Multifunctional Hydantions: Recent Advances in Optoelectronics and in Medicinal drugs from Academia to Chemical Industry

2021 ◽  
Author(s):  
PRATIKSHA GAWAS ◽  
Buthanapalli Ramakrishna ◽  
Veeraiah Nalluri ◽  
Venkatramaiah Nutalapati
Keyword(s):  
Heterocyclic Compound ◽  
Chemical Industry ◽  
Recent Advances ◽  
Medicinal Drugs ◽  
Membered Heterocyclic Compound

Imidazilidine-2,4-dione, also well familiar as Hydantoin (TH) is one of the prominent five-membered heterocyclic compound with four versatile points of functionalities in its framework. Ever since the discovery of TH,...

scholarly journals Direct Transamidation Reactions: Mechanism and Recent Advances

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2382 ◽  
Author(s):  
Paola Acosta-Guzmán ◽  
Alejandra Mateus-Gómez ◽  
Diego Gamba-Sánchez
Keyword(s):  
Carboxylic Acid ◽  
Chemical Industry ◽  
Metal Catalysts ◽  
Direct Reaction ◽  
Valuable Alternative ◽  
Recent Advances ◽  
Other Substances ◽  
Recent Developments ◽  
Nitrogen Nucleophiles ◽  
Reactions Mechanism

Amides are undeniably some of the most important compounds in Nature and the chemical industry, being present in biomolecules, materials, pharmaceuticals and many other substances. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, principally the use of stoichiometric activators or the need to use highly reactive carboxylic acid derivatives. In recent years, the transamidation reaction has emerged as a valuable alternative to prepare amides. The reactivity of amides makes their direct reaction with nitrogen nucleophiles difficult; thus, the direct transamidation reaction needs a catalyst in order to activate the amide moiety and to promote the completion of the reaction because equilibrium is established. In this review, we present research on direct transamidation reactions ranging from studies of the mechanism to the recent developments of more applicable and versatile methodologies, emphasizing those reactions involving activation with metal catalysts.

scholarly journals Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities

2019 ◽  
pp. 1-16
Author(s):  
Oluwaseyi Bukky Ovonramwen ◽  
Bodunde Joseph Owolabi ◽  
Amowie Philip Oviawe
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compound ◽  
Heterocyclic Compounds ◽  
Condensation Reaction ◽  
Review Article ◽  
Pharmacological Activities ◽  
Usual Approach ◽  
Recent Advances ◽  
Anti Cancer ◽  
Multifunctional Molecules

Chalcones are useful intermediates in the synthesis of heterocyclic compound and the unique reagents in organic synthesis. The usual approach to obtain chalcones is through Claisen-Schmidt condensation. Several novel heterocyclic chalcone analogs have emerged. Chalcones are multifunctional molecules that possess promising pharmacological activities. Chalcones are known for anti-cancer, antioxidant, anti-inflammatory, anti-microbial, anti-tubercular, antileishmanial, antimalarial, anthelmintic, osteogenic activities. This review article focuses on recent applications of Claisen-Schmidt condensation reaction employed in the synthesis of chalcone, its transformation to heterocyclic compounds and pharmacological activities.

Recent Advances in Synthesis of Benzoxazole

2020 ◽  
Vol 17 ◽  
Author(s):  
Shivani Bansal
Keyword(s):  
Heterocyclic Compound ◽  
Pharmacological Activity ◽  
Important Class ◽  
Recent Advances ◽  
Wide Range ◽  
Synthetic Chemist

: Benzoxazole are an important class of the heterocyclic compound and display a wide range of pharmacological activity and other applications. Due to their varied application, it is always an important moiety for the synthetic chemist to developed newer methodologies for their synthesis. In this review I have tried to concise and summarize all of the available methods for the preparation of benzoxazole, their substitutes and also discuss about their functionlization.

scholarly journals Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

2014 ◽  
Vol 2014 ◽  
pp. 1-21 ◽  
Author(s):  
Norman Ratcliffe ◽  
Patricia Azambuja ◽  
Cicero Brasileiro Mello
Keyword(s):  
Natural Products ◽  
Antimicrobial Peptides ◽  
Folk Medicine ◽  
Environmental Perturbations ◽  
Recent Advances ◽  
Blood Sucking ◽  
The World ◽  
Problems And Solutions ◽  
Treasure Chest ◽  
Medicinal Drugs

Except for honey as food, and silk for clothing and pollination of plants, people give little thought to the benefits of insects in their lives. This overview briefly describes significant recent advances in developing insect natural products as potential new medicinal drugs. This is an exciting and rapidly expanding new field since insects are hugely variable and have utilised an enormous range of natural products to survive environmental perturbations for 100s of millions of years. There is thus a treasure chest of untapped resources waiting to be discovered. Insects products, such as silk and honey, have already been utilised for thousands of years, and extracts of insects have been produced for use in Folk Medicine around the world, but only with the development of modern molecular and biochemical techniques has it become feasible to manipulate and bioengineer insect natural products into modern medicines. Utilising knowledge gleaned from Insect Folk Medicines, this review describes modern research into bioengineering honey and venom from bees, silk, cantharidin, antimicrobial peptides, and maggot secretions and anticoagulants from blood-sucking insects into medicines. Problems and solutions encountered in these endeavours are described and indicate that the future is bright for new insect derived pharmaceuticals treatments and medicines.

ChemInform Abstract: Recent Advances of Pore System Construction in Zeolite-Catalyzed Chemical Industry Processes

ChemInform ◽  
2016 ◽  
Vol 47 (6) ◽  
pp. no-no
Author(s):  
Jing Shi ◽  
Yangdong Wang ◽  
Weimin Yang ◽  
Yi Tang ◽  
Zaiku Xie
Keyword(s):  
Chemical Industry ◽  
System Construction ◽  
Pore System ◽  
Recent Advances

Formic Acid as an Inexpensive and Convenient Reagent

2020 ◽  
Vol 24 ◽  
Author(s):  
Xiao-hua CAI ◽  
Su-qian CAI ◽  
Bing XIE
Keyword(s):  
Formic Acid ◽  
Green Synthesis ◽  
Chemical Industry ◽  
Hydrogen Donor ◽  
Organic Reactions ◽  
The Past ◽  
Recent Advances ◽  
Versatile Reagent

Abstract:: Formic acid (HCOOH) as an inexpensive and versatile reagent has attracted broad attention in the field of green synthesis and chemical industry. Formic acid acts not only as a convenient and less toxic CO surrogate, but also as an excel-lent formylative reagent, C1 source and hydrogen donor in organic reactions. Over the past decades, many exciting contribu-tions have been made which have helped chemists to understand the mechanisms of these reactions. The review will exam-ine recent advances in the utilization of formic acid as economical, practical and multipurpose reactant in synthetic trans-formations.

scholarly journals Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review

RSC Advances ◽  
2020 ◽  
Vol 10 (35) ◽  
pp. 20784-20793 ◽  
Author(s):  
Abdanne Weyesa ◽  
Endale Mulugeta
Keyword(s):  
Organic Chemistry ◽  
Heterocyclic Compound ◽  
Synthetic Organic Chemistry ◽  
Recent Advances

Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry.

scholarly journals A Scrupulous Review on Multifaceted Pyrazole Nucleus as an Energetic Pharmacological Agent

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Amala Babu ◽  
Sneha Antony ◽  
Femy Maria KM ◽  
Dr.Vinod B
Keyword(s):  
Heterocyclic Compound ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Point Of View ◽  
Pharmacological Agent ◽  
Inhibitory Effects ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Structural Point ◽  
Membered Heterocyclic Compound

Pyrazole represents a versatile class among heterocyclic compounds due to its impact in biological and pharmacological field irrespective of its scarcity in nature. From the structural point of view, pyrazoles are rather interesting and chemically it is known as 1,2-Diazoles.Also, it is a five membered heterocyclic compound containing 2 Nitrogen atoms. As per different studies, Pyrazoles and its derivatives own a wide range of biological activities like Antibacterial, Analgesic, Antioxidant etc. The main intention of this review is to run an overview of diverse pharmacological activities of pyrazole moiety especially antimicrobial, anti-inflammatory, antioxidant, analgesic, Hypoglycemic, anticancer and enzyme inhibitory effects.

Reactions of 1-Phenyl-1,2,3-triazolyllithium Compounds; Formation of Ketenimines, Alkynylamines, and Heterocycles from the Ambident (N-Phenyl)phenylketenimine Anion

1971 ◽  
Vol 49 (11) ◽  
pp. 1792-1798 ◽  
Author(s):  
R. Raap
Keyword(s):  
Methyl Iodide ◽  
Heterocyclic Compound ◽  
Room Temperature ◽  
Dimethyl Sulfate ◽  
Phenyl Isocyanate ◽  
Ambident Anion ◽  
Membered Heterocyclic Compound

At room temperature 1,4-diphenyl-1,2,3-triazolyllithium rapidly undergoes fragmentation to nitrogen and lithium (N-phenyl)phenylketenimine anion 8c, [Formula: see text]. Some of the reactions of this ambident anion have been studied. Reaction of 8c with methyl iodide results in C-methylation to a mixture of (N-phenyl)methylphenylketenimine and 3-methyl-1,3-diphenyl-4-(2′-phenylethylene)-2-phenyliminoazetidine. A six-membered heterocyclic compound, 6-anilino-1,3,5-triphenyluracil, results from the reaction between 8c and phenyl isocyanate. With dimethyl sulfate and methyl chloroformate N-alkylation and N-acylation takes place predominantly, forming N-methyl-N-phenyl-2-phenylethynylamine and N-carbomethoxy-N-phenyl-2-phenylethynylamine respectively. Reaction of 8c with methanol and ethanethiol gives an iminoester and an iminothioester respectively.1-Phenyl-1,2,3-triazolyllithium and 4-methyl-1-phenyl-1,2,3-triazolyllithium undergo fragmentation at somewhat higher temperatures.

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