scholarly journals Antitumor effects of melanin fromLachnumYM226 and its derivative in H22 tumor-bearing mice

MedChemComm ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 1059-1068 ◽  
Author(s):  
Fang Shi ◽  
Jinglei Li ◽  
Ziyang Ye ◽  
Liuqing Yang ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Antitumor Effects ◽  
Tumor Bearing

LM and ALM showed notable antitumor effect in H22 tumor-bearing mice and ALM was more effective.

Doxorubicin nanomedicine based on ginsenoside Rg1 with alleviated cardiotoxicity and enhanced antitumor activity

Nanomedicine ◽  
2021 ◽  
Vol 16 (29) ◽  
pp. 2587-2604
Author(s):  
Chaoqi Li ◽  
Xiangbo Gou ◽  
Hui Gao
Keyword(s):  
Antitumor Activity ◽  
Protective Effect ◽  
Tumor Targeting ◽  
Antitumor Effect ◽  
Ginsenoside Rg1 ◽  
Antitumor Effects ◽  
Tumor Bearing ◽  
Targeting Ability

Aim: The authors aimed to develop Dox@Rg1 nanoparticles with decreased cardiotoxicity to expand their application in cancer. Materials & methods: Dox@Rg1 nanoparticles were developed by encapsulating doxorubicin (Dox) in a self-assembled Rg1. The antitumor effect of the nanoparticles was estimated using 4T1 tumor-bearing mice and the protective effect on the heart was investigated in vitro and in vivo. Results: Different from Dox, the Dox@Rg1 nanoparticles induced increased cytotoxicity to tumor cells, which was decreased in cardiomyocytes by the inhibition of apoptosis. The study in vivo revealed that the Dox@Rg1 nanoparticles presented a perfect tumor-targeting ability and improved antitumor effects. Conclusion: Dox@Rg1 nanoparticles could enhance the antitumor effects and decrease the cardiotoxicity of Dox.

Synergistic Effect of Quercetin and Vitamin C in Reducing Acute Toxicity and Improving Antitumor Activity of Liposomal Doxorubicin

2019 ◽  
Vol 17 (2) ◽  
pp. 223-228
Author(s):  
Zhang Qianni ◽  
Liu Changjiang ◽  
Wang Junping
Keyword(s):  
Free Radicals ◽  
Antitumor Activity ◽  
Acute Toxicity ◽  
Vitamin C ◽  
Antitumor Effect ◽  
Liposomal Doxorubicin ◽  
Water Soluble ◽  
Antitumor Effects ◽  
Tumor Bearing ◽  
Water Soluble Vitamin

This article attempts to reduce the acute toxicity of doxorubicin while preserving its antitumor effects. For this purpose, a long-circulating liposomal doxorubicin was PEGylated to treat tumor-bearing Kunming mice, and quercetin and vitamin C were orally administered simultaneously to further suppress toxicity. Quercetin is a fat-soluble flavonoid that scavenges free radicals in cell membranes, whereas vitamin C is a water-soluble vitamin capable of neutralizing free radicals in the cytoplasm. Doxorubicin concentrations in the plasma and in the different organs of the mice were compared, and the detoxication effects of different combinations of reagents are discussed in detail. The results show that quercetin and vitamin C can synergistically reduce the acute toxicity of long-circulating liposomal doxorubicin and further improve its antitumor effect.

Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice

2018 ◽  
Vol 9 (2) ◽  
pp. 871-879 ◽  
Author(s):  
Shu-Ting Chan ◽  
Cheng-Hung Chuang ◽  
Yi-Chin Lin ◽  
Jiunn-Wang Liao ◽  
Chong-Kuei Lii ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Antitumor Effect ◽  
Muscle Wasting ◽  
Muscle Protein ◽  
Trichostatin A ◽  
Tumor Bearing ◽  
Muscle Protein Degradation

Quercetin prevents TSA-induced muscle wasting by down-regulating FOXO1 mediated muscle protein degradation.

scholarly journals Ganoderma formosanum Exopolysaccharides Inhibit Tumor Growth via Immunomodulation

2021 ◽  
Vol 22 (20) ◽  
pp. 11251
Author(s):  
Hsing-Chun Kuo ◽  
Yen-Wenn Liu ◽  
Chi-Chin Lum ◽  
Kai-Di Hsu ◽  
Shin-Ping Lin ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Carcinoma Cell ◽  
Culture Conditions ◽  
Lymphocyte Subpopulation ◽  
Mice Model ◽  
Cytokine Mrna ◽  
Antitumor Effects ◽  
Tumor Bearing ◽  
Therapeutic Model ◽  
Ganoderma Formosanum

Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.

Preparation of enzymatically highly active pegylated-D-amino acid oxidase and its application to antitumor therapy

2021 ◽  
Vol 18 ◽  
Author(s):  
Hideaki Nakamura ◽  
Appiah Enoch ◽  
Shotaro Iwaya ◽  
Sakura Furusho ◽  
Shoko Tsunoda ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Antitumor Effect ◽  
Tumor Tissue ◽  
Acid Oxidase ◽  
Antitumor Therapy ◽  
Amino Acid Oxidase ◽  
Tumor Bearing ◽  
Highly Active ◽  
High Enzyme ◽  
High Enzyme Activity

Background: D-amino acid oxidase (DAO) is an H2O2-generating enzyme, and tumor growth suppression by selective delivery of porcine DAO in tumors via the cytotoxic action of H2O2 has been reported. DAO isolated from Fusarium spp. (fDAO) shows much higher enzyme activity than porcine DAO, although the application of fDAO for antitumor treatment has not yet been determined. Objective: The purpose of this study was to prepare enzymatically highly active pegylated-fDAO, and to determine whether it accumulates in tumors and exerts a potent antitumor effect in tumor-bearing mice. Methods: Polyethylene glycol (PEG; Mw. 2000) was conjugated to fDAO to form PEGylated fDAO (PEG-fDAO). PEGfDAO was intravenously administered into S180 tumor-bearing mice, and the body distribution and antitumor activity of PEG-fDAO was determined. Results: The enzyme activity of PEG-fDAO was 26.1 U/mg, which was comparable to that of fDAO. Intravenously administered PEG-fDAO accumulated in tumors with less distribution in normal tissue except in the plasma. Enzyme activity in the tumor was 60–120 mU/g-tissue over 7–20 h after i.v. injection of 0.1 mg of PEG-fDAO. To generate the H2O2 in the tumor tissue, PEG-fDAO was intravenously administered, and then, D-phenylalanine was intraperitoneally administered after a lag time. No remarkable tumor suppression effect was observed under conditions used in this study, compared to the non-treated group. Conclusion: The results suggest that PEG-fDAO maintained high enzymatic activity after pegylation. Treatment with PEGfDAO conferred high enzyme activity on tumor tissue; 3–6 fold higher than that of previously reported pDAO; however, high enzyme activity in the plasma limited repeated treatment owing to lethal toxicity, which seemingly led to poor therapeutic outcome. Overall, the use of PEG-fDAO is promising for antitumor therapy, although the suppression of DAO activity in the plasma would also be required rather than only the increase in DAO activity in the tumor for an antitumor effect.

scholarly journals Antitumor Effect of a Novel Spiro-Acridine Compound is Associated with Up-Regulation of Th1-Type Responses and Antiangiogenic Action

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 29 ◽  
Author(s):  
Daiana K. Frade Silva ◽  
Sâmia S. Duarte ◽  
Thaís M. H. Lisboa ◽  
Rafael C. Ferreira ◽  
Ana Luíza de O. Lopes ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Tumor Cells ◽  
Antitumor Effect ◽  
Inflammatory Responses ◽  
Lethal Dose ◽  
Ehrlich Ascites Carcinoma ◽  
Antitumor Effects ◽  
Th2 Immune Response

Tumor cells have specific features, including angiogenesis induction, cell cycle dysregulation, and immune destruction evasion. By inducing a T helper type 2 (Th2) immune response, tumor cells may favor immune tolerance within the tumor, which allows progression of cancer growth. Drugs with potential antitumor activity are the spiro-acridines, which is a promising new class of acridine compounds. Herein, the novel spiro-acridine (E)-5′-oxo-1′-((3,4,5-trimethoxybenzylidene)amino)-1′,5′-dihydro-10H-spiro[acridine-9,2′-pyrrole]-4′-carbonitrile (AMTAC-17) was synthesized and tested for antitumor effects. Toxicity evaluation was performed in mice after acute treatment (2000 mg/kg, intraperitoneally, i.p.). The Ehrlich ascites carcinoma model was used to investigate the antitumor activity of AMTAC-17 (12.5, 25, or 50 mg/kg, i.p.) after seven days of treatment. Effects on the cell cycle, angiogenesis, and inflammatory responses were investigated. LD50 (lethal dose 50%) was estimated to be higher than 5000 mg/kg. AMTAC-17 reduced the Ehrlich tumor’s total viable cancer cells count and peritumoral micro-vessels density, and induced an increase in the sub-G1 peak. Additionally, there was an increase of Th1 cytokine profile levels (IL-1β, TNF-α, and IL-12). In conclusion, the spiro-acridine compound AMTAC-17 presents low toxicity, and its in vivo antitumor effect involves modulation of the immune system to a cytotoxic Th1 profile and a reduction of tumor angiogenesis.

Immune reaction of tumor-bearing mice to Propionibacterium acnes and the antitumor effect of the bacteria

1982 ◽  
Vol 14 (1) ◽  
Author(s):  
V. Silobrcic ◽  
G. Fredrickson ◽  
R. Sedlacek ◽  
H.D. Suit ◽  
G. Wolberg
Keyword(s):  
Antitumor Effect ◽  
Propionibacterium Acnes ◽  
Immune Reaction ◽  
Tumor Bearing

Polysaccharide from Eucheuma Gelatinae Enhance Immunocompetence against Murine H22 Tumor In Vivo

2014 ◽  
Vol 989-994 ◽  
pp. 1056-1059
Author(s):  
Juan Tang ◽  
Zhen Kong ◽  
Dong Yue Liu ◽  
An Jun Liu
Keyword(s):  
Flow Cytometry ◽  
Clinical Trials ◽  
Antitumor Effect ◽  
Biological Activities ◽  
Tumor Bearing

New antitumor strategies are underway and play important roles in clinical trials for combating cancer in future. Eucheuma gelatinae contains a certain amount of polysaccharides, which has various biological activities. In this study, the antitumor effect of Eucheuma gelatinae polysaccharide on murine H22 tumor bearing mice has been investigated. Histological stain, flow cytometry and other methods are applied to evaluate the effects of Eucheuma gelatinae polysaccharide on immunocompetence in vivo. The data indicates that Eucheuma gelatinae polysaccharide has antitumor effect in vivo by enhancing immunocompetence of the tumor bearers.

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