scholarly journals An oxaliplatin(iv) prodrug-based supramolecular self-delivery nanocarrier for targeted colorectal cancer treatment

2018 ◽  
Vol 54 (90) ◽  
pp. 12762-12765 ◽  
Author(s):  
Wei Qi Lim ◽  
Soo Zeng Fiona Phua ◽  
Hongzhong Chen ◽  
Yanli Zhao
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cell Targeting ◽  
Redox Responsive ◽  
Two Component ◽  
Cancer Cell Targeting ◽  
Colorectal Cancer Treatment

A two-component supramolecular prodrug nanocarrier fabricated via self-assembly presents redox-responsive drug release with cancer cell-targeting capability, showing enhanced efficiency for colorectal cancer treatment.

scholarly journals Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

RSC Advances ◽  
2021 ◽  
Vol 11 (26) ◽  
pp. 16131-16141
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Siti Nadiah Zulkifli ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Chemotherapeutic Agent ◽  
Cell Targeting ◽  
Specific Targeting ◽  
Colorectal Cancer Cells ◽  
Cancer Cell Targeting

5-FU-PEGylated AuNPs-CD133 is designed to improve specific targeting of 5-FU against colorectal cancer cells which abundantly express CD133.

scholarly journals Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 4952-4957
Author(s):  
Valeria Tagliavini ◽  
Claudia Honisch ◽  
Simona Serratì ◽  
Amalia Azzariti ◽  
Marcella Bonchio ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cell Targeting ◽  
Cancer Cell Targeting ◽  
Targeting Ability ◽  
Anionic Spacer

The introduction of a tailored hydrophilic/anionic spacer in an Anderson–Evans polyoxometalate, bis-conjugated with demobensin-1 peptide, fosters self-assembly into fibrillary nanostructures and an unprecedented cancer cell targeting ability.

scholarly journals Mesoporous silica nanoparticle-based intelligent drug delivery system for bienzyme-responsive tumour targeting and controlled release

2018 ◽  
Vol 5 (1) ◽  
pp. 170986 ◽  
Author(s):  
Yang Zhang ◽  
Juan Xu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cell ◽  
Silica Nanoparticle ◽  
Cell Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Cancer Cell Targeting

This paper proposes a novel type of multifunctional envelope-type mesoporous silica nanoparticle (MSN) to achieve cancer cell targeting and drug-controlled release. In this system, MSNs were first modified by active targeting moiety hyaluronic acid (HA) for breast cancer cell targeting and hyaluronidases (Hyal)-induced intracellular drug release. Then gelatin, a proteinaceous biopolymer, was grafted onto the MSNs to form a capping layer via glutaraldehyde-mediated cross-linking. To shield against unspecific uptake of cells and prolong circulation time, the nanoparticles were further decorated with poly(ethylene glycol) polymers (PEG) to obtain MSN@HA-gelatin-PEG (MHGP). Doxorubicin (DOX), as a model drug, was loaded into PEMSN to assess the breast cancer cell targeting and drug release behaviours. In vitro study revealed that PEG chains protect the targeting ligand and shield against normal cells. After reaching the breast cancer cells, MMP-2 overpressed by cells hydrolyses gelatin layer to deshield PEG and switch on the function of HA. As a result, DOX-loaded MHGP was selectively trapped by cancer cells through HA receptor-mediated endocytosis and subsequently release DOX due to Hyal-catalysed degradation of HA. This system presents successful bienzyme-responsive targeting drug delivery in an optimal fashion and provides potential applications for targeted cancer therapy.

scholarly journals Multifunctional Polymer Nanoparticles for Dual Drug Release and Cancer Cell Targeting

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 213 ◽  
Author(s):  
Yu-Han Wen ◽  
Tsung-Ying Lee ◽  
Ping-Chuan Fu ◽  
Chun-Liang Lo ◽  
Yi-Ting Chiang
Keyword(s):  
Drug Release ◽  
Cancer Cell ◽  
Polymer Nanoparticles ◽  
Cell Targeting ◽  
Cancer Cell Targeting ◽  
Dual Drug

scholarly journals Frailty in Patients Undergoing Colorectal Cancer Treatment

2019 ◽  
Vol 33 (6) ◽  
pp. 551-552
Author(s):  
Mateusz Rubinkiewicz ◽  
Michał Pędziwiatr
Keyword(s):  
Colorectal Cancer ◽  
Cancer Treatment ◽  
Colorectal Cancer Treatment
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