scholarly journals Hybrid Iron Oxide–Graphene Oxide–Polysaccharides Microcapsule: A Micro-Matryoshka for On-Demand Drug Release and Antitumor Therapy In Vivo

2016 ◽  
Vol 8 (11) ◽  
pp. 6859-6868 ◽  
Author(s):  
Lin Deng ◽  
Qiujin Li ◽  
Safa’a Al-Rehili ◽  
Haneen Omar ◽  
Abdulaziz Almalik ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Iron Oxide ◽  
Drug Release ◽  
Antitumor Therapy ◽  
On Demand

A spatiotemporal anticancer drug release platform of PEGylated graphene oxide triggered by glutathione in vitro and in vivo

2012 ◽  
Vol 22 (45) ◽  
pp. 23845 ◽  
Author(s):  
Uuriintuya Dembereldorj ◽  
Mira Kim ◽  
Semi Kim ◽  
Erdene-Ochir Ganbold ◽  
So Yeong Lee ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Anticancer Drug

scholarly journals S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Changping Wang ◽  
Chongyi Liu ◽  
Qiyao Wei ◽  
Lei Yang ◽  
Peng Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Visible Light ◽  
Cell Fate ◽  
Degradation Kinetics ◽  
Green Light ◽  
Anticancer Drug Delivery ◽  
On Demand ◽  
Facile Fabrication

Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties.

Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

Soft Matter ◽  
2012 ◽  
Vol 8 (5) ◽  
pp. 1623-1627 ◽  
Author(s):  
Stefan A. Rovers ◽  
Richard Hoogenboom ◽  
Maartje F. Kemmere ◽  
Jos T. F. Keurentjes
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
On Demand ◽  
Magnetic Heating ◽  
Polymeric Implants

Hierarchical construction of a mechanically stable peptide–graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo

Nanoscale ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 1655-1660 ◽  
Author(s):  
Junhua Wu ◽  
Aiping Chen ◽  
Meng Qin ◽  
Rong Huang ◽  
Guang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
High Stability ◽  
Control Release ◽  
Drug Control ◽  
Triggered Release ◽  
Hybrid Hydrogel ◽  
On Demand

A peptide–graphene oxide hybrid hydrogel that possesses high stability and drug-sustainability was engineered for on-demand drug control release.

scholarly journals Near-Infrared, Light-Triggered, On-Demand Anti-inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing

2019 ◽  
Vol 5 (4) ◽  
pp. 63 ◽  
Author(s):  
Mauro ◽  
Cavallaro ◽  
Giammona
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Cell Adhesion ◽  
Near Infrared ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Adhesion Properties ◽  
On Demand

Very recently, significant attention has been focused on the adsorption and cell adhesion properties of graphene oxide (GO), because it is expected to allow high drug loading and controlled drug release, as well as the promotion of cell adhesion and proliferation. This is particularly interesting in the promotion of wound healing, where antibiotics and anti-inflammatories should be locally released for a prolonged time to allow fibroblast proliferation. Here, we designed an implantable patch consisting of poly(caprolactone) electrospun covered with GO, henceforth named GO–PCL, endowed with high ibuprofen (5.85 mg cm−2), ketoprofen (0.86 mg cm−2), and vancomycin (0.95 mg cm−2) loading, used as anti-inflammatory and antibiotic models respectively, and capable of responding to near infrared (NIR)-light stimuli in order to promptly release the payload on-demand beyond three days. Furthermore, we demonstrated the GO is able to promote fibroblast adhesion, a key characteristic to potentially provide wound healing in vivo.

Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics

2019 ◽  
Vol 55 (13) ◽  
pp. 1963-1966 ◽  
Author(s):  
Yu Luo ◽  
Yan Tang ◽  
Tianzhi Liu ◽  
Qian Chen ◽  
Xiaohan Zhou ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Tumor Microenvironment ◽  
Drug Release ◽  
On Demand ◽  
Cancer Theranostics ◽  
Smart Drug

An intelligent nanoplatform is constructed by conjugating cis-aconitic anhydride-modified doxorubicin to weakly crystallized, ultrasmall SPION loaded graphene oxide (GO) nanosheets. More importantly, the composites present ultrasensitive breakage hydrolysis induced by pH alteration, achieving on-demand, gradual drug release in the tumor microenvironment.

scholarly journals On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 52 (16) ◽  
pp. 4384-4388 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Release System ◽  
On Demand ◽  
Drug Release System ◽  
Self Assembled

On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 125 (16) ◽  
pp. 4480-4484 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Release System ◽  
On Demand ◽  
Drug Release System ◽  
Self Assembled

scholarly journals In vivo visible light-triggered drug release from an implanted depot

2015 ◽  
Vol 6 (1) ◽  
pp. 335-341 ◽  
Author(s):  
Carl-Johan Carling ◽  
Mathieu L. Viger ◽  
Viet Anh Nguyen Huu ◽  
Arnold V. Garcia ◽  
Adah Almutairi
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Degradable Polymer ◽  
On Demand ◽  
Triggered Drug Release

A visible light-degradable polymer allows on-demand in vivo photorelease of encapsulated dexamethasone from a subcutaneously implanted particle depot.

scholarly journals pH-Responsive nanocomposite fibres allowing MRI monitoring of drug release

2020 ◽  
Vol 8 (32) ◽  
pp. 7264-7274 ◽  
Author(s):  
Ziwei Zhang ◽  
Connor J. R. Wells ◽  
Aaron M. King ◽  
Joseph C. Bear ◽  
Gemma-Louise Davies ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Oxide Nanoparticles ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Therapeutic Delivery ◽  
On Demand ◽  
Model Drug

pH-responsive nanofibres containing iron oxide nanoparticles (NPs) and a model drug demonstrate on-demand dissolution, triggering release of both drug and NPs and allowing magnetic resonance imaging-guided therapeutic delivery.

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