scholarly journals Multifunctional Polymer Nanoparticles for Dual Drug Release and Cancer Cell Targeting

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 213 ◽  
Author(s):  
Yu-Han Wen ◽  
Tsung-Ying Lee ◽  
Ping-Chuan Fu ◽  
Chun-Liang Lo ◽  
Yi-Ting Chiang
Keyword(s):  
Drug Release ◽  
Cancer Cell ◽  
Polymer Nanoparticles ◽  
Cell Targeting ◽  
Cancer Cell Targeting ◽  
Dual Drug

Preparation and folic acid conjugation of fluorescent polymer nanoparticles for cancer cell targeting

2012 ◽  
Vol 22 (31) ◽  
pp. 16078 ◽  
Author(s):  
Xinxin Qiang ◽  
Tong Wu ◽  
Jiangli Fan ◽  
Jingyun Wang ◽  
Fengling Song ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cell ◽  
Polymer Nanoparticles ◽  
Cell Targeting ◽  
Fluorescent Polymer ◽  
Cancer Cell Targeting

β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery

2019 ◽  
Vol 206 ◽  
pp. 694-705 ◽  
Author(s):  
Manita Das ◽  
Archana Solanki ◽  
Apeksha Joshi ◽  
Ranjitsinh Devkar ◽  
Sriram Seshadri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Cell Targeting ◽  
Dual Responsive ◽  
Cancer Cell Targeting ◽  
Dual Drug

scholarly journals An oxaliplatin(iv) prodrug-based supramolecular self-delivery nanocarrier for targeted colorectal cancer treatment

2018 ◽  
Vol 54 (90) ◽  
pp. 12762-12765 ◽  
Author(s):  
Wei Qi Lim ◽  
Soo Zeng Fiona Phua ◽  
Hongzhong Chen ◽  
Yanli Zhao
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cell Targeting ◽  
Redox Responsive ◽  
Two Component ◽  
Cancer Cell Targeting ◽  
Colorectal Cancer Treatment

A two-component supramolecular prodrug nanocarrier fabricated via self-assembly presents redox-responsive drug release with cancer cell-targeting capability, showing enhanced efficiency for colorectal cancer treatment.

scholarly journals Mesoporous silica nanoparticle-based intelligent drug delivery system for bienzyme-responsive tumour targeting and controlled release

2018 ◽  
Vol 5 (1) ◽  
pp. 170986 ◽  
Author(s):  
Yang Zhang ◽  
Juan Xu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cell ◽  
Silica Nanoparticle ◽  
Cell Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Cancer Cell Targeting

This paper proposes a novel type of multifunctional envelope-type mesoporous silica nanoparticle (MSN) to achieve cancer cell targeting and drug-controlled release. In this system, MSNs were first modified by active targeting moiety hyaluronic acid (HA) for breast cancer cell targeting and hyaluronidases (Hyal)-induced intracellular drug release. Then gelatin, a proteinaceous biopolymer, was grafted onto the MSNs to form a capping layer via glutaraldehyde-mediated cross-linking. To shield against unspecific uptake of cells and prolong circulation time, the nanoparticles were further decorated with poly(ethylene glycol) polymers (PEG) to obtain MSN@HA-gelatin-PEG (MHGP). Doxorubicin (DOX), as a model drug, was loaded into PEMSN to assess the breast cancer cell targeting and drug release behaviours. In vitro study revealed that PEG chains protect the targeting ligand and shield against normal cells. After reaching the breast cancer cells, MMP-2 overpressed by cells hydrolyses gelatin layer to deshield PEG and switch on the function of HA. As a result, DOX-loaded MHGP was selectively trapped by cancer cells through HA receptor-mediated endocytosis and subsequently release DOX due to Hyal-catalysed degradation of HA. This system presents successful bienzyme-responsive targeting drug delivery in an optimal fashion and provides potential applications for targeted cancer therapy.

scholarly journals Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

RSC Advances ◽  
2021 ◽  
Vol 11 (26) ◽  
pp. 16131-16141
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Siti Nadiah Zulkifli ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Chemotherapeutic Agent ◽  
Cell Targeting ◽  
Specific Targeting ◽  
Colorectal Cancer Cells ◽  
Cancer Cell Targeting

5-FU-PEGylated AuNPs-CD133 is designed to improve specific targeting of 5-FU against colorectal cancer cells which abundantly express CD133.

⿿Blind⿿ targeting in action: From phage display to breast cancer cell targeting with peptide-gold nanoconjugates

2016 ◽  
Vol 111 ◽  
pp. 155-162 ◽  
Author(s):  
Elisabetta Galbiati ◽  
Luca Gambini ◽  
Viola Civitarese ◽  
Michela Bellini ◽  
Dario Ambrosini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Phage Display ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Targeting ◽  
Cancer Cell Targeting

Phosphatidylserine: A cancer cell targeting biomarker

2018 ◽  
Vol 52 ◽  
pp. 17-25 ◽  
Author(s):  
Bhupender Sharma ◽  
Shamsher S. Kanwar
Keyword(s):  
Cancer Cell ◽  
Cell Targeting ◽  
Cancer Cell Targeting

scholarly journals Gold-Coated Fe3O4Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging, and Therapy

2013 ◽  
Vol 24 (12) ◽  
pp. 1772-1780 ◽  
Author(s):  
Chunmei Li ◽  
Tao Chen ◽  
Ismail Ocsoy ◽  
Guizhi Zhu ◽  
Emir Yasun ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Targeting ◽  
Cancer Cell Targeting

Nanoparticle–Aptamer Conjugates for Cancer Cell Targeting and Detection

2010 ◽  
pp. 235-248 ◽  
Author(s):  
M. Carmen Estévez ◽  
Yu-Fen Huang ◽  
Huaizhi Kang ◽  
Meghan B. O’Donoghue ◽  
Suwussa Bamrungsap ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Targeting ◽  
Cancer Cell Targeting

Tracking Hyaluronan: Molecularly Imprinted Polymer Coated Carbon Dots for Cancer Cell Targeting and Imaging

2018 ◽  
Vol 10 (4) ◽  
pp. 3305-3313 ◽  
Author(s):  
Bilal Demir ◽  
Michael M. Lemberger ◽  
Maria Panagiotopoulou ◽  
Paulina X. Medina Rangel ◽  
Suna Timur ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Molecularly Imprinted Polymer ◽  
Carbon Dots ◽  
Cell Targeting ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cancer Cell Targeting ◽  
Coated Carbon
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