ganoderma formosanum
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2021 ◽  
Vol 22 (20) ◽  
pp. 11251
Author(s):  
Hsing-Chun Kuo ◽  
Yen-Wenn Liu ◽  
Chi-Chin Lum ◽  
Kai-Di Hsu ◽  
Shin-Ping Lin ◽  
...  

Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.


Mycobiology ◽  
2020 ◽  
Vol 48 (3) ◽  
pp. 219-227
Author(s):  
Cheng-Yen Chiang ◽  
Kai-Di Hsu ◽  
Yen-Yi Lin ◽  
Chang-Wei Hsieh ◽  
Jui-Ming Liu ◽  
...  

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kai-Di Hsu ◽  
Hong-Jhang Chen ◽  
Chi-Shin Wang ◽  
Chi-Chin Lum ◽  
Shu-Pei Wu ◽  
...  

2014 ◽  
Vol 98 (22) ◽  
pp. 9389-9398 ◽  
Author(s):  
Cheng-Li Wang ◽  
Chiu-Ying Lu ◽  
Ying-Chao Hsueh ◽  
Wen-Hsiung Liu ◽  
Chun-Jen Chen

Vaccine ◽  
2014 ◽  
Vol 32 (3) ◽  
pp. 401-408 ◽  
Author(s):  
Chia-Chen Pi ◽  
Ching-Liang Chu ◽  
Chu-Ying Lu ◽  
Yu-Jing Zhuang ◽  
Cheng-Li Wang ◽  
...  

1995 ◽  
Vol 47 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Jer-Min Lin ◽  
Chun-Ching Lin ◽  
Ming-Feng Chen ◽  
Takashi Ujiie ◽  
Atsushi Takada

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