPER(II) AND ZINC(II)

1985 ◽  
Vol 14 (2) ◽  
pp. 107-112 ◽  
Author(s):  
D. O. Harrison ◽  
R. Thomas ◽  
A. E. Underhill ◽  
F. A. Everall ◽  
P. S. Gomm ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document