Maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids: Implications for neurodevelopmental risk in the rat offspring

2012 ◽  
Vol 34 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Suchitra Roy ◽  
Anvita Kale ◽  
Kamini Dangat ◽  
Pratiksha Sable ◽  
Asmita Kulkarni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Rat Offspring

Increased intake of vitamin B12, folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy

2018 ◽  
Vol 9 (7) ◽  
pp. 3872-3883 ◽  
Author(s):  
Nisha Kemse ◽  
Anvita Kale ◽  
Preeti Chavan-Gautam ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Docosahexaenoic Acid ◽  
Vitamin B12 ◽  
Cognitive Performance ◽  
Vitamin B ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Induced Hypertension

Vitamin B12, folic acid, and docosahexaenoic acid levels are reported to be altered in women with preeclampsia.

Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring

2014 ◽  
Vol 36 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Suchitra Roy ◽  
Pratiksha Sable ◽  
Amrita Khaire ◽  
Karuna Randhir ◽  
Anvita Kale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Brain Oxidative Stress

Guidelines for the pre-conception period

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Folic Acid ◽  
Vitamin D Supplementation ◽  
Nutritional Requirements ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Balanced Diet ◽  
Oily Fish ◽  
Inadequate Nutrition

Where possible, pre-conception counselling is desirable for both prospective parents in order to address issues of lifestyle and nutrition so that pregnancy can proceed with the best possible start. If dieting is necessary this should be initiated as far in advance of the pregnancy as possible, because inadequate nutrition around the time of conception can influence the fetal growth trajectory and weight at birth. Regardless of BMI, women should also be encouraged to engage in regular aerobic exercise. Nutritional requirements in the pre-conception period include adequate amounts of oily fish to provide omega-3 fatty acids. All women planning a pregnancy should receive 400 #amp;#x00B5;g of folic acid daily, and vitamin B12 and vitamin D supplementation may be necessary, particular for vegetarians. Other vitamins and minerals should be considered, particularly iron and iodine, but most should be obtainable from a balanced diet. Harmful behaviours and environmental exposures should be avoided.

scholarly journals Maternal Dietary Intake of Omega-3 Fatty Acids Correlates Positively with Regional Brain Volumes in 1-Month-Old Term Infants

2019 ◽  
Vol 30 (4) ◽  
pp. 2057-2069 ◽  
Author(s):  
Sarah U Morton ◽  
Rutvi Vyas ◽  
Borjan Gagoski ◽  
Catherine Vu ◽  
Jonathan Litt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin B12 ◽  
Maternal Nutrition ◽  
Brain Regions ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Brain Volumes ◽  
Infant Brain

Abstract Maternal nutrition is an important factor for infant neurodevelopment. However, prior magnetic resonance imaging (MRI) studies on maternal nutrients and infant brain have focused mostly on preterm infants or on few specific nutrients and few specific brain regions. We present a first study in term-born infants, comprehensively correlating 73 maternal nutrients with infant brain morphometry at the regional (61 regions) and voxel (over 300 000 voxel) levels. Both maternal nutrition intake diaries and infant MRI were collected at 1 month of life (0.9 ± 0.5 months) for 92 term-born infants (among them, 54 infants were purely breastfed and 19 were breastfed most of the time). Intake of nutrients was assessed via standardized food frequency questionnaire. No nutrient was significantly correlated with any of the volumes of the 61 autosegmented brain regions. However, increased volumes within subregions of the frontal cortex and corpus callosum at the voxel level were positively correlated with maternal intake of omega-3 fatty acids, retinol (vitamin A) and vitamin B12, both with and without correction for postmenstrual age and sex (P < 0.05, q < 0.05 after false discovery rate correction). Omega-3 fatty acids remained significantly correlated with infant brain volumes after subsetting to the 54 infants who were exclusively breastfed, but retinol and vitamin B12 did not. This provides an impetus for future larger studies to better characterize the effect size of dietary variation and correlation with neurodevelopmental outcomes, which can lead to improved nutritional guidance during pregnancy and lactation.

A combined supplementation of vitamin B12and omega-3 fatty acids across two generations improves cardiometabolic variables in rats

2016 ◽  
Vol 7 (9) ◽  
pp. 3910-3919 ◽  
Author(s):  
Amrita Khaire ◽  
Richa Rathod ◽  
Karuna Randhir ◽  
Anvita Kale ◽  
Sadhana Joshi
Keyword(s):  
Fatty Acids ◽  
Folic Acid ◽  
Docosahexaenoic Acid ◽  
Carbon Cycle ◽  
Vitamin B ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Two Generations ◽  
Combined Supplementation

Our earlier studies indicate that micronutrients (vitamin B12, folic acid) and omega-3 fatty acids especially docosahexaenoic acid (DHA) are interlinked in one carbon cycle.

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