Increased intake of vitamin B12, folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy

2018 ◽  
Vol 9 (7) ◽  
pp. 3872-3883 ◽  
Author(s):  
Nisha Kemse ◽  
Anvita Kale ◽  
Preeti Chavan-Gautam ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Docosahexaenoic Acid ◽  
Vitamin B12 ◽  
Cognitive Performance ◽  
Vitamin B ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Induced Hypertension

Vitamin B12, folic acid, and docosahexaenoic acid levels are reported to be altered in women with preeclampsia.

A combined supplementation of vitamin B12and omega-3 fatty acids across two generations improves cardiometabolic variables in rats

2016 ◽  
Vol 7 (9) ◽  
pp. 3910-3919 ◽  
Author(s):  
Amrita Khaire ◽  
Richa Rathod ◽  
Karuna Randhir ◽  
Anvita Kale ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Docosahexaenoic Acid ◽  
Carbon Cycle ◽  
Vitamin B ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Two Generations ◽  
Combined Supplementation

Our earlier studies indicate that micronutrients (vitamin B12, folic acid) and omega-3 fatty acids especially docosahexaenoic acid (DHA) are interlinked in one carbon cycle.

Maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids: Implications for neurodevelopmental risk in the rat offspring

2012 ◽  
Vol 34 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Suchitra Roy ◽  
Anvita Kale ◽  
Kamini Dangat ◽  
Pratiksha Sable ◽  
Asmita Kulkarni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Rat Offspring

Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring

2014 ◽  
Vol 36 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Suchitra Roy ◽  
Pratiksha Sable ◽  
Amrita Khaire ◽  
Karuna Randhir ◽  
Anvita Kale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Brain Oxidative Stress

scholarly journals Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Vinita Khot ◽  
Anvita Kale ◽  
Asmita Joshi ◽  
Preeti Chavan-Gautam ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Fatty Acid ◽  
Carbon Cycle ◽  
Vitamin B ◽  
Mrna Levels ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Genes Encoding ◽  
The One

We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in rat placenta. We hypothesize that these changes are mediated through micronutrient dependent regulation of enzymes in one carbon cycle. Pregnant dams were assigned to six dietary groups with varying folic acid and vitamin B12levels. Vitamin B12deficient groups were supplemented with omega-3 fatty acid. Placental mRNA levels of enzymes, levels of phospholipids, and glutathione were determined. Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control. Omega-3 supplementation normalized CBS and MTHFR mRNA levels. Increased placental phosphatidylethanolamine (PE), phosphatidylcholine (PC), in the same group was also observed. Our data suggests that adverse effects of a maternal micronutrient imbalanced diet may be due to differential regulation of key genes encoding enzymes in one carbon cycle and omega-3 supplementation may ameliorate most of these changes.

scholarly journals Omega-3 fatty acids and cardiovascular disease: epidemiology and effects on cardiometabolic risk factors

2014 ◽  
Vol 5 (9) ◽  
pp. 2004-2019 ◽  
Author(s):  
Trevor A. Mori
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Cardiometabolic Risk ◽  
Epidemiological Studies ◽  
Fish Oils ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Disease Epidemiology

Clinical and epidemiological studies provide support that the polyunsaturated omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid from fish and fish oils are cardioprotective, particularly in the setting of secondary prevention.

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