Quantitation of the Fe spatial distribution in biological tissue by online double isotope dilution analysis with LA-ICP-MS: a strategy for estimating measurement uncertainty

2016 ◽  
Vol 31 (1) ◽  
pp. 270-279 ◽  
Author(s):  
David N. Douglas ◽  
Jennifer O'Reilly ◽  
Ciaran O'Connor ◽  
Barry L. Sharp ◽  
Heidi Goenaga-Infante
Keyword(s):  
Spatial Distribution ◽  
Quantitative Analysis ◽  
Laser Ablation ◽  
Measurement Uncertainty ◽  
Isotope Dilution ◽  
Biological Tissue ◽  
Isotope Dilution Analysis ◽  
Icp Ms ◽  
On Line ◽  
Double Isotope

A strategy, systematically developed, is reported for the quantitative analysis of the Fe spatial distribution in biological tissue using laser ablation with ICP-MS and on-line double isotope dilution analysis.

On-line double isotope dilution laser ablation inductively coupled plasma mass spectrometry for the quantitative analysis of solid materials

2014 ◽  
Vol 851 ◽  
pp. 64-71 ◽  
Author(s):  
Beatriz Fernández ◽  
Pablo Rodríguez-González ◽  
J. Ignacio García Alonso ◽  
Julien Malherbe ◽  
Sergio García-Fonseca ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Laser Ablation ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
Solid Materials ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
On Line ◽  
Double Isotope

scholarly journals On-line reverse isotope dilution analysis for spatial quantification of elemental labels used in immunohistochemical assisted imaging mass spectrometry via LA-ICP-MS

2019 ◽  
Vol 34 (2) ◽  
pp. 407-412 ◽  
Author(s):  
David Clases ◽  
Raquel Gonzalez de Vega ◽  
Paul A. Adlard ◽  
Philip A. Doble
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Imaging Mass Spectrometry ◽  
Isotope Dilution Analysis ◽  
Icp Ms ◽  
On Line

We present a novel on-line isotope dilution analysis (IDA) approach for the quantification of isotopically enriched metal labels used in immunohistochemical assisted imaging mass spectrometry.

Automated On-Line Isotope Dilution Analysis with ICP-MS Using Sandwich Flow Injection

1998 ◽  
Vol 70 (5) ◽  
pp. 1036-1040 ◽  
Author(s):  
August A. Specht ◽  
Diane Beauchemin
Keyword(s):  
Flow Injection ◽  
Isotope Dilution ◽  
Isotope Dilution Analysis ◽  
Icp Ms ◽  
On Line

scholarly journals SEC-ICP-MS and on-line isotope dilution analysis for characterisation and quantification of immunochemical assays

2019 ◽  
Vol 411 (16) ◽  
pp. 3553-3560 ◽  
Author(s):  
David Clases ◽  
Raquel Gonzalez de Vega ◽  
David Bishop ◽  
Philip Doble
Keyword(s):  
Isotope Dilution ◽  
Isotope Dilution Analysis ◽  
Icp Ms ◽  
On Line

Correction of mass fractionation for isotope dilution analysis by MC-ICP-MS

2017 ◽  
Vol 51 (2) ◽  
pp. 157-165
Author(s):  
Le Zhang ◽  
Zhong-Yuan Ren ◽  
Jin-Long Ma ◽  
Xiao-Ping Xia
Keyword(s):  
Isotope Dilution ◽  
Isotope Dilution Analysis ◽  
Mass Fractionation ◽  
Icp Ms

scholarly journals Quantitative Determination of the Surface Distribution of Supported Metal Nanoparticles: A Laser Ablation–ICP–MS Based Approach

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 77
Author(s):  
Davide Spanu ◽  
Gilberto Binda ◽  
Marcello Marelli ◽  
Laura Rampazzi ◽  
Sandro Recchia ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Laser Ablation ◽  
Quantitative Determination ◽  
Metal Nanoparticles ◽  
Total Mass ◽  
Functional Materials ◽  
Metal Extraction ◽  
Ms Analysis ◽  
Icp Ms

A laser ablation–inductively coupled plasma–mass spectrometry (LA–ICP–MS) based method is proposed for the quantitative determination of the spatial distribution of metal nanoparticles (NPs) supported on planar substrates. The surface is sampled using tailored ablation patterns and the data are used to define three-dimensional functions describing the spatial distribution of NPs. The volume integrals of such interpolated surfaces are calibrated to obtain the mass distribution of Ag NPs by correlation with the total mass of metal as determined by metal extraction and ICP–MS analysis. Once this mass calibration is carried out on a sacrificial sample, quantifications can be performed over multiple samples by a simple micro-destructive LA–ICP–MS analysis without requiring the extraction/dissolution of metal NPs. The proposed approach is here tested using a model sample consisting of a low-density polyethylene (LDPE) disk decorated with silver NPs, achieving high spatial resolution over cm2-sized samples and very high sensitivity. The developed method is accordingly a useful analytical tool for applications requiring both the total mass and the spatial distribution of metal NPs to be determined without damaging the sample surface (e.g., composite functional materials and NPs, decorated catalysts or electrodic materials).

Sign in / Sign up

Export Citation Format

Share Document