Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats

2012 ◽  
Vol 86 (1-2) ◽  
pp. 21-27 ◽  
Author(s):  
Nisha S. Wadhwani ◽  
Rupali R. Manglekar ◽  
Kamini D. Dangat ◽  
Asmita V. Kulkarni ◽  
Sadhana R. Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Fatty Acid ◽  
Vitamin B12 ◽  
Wistar Rats ◽  
Transport Proteins ◽  
Omega 3 Fatty Acids ◽  
Liver Fatty Acid ◽  
Omega 3 ◽  
Fatty Acid Desaturases

Increased intake of vitamin B12, folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy

2018 ◽  
Vol 9 (7) ◽  
pp. 3872-3883 ◽  
Author(s):  
Nisha Kemse ◽  
Anvita Kale ◽  
Preeti Chavan-Gautam ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Docosahexaenoic Acid ◽  
Vitamin B12 ◽  
Cognitive Performance ◽  
Vitamin B ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Induced Hypertension

Vitamin B12, folic acid, and docosahexaenoic acid levels are reported to be altered in women with preeclampsia.

Maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids: Implications for neurodevelopmental risk in the rat offspring

2012 ◽  
Vol 34 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Suchitra Roy ◽  
Anvita Kale ◽  
Kamini Dangat ◽  
Pratiksha Sable ◽  
Asmita Kulkarni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Rat Offspring

Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring

2014 ◽  
Vol 36 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Suchitra Roy ◽  
Pratiksha Sable ◽  
Amrita Khaire ◽  
Karuna Randhir ◽  
Anvita Kale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Brain Oxidative Stress

scholarly journals Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Vinita Khot ◽  
Anvita Kale ◽  
Asmita Joshi ◽  
Preeti Chavan-Gautam ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Fatty Acid ◽  
Carbon Cycle ◽  
Vitamin B ◽  
Mrna Levels ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Genes Encoding ◽  
The One

We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in rat placenta. We hypothesize that these changes are mediated through micronutrient dependent regulation of enzymes in one carbon cycle. Pregnant dams were assigned to six dietary groups with varying folic acid and vitamin B12levels. Vitamin B12deficient groups were supplemented with omega-3 fatty acid. Placental mRNA levels of enzymes, levels of phospholipids, and glutathione were determined. Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control. Omega-3 supplementation normalized CBS and MTHFR mRNA levels. Increased placental phosphatidylethanolamine (PE), phosphatidylcholine (PC), in the same group was also observed. Our data suggests that adverse effects of a maternal micronutrient imbalanced diet may be due to differential regulation of key genes encoding enzymes in one carbon cycle and omega-3 supplementation may ameliorate most of these changes.

scholarly journals Dietary Enrichment with Omega -3 Fatty Acid Potentiates Leptin Permeability through the Blood-Brain Barrier in Wistar Rats

2020 ◽  
pp. 1-10
Author(s):  
Ebuehi, Osaretin Albert Taiwo ◽  
Oyegoke, Enioluwayan ◽  
Ajagun-Ogunleye, Olufemi Mulkah ◽  
Olu-Taiwo, Adebola
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Lipid Profile ◽  
Blood Brain Barrier ◽  
Wistar Rats ◽  
Brain Barrier ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Serum Leptin ◽  
Omega 3 Fatty Acid

Obesity is an excessive accumulation of fat which causes several health implications. It is a risk factor for most disabilities and non-communicable diseases such as cardiovascular diseases, diabetes, cancer, neurodegenerative diseases, etc. The present study aimed to show the effect of short and long-term supplementation of an enriched diet with different concentrations of omega-3 fatty acid on cerebrospinal fluid (CSF), and serum leptin ratio, adiposity and lipid profile in albino Wistar rats. Serum-leptin ratios and indicators such as lipid profile, feed consumption, and adiposity index were obtained to ascertain the effect of the enriched diet on health and wellness. Forty Wistar rats divided into four groups of ten were used, comprising of five males and females; Groups A, B, C and D. The group A, the control, was fed with rat chow and water alone. Groups B, C and D were fed with rat chow supplemented with 10%, 20% and 40% omega-3 fatty acid respectively. The permeability of the blood-brain barrier (BBB) with leptin significantly increased across the experimental groups in a concentration-dependent manner. Practical Applications: Omega-3-fatty acids, also called polyunsaturated fatty acids are well known for their cardioprotective properties. ALA, α-linoleic acid, eicosapentanoic acid (EPA), and docosahexanoic acid (DHA) have been collectively referred to as omega-3 fatty acids. ALA, an essential fatty acid, can be converted into EPA and DHA. These polyunsaturated fatty acids (PUFA) are obtained from fish-oil and other kinds of seafood. Dietary consumption is essential for a better blood lipid profile and reduced risk for cardiovascular disease. In the present study, supplementation with omega-3 fatty acids improved blood-lipid profile, increased HDL which are essential in preventing obesity. Equally reported here is that concentrations of serum-leptin and CSF were used to derive the leptin ratio. There was also a significant decrease in the adiposity index across the groups. The feed consumption and CSF leptin were given as r=-0.46 for the short term diet, while r=0.34 for the long term diet group. Data of the study indicate that omega-3 fatty acid enrichment had a diminishing effect on both adiposity and appetite, but enhanced the permeability of leptin through the blood-brain barrier in the Wistar rats. The relevance of this study is that omega-3-fatty acid food supplementation could aid in weight management and assist in the prevention and control of obesity.

Sign in / Sign up

Export Citation Format

Share Document