An introduction to zwitterionic polymer behavior and applications in solution and at surfaces

2019 ◽  
Vol 48 (3) ◽  
pp. 757-770 ◽  
Author(s):  
Lewis D. Blackman ◽  
Pathiraja A. Gunatillake ◽  
Peter Cass ◽  
Katherine E. S. Locock
Keyword(s):  
Zwitterionic Polymers ◽  
Zwitterionic Polymer

Zwitterionic polymers, including polyampholytes and polybetaines, are polymers with both positive and negative charges incorporated into their structure.

scholarly journals P4VP Modified Zwitterionic Polymer for the Preparation of Antifouling Functionalized Surfaces

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 706 ◽  
Author(s):  
Chaoqun Wu ◽  
Yudan Zhou ◽  
Haitao Wang ◽  
Jianhua Hu
Keyword(s):  
Photoelectron Spectroscopy ◽  
Cell Attachment ◽  
Raft Polymerization ◽  
Polymer Brush ◽  
Contact Angles ◽  
Polymerization Process ◽  
Water Contact ◽  
Zwitterionic Polymers ◽  
Ito Glass ◽  
Zwitterionic Polymer

Zwitterionic polymers are suitable for replacing poly(ethylene glycol) (PEG) polymers because of their better antifouling properties, but zwitterionic polymers have poor mechanical properties, strong water absorption, and their homopolymers should not be used directly. To solve these problems, a reversible-addition fragmentation chain transfer (RAFT) polymerization process was used to prepare copolymers comprised of zwitterionic side chains that were attached to an ITO glass substrate using spin-casting. The presence of 4-vinylpyridine (4VP) and zwitterion chains on these polymer-coated ITO surfaces was confirmed using 1H NMR, FTIR, and GPC analyses, with successful surface functionalization confirmed using water contact angle, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) studies. Changes in water contact angles and C/O ratios (XPS) analysis demonstrated that the functionalization of these polymers with β-propiolactone resulted in hydrophilic mixed 4VP/zwitterionic polymers. Protein adsorption and cell attachment assays were used to optimize the ratio of the zwitterionic component to maximize the antifouling properties of the polymer brush surface. This work demonstrated that the antifouling surface coatings could be readily prepared using a “P4VP-modified” method, that is, the functionality of P4VP to modify the prepared zwitterionic polymer. We believe these materials are likely to be useful for the preparation of biomaterials for biosensing and diagnostic applications.

Bioinspired dopamine and zwitterionic polymers for non-fouling surface engineering

2021 ◽  
Author(s):  
Anika Benozir Asha ◽  
Yangjun Chen ◽  
Ravin Narain
Keyword(s):  
Medical Devices ◽  
Surface Engineering ◽  
Zwitterionic Polymers ◽  
Zwitterionic Polymer ◽  
Non Fouling

Conjugation of zwitterionic polymer with dopamine is a promising approach to endow the surface with antifouling properties for medical devices, biosensors and marine coating applications etc. Zwitterionic polymers can be conjugated with dopamine by mostly four methods.

scholarly journals Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion

2020 ◽  
Vol 117 (50) ◽  
pp. 32046-32055
Author(s):  
Ershuai Zhang ◽  
Boyi Song ◽  
Yuanjie Shi ◽  
Hui Zhu ◽  
Xiangfei Han ◽  
...  
Keyword(s):  
Protective Layer ◽  
Pelvic Surgery ◽  
Postoperative Adhesion ◽  
Postoperative Adhesions ◽  
Working Mechanism ◽  
Zwitterionic Polymers ◽  
Physical Barriers ◽  
Zwitterionic Polymer ◽  
Protein Cell ◽  
Prevention Approach

Postoperative adhesions are most common issues for almost any types of abdominal and pelvic surgery, leading to adverse consequences. Pharmacological treatments and physical barrier devices are two main approaches to address postoperative adhesions but can only alleviate or reduce adhesions to some extent. There is an urgent need for a reliable approach to completely prevent postoperative adhesions and to significantly improve the clinical outcomes, which, however, is unmet with current technologies. Here we report that by applying a viscous, cream-like yet injectable zwitterionic polymer solution to the traumatized surface, postoperative adhesion was completely and reliably prevented in three clinically relevant but increasingly challenging models in rats. The success rate of full prevention is over 93% among 42 animals tested, which is a major leap in antiadhesion performance. Clinically used Interceed film can hardly prevent the adhesion in any of these models. Unlike current antiadhesion materials serving solely as physical barriers, the “nonfouling” zwitterionic polymer functioned as a protective layer for antiadhesion applications with the inherent benefit of resisting protein/cell adhesions. The nonfouling nature of the polymer prevented the absorption of fibronectins and fibroblasts, which contribute to the initial and late-stage development of the adhesion, respectively. This is the key working mechanism that differentiated our “complete prevention” approach from current underperforming antiadhesion materials. This work implies a safe, effective, and convenient way to fully prevent postoperative adhesions suffered by current surgical patients.

scholarly journals De novo design of functional zwitterionic biomimetic material for immunomodulation

2020 ◽  
Vol 6 (22) ◽  
pp. eaba0754 ◽  
Author(s):  
Bowen Li ◽  
Zhefan Yuan ◽  
Priyesh Jain ◽  
Hsiang-Chieh Hung ◽  
Yuwei He ◽  
...  
Keyword(s):  
De Novo ◽  
Specific Interaction ◽  
De Novo Design ◽  
The Other ◽  
Trade Off ◽  
Zwitterionic Polymers ◽  
Zwitterionic Polymer ◽  
Nonspecific Interactions ◽  
Immunomodulatory Properties

Superhydrophilic zwitterionic polymers are a class of nonfouling materials capable of effectively resisting any nonspecific interactions with biological systems. We designed here a functional zwitterionic polymer that achieves a trade-off between nonspecific interactions providing the nonfouling property and a specific interaction for bioactive functionality. Built from phosphoserine, an immune-signaling molecule in nature, this zwitterionic polymer exhibits both nonfouling and immunomodulatory properties. Its conjugation to uricase is shown to proactively eradicate all unwanted immune response, outperforming the zwitterionic polymers. On the other hand, this polymer could significantly prolong the half-life of protein drugs in vivo, overcoming the innate drawback of phosphoserine in inducing accelerated clearance. Our demonstration of a nonfouling zwitterionic material with built-in immunomodulatory functionality provides new insights into the fundamental design of biomaterials, as well as far-reaching implications for broad applications such as drug delivery, implants, and cell therapy.

scholarly journals Application of Nanoscale Zwitterionic Polyelectrolytes Brush with High Stability and Quantum Yield in Aqueous Solution for Cell Imaging

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Zhiyong Zhang ◽  
Minqiang Tan ◽  
Linghui Kong ◽  
Xiaomei Lu ◽  
Pengfei Sun ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Water Solubility ◽  
Cationic Polymer ◽  
Side Chains ◽  
Zwitterionic Polymers ◽  
Zwitterionic Polymer ◽  
Low Cytotoxicity ◽  
Ph Range ◽  
Cationic Polyelectrolytes

Cationic and zwitterionic polyelectrolytes are synthesized through atom transfer radical polymerization (ATRP), comprising a polyfluorene backbone with a small fraction of 2,1,3-benzothiadiazole and poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) side chains. Due to higher charge density generated from grafted side chains, two polymers show higher water solubility and higher quantum yield. In comparison with cationic polyelectrolytes, zwitterionic polyelectrolytes are stable over a broad pH range from 1 to 13, even in 1 M NaCl solution. The absence of FRET between zwitterionic polymers and dye-labeled ssDNA indicates their ultralow nonspecific adsorption, while cationic polymer shows much stronger nonspecific interactions. The MTT assay of zwitterionic polymers exhibits their minimal cytotoxicity and potential in long-term clinical application. Most importantly, zwitterionic polymer could be efficiently taken up by cells, whereas cationic polymer stains the surface of cell due to membrane disruption generated from positive charges. The results illustrate that conjugated zwitterionic polymer could serve as a novel type of highly efficient ultralow fouling material with low cytotoxicity for labelling cell or potential biomedical applications.

Water Structure Change-Induced Expansion and Collapse of Zwitterionic Polymers Surface-Grafted onto Carbon Black

2014 ◽  
Vol 67 (11) ◽  
pp. 1706
Author(s):  
Yiwen Pei ◽  
Jadranka Travas-Sejdic ◽  
David E. Williams
Keyword(s):  
Carbon Black ◽  
Protein Stability ◽  
Polymer Brushes ◽  
Water Structure ◽  
Dipole Interaction ◽  
Structure Change ◽  
Zwitterionic Polymers ◽  
Zwitterionic Polymer

We demonstrate the expansion and collapse of surface-grafted zwitterionic polymer brushes in water caused by the addition of urea. We hypothesize that at low urea concentrations, this is an effect of an ion–dipole interaction between urea and the polymer, and at high urea concentrations, an effect of a change in water structure causing change in solvation of the brushes and hence a change in the dipole–dipole interaction, and that it is analogous to the effects of urea on protein stability.

Conductivity, Dielectric and Modulus study of NH4PF6 based Zwitterionic polymer electrolyte

2020 ◽  
Vol 13 ◽  
Author(s):  
Manindra Kumar ◽  
Neelabh Srivastava
Keyword(s):  
Polymer Electrolyte ◽  
Power Law ◽  
Loss Tangent ◽  
Electric Modulus ◽  
Relaxation Behavior ◽  
Conductivity Data ◽  
Frequency Range ◽  
Zwitterionic Polymer ◽  
Power Law Equation ◽  
Jonscher’S Power Law

Background and Objective: Zwitterionic polymer electrolyte has been successfully synthesized using NH4PF6 salt. The conductivity of the synthesized polymer membrane is found to be of the order of 10-3Scm-1. Dielectric and Modulus properties of the polymer electrolyte have also been studied which showed well relaxation peaks with both temperature and salt concentrations. Result: This is well depicted with the loss tangent curve. Debye type relaxation behavior has observed from the electric modulus. Conclusion: Frequency dependent conductivity data (fitted with Jonscher's power law equation) confirmed the presence of NCL/SLPL type behavior in the studied frequency range.

Functionalization of Polycarbonate Surfaces by Grafting PEG and Zwitterionic Polymers with a Multicomb Structure

2013 ◽  
Vol 13 (12) ◽  
pp. 1681-1688 ◽  
Author(s):  
Jing Yang ◽  
Juan Lv ◽  
Marc Behl ◽  
Andreas Lendlein ◽  
Dazhi Yang ◽  
...  
Keyword(s):  
Zwitterionic Polymers
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