scholarly journals On-line reverse isotope dilution analysis for spatial quantification of elemental labels used in immunohistochemical assisted imaging mass spectrometry via LA-ICP-MS

2019 ◽  
Vol 34 (2) ◽  
pp. 407-412 ◽  
Author(s):  
David Clases ◽  
Raquel Gonzalez de Vega ◽  
Paul A. Adlard ◽  
Philip A. Doble

We present a novel on-line isotope dilution analysis (IDA) approach for the quantification of isotopically enriched metal labels used in immunohistochemical assisted imaging mass spectrometry.

2016 ◽  
Vol 31 (1) ◽  
pp. 270-279 ◽  
Author(s):  
David N. Douglas ◽  
Jennifer O'Reilly ◽  
Ciaran O'Connor ◽  
Barry L. Sharp ◽  
Heidi Goenaga-Infante

A strategy, systematically developed, is reported for the quantitative analysis of the Fe spatial distribution in biological tissue using laser ablation with ICP-MS and on-line double isotope dilution analysis.


1998 ◽  
Vol 70 (5) ◽  
pp. 1036-1040 ◽  
Author(s):  
August A. Specht ◽  
Diane Beauchemin

2019 ◽  
Vol 411 (16) ◽  
pp. 3553-3560 ◽  
Author(s):  
David Clases ◽  
Raquel Gonzalez de Vega ◽  
David Bishop ◽  
Philip Doble

2017 ◽  
Vol 51 (2) ◽  
pp. 157-165
Author(s):  
Le Zhang ◽  
Zhong-Yuan Ren ◽  
Jin-Long Ma ◽  
Xiao-Ping Xia

2016 ◽  
Vol 31 (9) ◽  
pp. 1846-1857 ◽  
Author(s):  
C. Brauckmann ◽  
C. Frank ◽  
D. Schulze ◽  
P. Kaiser ◽  
R. Stosch ◽  
...  

A species-specific ID-ICP-MS method for intact haemoglobin was developed applying an 57Fe enriched haemoglobin spike, which was prepared and characterised carefully.


2021 ◽  
Author(s):  
Andrew J. Mason ◽  
Anton Vaks ◽  
Sebastian F. M. Breitenbach ◽  
John N. Hooker ◽  
Gideon M. Henderson

Abstract. We describe a new method for the measurement of U/Pb ratios by isotope dilution multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) for the dating of geologically young clean carbonates, particularly speleothems. The method is intended for materials containing little or no initial 232Th. We illustrate and validate the method with four examples ranging from 0.57 Ma to 20 Ma old. The new method is capable of applying the 235U-207 and 238U-234U-206Pb chronometers, common Pb and quantifiable residual 234U/238U disequilibrium permitting. These provide an alternative to the more widely used 238U-206Pb chronometer, which can be highly inaccurate for samples a few million years old, owing to uncertainties in the excess initial 234U (hence, excess radiogenic 206Pb) commonly observed in speleothems.


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