scholarly journals Cross-talk between emulsion drops: how are hydrophilic reagents transported across oil phases?

Lab on a Chip ◽  
2018 ◽  
Vol 18 (24) ◽  
pp. 3903-3912 ◽  
Author(s):  
Gianluca Etienne ◽  
Antoine Vian ◽  
Marjan Biočanin ◽  
Bart Deplancke ◽  
Esther Amstad
Keyword(s):  
Cross Talk ◽  
Shell Thickness ◽  
Cross Contamination ◽  
Double Emulsions ◽  
Emulsion Drops

We demonstrate that small aqueous drops form in surfactant-containing oils that are in contact with aqueous phases. These drops transport even large reagents across oil shells of double emulsions, resulting in cross-contamination. This can be reduced by using appropriate surfactants or by reducing the shell thickness below 1 μm.

scholarly journals Scalable production of double emulsion drops with thin shells

Lab on a Chip ◽  
2018 ◽  
Vol 18 (13) ◽  
pp. 1936-1942 ◽  
Author(s):  
A. Vian ◽  
B. Reuse ◽  
E. Amstad
Keyword(s):  
High Throughput ◽  
Shell Thickness ◽  
Double Emulsion ◽  
Thin Shells ◽  
Double Emulsions ◽  
Emulsion Drops ◽  
Scalable Production

The microfluidic aspiration device reduces the shell thickness of double emulsions down to 240 nm at a high throughput.

scholarly journals Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions

Lab on a Chip ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 147-154 ◽  
Author(s):  
Saraf Nawar ◽  
Joshuah K. Stolaroff ◽  
Congwang Ye ◽  
Huayin Wu ◽  
Du Thai Nguyen ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Microfluidic Devices ◽  
Surface Wettability ◽  
Double Emulsions ◽  
Channel Surface ◽  
Emulsion Drops ◽  
Scalable Production

We present a multilayer dropmaker geometry that enables the modular fabrication of microfluidic devices containing precisely patterned channel surface wettability. The platform is used for the scalable production of uniform double emulsion drops.

scholarly journals Reducing the shell thickness of double emulsions using microfluidics

2016 ◽  
Vol 20 (12) ◽  
Author(s):  
Antoine Vian ◽  
Valentine Favrod ◽  
Esther Amstad
Keyword(s):  
Shell Thickness ◽  
Double Emulsions

scholarly journals Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 444 ◽  
Author(s):  
Jianhua Guo ◽  
Lihua Hou ◽  
Junpeng Hou ◽  
Jiali Yu ◽  
Qingming Hu
Keyword(s):  
Thin Shell ◽  
Shell Thickness ◽  
Double Emulsion ◽  
Spherical Shape ◽  
Thin Shells ◽  
Biomolecular Sensing ◽  
Oil In Water ◽  
Emulsion Drops ◽  
Long Term Observation

Microcapsules are attractive core-shell configurations for studies of controlled release, biomolecular sensing, artificial microbial environments, and spherical film buckling. However, the production of microcapsules with ultra-thin shells remains a challenge. Here we develop a simple and practical osmolarity-controlled swelling method for the mass production of monodisperse microcapsules with ultra-thin shells via water-in-oil-in-water (W/O/W) double-emulsion drops templating. The size and shell thickness of the double-emulsion drops are precisely tuned by changing the osmotic pressure between the inner cores and the suspending medium, indicating the practicability and effectiveness of this swelling method in tuning the shell thickness of double-emulsion drops and the resultant microcapsules. This method enables the production of microcapsules even with an ultra-thin shell less than hundreds of nanometers, which overcomes the difficulty in producing ultra-thin-shell microcapsules using the classic microfluidic emulsion technologies. In addition, the ultra-thin-shell microcapsules can maintain their intact spherical shape for up to 1 year without rupturing in our long-term observation. We believe that the osmolarity-controlled swelling method will be useful in generating ultra-thin-shell polydimethylsiloxane (PDMS) microcapsules for long-term encapsulation, and for thin film folding, buckling and rupturing investigation.

Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

2009 ◽  
pp. 090624002829090
Author(s):  
Tristan P. Learoyd ◽  
Jane L. Burrows ◽  
Eddie French ◽  
Peter C. Seville
Keyword(s):  
Sustained Delivery ◽  
Double Emulsions ◽  
Spray Dried

„Cross-talk“ zwischen Herz und Niere – das Kardiorenale Syndrom und seine Therapie aus der Sicht des Nephrologen

2009 ◽  
Vol 66 (11) ◽  
pp. 741-746 ◽  
Author(s):  
Stefan Farese
Keyword(s):  
Cross Talk

Herz und Nierenfunktion sind eng miteinander verknüpft. Ein Großteil der Patienten mit chronischer Herzinsuffizienz leidet gleichzeitig an einer Nierenfunktionsstörung. Diese ist kausal an der Entwicklung der Herzinsuffizienz beteiligt und stellt damit einen wichtigen prognostischen Faktor dar. Pathophysiologisch kommt es durch die verminderte renale Perfusion zu einer Aktivierung verschiedener Regelkreise, die eine Salz- und Wasserretention induzieren und damit das Fortschreiten der Herzinsuffizienz begünstigen. Therapeutische Ziele sind die Euvolämie sowie die kontrollierte Behandlung mittels prognostisch relevanter, kardialer Begleitmedikation. Können diese beiden Ziele aufgrund von Therapieresistenz, progredienter Niereninsuffizienz oder Therapie-Nebenwirkungen nicht erreicht werden, ist die Indikation für ein Nierenersatzverfahren gegeben. Prinzipiell können alle heute verfügbaren Verfahren angewendet werden. Die Auswahl der Modalität sollte jedoch an die individuelle Situation des Patienten angepasst und interdisziplinär besprochen werden. Obwohl sich unter Therapie bei allen Nierenersatzverfahren funktionelle und subjektive Verbesserungen nachweisen lassen, ist deren Einfluss auf die Langzeitprognose ungeklärt.

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