Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

2019 ◽  
Vol 9 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Jian-Dong Zhang ◽  
Xiao-Xiao Yang ◽  
Qiao Jia ◽  
Jian-Wei Zhao ◽  
Li-Li Gao ◽  
...  
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Enantioselective Synthesis ◽  
System P ◽  
Cascade Biocatalysis ◽  
Asymmetric Ring Opening

Asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols via a cascade biocatalysis system.

scholarly journals Asymmetric ring-opening reaction of meso-epoxides with aromatic amines using homochiral metal–organic frameworks as recyclable heterogeneous catalysts

RSC Advances ◽  
2018 ◽  
Vol 8 (49) ◽  
pp. 28139-28146 ◽  
Author(s):  
Koichi Tanaka ◽  
Maya Kinoshita ◽  
Jun Kayahara ◽  
Yutaro Uebayashi ◽  
Kazusada Nakaji ◽  
...  
Keyword(s):  
Aromatic Amines ◽  
Ring Opening ◽  
Heterogeneous Catalysts ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Amino Alcohols ◽  
Ring Opening Reaction ◽  
Ring Opening Reactions ◽  
Metal Organic ◽  
Asymmetric Ring Opening

Asymmetric ring-opening reactions of meso-epoxides by aromatic amines were achieved by using some chiral metal–organic frameworks. The corresponding β-amino alcohols were obtained with good yields and enantioselectivities (up to 97% ee).

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