Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics

2019 ◽  
Vol 55 (13) ◽  
pp. 1963-1966 ◽  
Author(s):  
Yu Luo ◽  
Yan Tang ◽  
Tianzhi Liu ◽  
Qian Chen ◽  
Xiaohan Zhou ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Tumor Microenvironment ◽  
Drug Release ◽  
On Demand ◽  
Cancer Theranostics ◽  
Smart Drug

An intelligent nanoplatform is constructed by conjugating cis-aconitic anhydride-modified doxorubicin to weakly crystallized, ultrasmall SPION loaded graphene oxide (GO) nanosheets. More importantly, the composites present ultrasensitive breakage hydrolysis induced by pH alteration, achieving on-demand, gradual drug release in the tumor microenvironment.

scholarly journals Hybrid Iron Oxide–Graphene Oxide–Polysaccharides Microcapsule: A Micro-Matryoshka for On-Demand Drug Release and Antitumor Therapy In Vivo

2016 ◽  
Vol 8 (11) ◽  
pp. 6859-6868 ◽  
Author(s):  
Lin Deng ◽  
Qiujin Li ◽  
Safa’a Al-Rehili ◽  
Haneen Omar ◽  
Abdulaziz Almalik ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Iron Oxide ◽  
Drug Release ◽  
Antitumor Therapy ◽  
On Demand

An Integrated Tumor Microenvironment Responsive Polymeric Micelle for Smart Drug Delivery and Effective Drug Release

2021 ◽  
Vol 32 (9) ◽  
pp. 2083-2094
Author(s):  
Nanxia Zhang ◽  
Weixing Liu ◽  
Zhipeng Dong ◽  
Yunxue Yin ◽  
Jun Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Drug Release ◽  
Polymeric Micelle ◽  
Effective Drug ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals On demand electrochemical release of drugs from porous reduced graphene oxide modified flexible electrodes

2017 ◽  
Vol 5 (32) ◽  
pp. 6557-6565 ◽  
Author(s):  
Samia Boulahneche ◽  
Roxana Jijie ◽  
Alexandre Barras ◽  
Fereshteh Chekin ◽  
Santosh K. Singh ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Reduced Graphene Oxide ◽  
Flexible Electrodes ◽  
On Demand ◽  
Reduced Graphene ◽  
Electrochemical Control

Despite the advantages of an electrochemical control of drug release, only a handful of electrochemical-based release systems have been developed so far.

Smart Drug Release Systems Based on Stimuli-Responsive Polymers

2013 ◽  
Vol 13 (9) ◽  
pp. 1369-1380 ◽  
Author(s):  
Guangyan Qing ◽  
Minmin Li ◽  
Lijing Deng ◽  
Ziyu Lv ◽  
Peng Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Smart Drug

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2351
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Release Rate ◽  
Composite System ◽  
Methyl Blue ◽  
Burst Release ◽  
Fluorescein Sodium ◽  
Photothermal Conversion ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

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