Dearomative cycloadditions of a silylene with pyrazine and quinoxaline

2018 ◽  
Vol 47 (33) ◽  
pp. 11317-11321 ◽  
Author(s):  
Shintaro Ishida ◽  
Tomofumi Tamura ◽  
Takeaki Iwamoto
Keyword(s):  
Heterocyclic Compound ◽  
Membered Heterocyclic Compound

The dearomative cycloaddition of a dialkylsilylene with pyrazine affords an eight-membered heterocyclic compound with a trans-cycloalkene moiety.

scholarly journals A Scrupulous Review on Multifaceted Pyrazole Nucleus as an Energetic Pharmacological Agent

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Amala Babu ◽  
Sneha Antony ◽  
Femy Maria KM ◽  
Dr.Vinod B
Keyword(s):  
Heterocyclic Compound ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Point Of View ◽  
Pharmacological Agent ◽  
Inhibitory Effects ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Structural Point ◽  
Membered Heterocyclic Compound

Pyrazole represents a versatile class among heterocyclic compounds due to its impact in biological and pharmacological field irrespective of its scarcity in nature. From the structural point of view, pyrazoles are rather interesting and chemically it is known as 1,2-Diazoles.Also, it is a five membered heterocyclic compound containing 2 Nitrogen atoms. As per different studies, Pyrazoles and its derivatives own a wide range of biological activities like Antibacterial, Analgesic, Antioxidant etc. The main intention of this review is to run an overview of diverse pharmacological activities of pyrazole moiety especially antimicrobial, anti-inflammatory, antioxidant, analgesic, Hypoglycemic, anticancer and enzyme inhibitory effects.

Reactions of 1-Phenyl-1,2,3-triazolyllithium Compounds; Formation of Ketenimines, Alkynylamines, and Heterocycles from the Ambident (N-Phenyl)phenylketenimine Anion

1971 ◽  
Vol 49 (11) ◽  
pp. 1792-1798 ◽  
Author(s):  
R. Raap
Keyword(s):  
Methyl Iodide ◽  
Heterocyclic Compound ◽  
Room Temperature ◽  
Dimethyl Sulfate ◽  
Phenyl Isocyanate ◽  
Ambident Anion ◽  
Membered Heterocyclic Compound

At room temperature 1,4-diphenyl-1,2,3-triazolyllithium rapidly undergoes fragmentation to nitrogen and lithium (N-phenyl)phenylketenimine anion 8c, [Formula: see text]. Some of the reactions of this ambident anion have been studied. Reaction of 8c with methyl iodide results in C-methylation to a mixture of (N-phenyl)methylphenylketenimine and 3-methyl-1,3-diphenyl-4-(2′-phenylethylene)-2-phenyliminoazetidine. A six-membered heterocyclic compound, 6-anilino-1,3,5-triphenyluracil, results from the reaction between 8c and phenyl isocyanate. With dimethyl sulfate and methyl chloroformate N-alkylation and N-acylation takes place predominantly, forming N-methyl-N-phenyl-2-phenylethynylamine and N-carbomethoxy-N-phenyl-2-phenylethynylamine respectively. Reaction of 8c with methanol and ethanethiol gives an iminoester and an iminothioester respectively.1-Phenyl-1,2,3-triazolyllithium and 4-methyl-1-phenyl-1,2,3-triazolyllithium undergo fragmentation at somewhat higher temperatures.

scholarly journals Synthetic Approaches and Biological Significance of Oxazolone Moieties: A Review

2021 ◽  
Vol 12 (5) ◽  
pp. 6460-6486
Keyword(s):  
Heterocyclic Compound ◽  
Biological Significance ◽  
Antidiabetic Activity ◽  
Isomeric Form ◽  
Pharmacological Activities ◽  
Synthetic Routes ◽  
Synthetic Approaches ◽  
Anti Hiv ◽  
Heterocyclic Moiety ◽  
Membered Heterocyclic Compound

Oxazolone is a five-membered heterocyclic compound which is also known as azlactone. It contains one oxygen and one nitrogen as heteroatoms, which exist in five isomeric forms, according to the carbonyl group's location and the double bonds such as: 5 (4)-oxazolones, 5 (2) – oxazolones, 2 (3)-oxazolones, 4 (5)-oxazolones, and 2 (5)-oxazolones. 5 (4)-oxazolones is the most important heterocyclic moiety among all isomeric form of oxazolones. It is classified into two classes: saturated and unsaturated oxazolones. It is synthesized by various synthetic routes. Oxazolones are reported to exhibit various pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, anti-HIV, antiangiogenic, anticonvulsant, sedative, cardiotonic, antidiabetic activity, etc.

Multifunctional Hydantions: Recent Advances in Optoelectronics and in Medicinal drugs from Academia to Chemical Industry

2021 ◽  
Author(s):  
PRATIKSHA GAWAS ◽  
Buthanapalli Ramakrishna ◽  
Veeraiah Nalluri ◽  
Venkatramaiah Nutalapati
Keyword(s):  
Heterocyclic Compound ◽  
Chemical Industry ◽  
Recent Advances ◽  
Medicinal Drugs ◽  
Membered Heterocyclic Compound

Imidazilidine-2,4-dione, also well familiar as Hydantoin (TH) is one of the prominent five-membered heterocyclic compound with four versatile points of functionalities in its framework. Ever since the discovery of TH,...

Protective effect of a new heterocyclic compound on acute tracheobronchitis via reducing IL-6 and TNF-α content and PKA-NF-κB pathway activation

2021 ◽  
Vol 20 (1) ◽  
pp. 41-48
Author(s):  
Ai-Ping Han ◽  
Li Li
Keyword(s):  
Protective Effect ◽  
Heterocyclic Compound ◽  
Biological Study ◽  
Elisa Assay ◽  
Mice Model ◽  
X Ray ◽  
X Ray Crystallography ◽  
Pathway Activation ◽  
Tnf Α ◽  
Amino Benzoic Acid

The new heterocyclic compound 4-methyl-3-((4-(pyridin-3-yl) pyrimidin-2-yl) amino) benzoic acid (1) designed utilizing methyl 3-amino-4-methylbenzoate (2) as a starting material was successfully fabricated and eventually characterized utilizing single crystal X-ray crystallography, 1H NMR and IR. In biological study, to evaluate the protective effect of compound on acute tracheobronchitis ICR mice model, the ELISA assay was performed to determine the level of inflammatory mediators IL-6 and TNF-α in serum. Then, the western blot was performed to determine the activation of PKA-NF-κB pathway in tissues.

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

Synergistic lubricating effects of borate ester with heterocyclic compound

Wear ◽  
2000 ◽  
Vol 246 (1-2) ◽  
pp. 55-58 ◽  
Author(s):  
Guanqiu Shen ◽  
Zhi Zheng ◽  
Yong Wan ◽  
Xiangdong Xu ◽  
Lili Cao ◽  
...  
Keyword(s):  
Heterocyclic Compound ◽  
Borate Ester
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