Bicyclic and tricyclic C–C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs

2018 ◽  
Vol 54 (51) ◽  
pp. 7074-7077 ◽  
Author(s):  
Tomonori Shibata ◽  
Kazuhiko Nakatani
Keyword(s):  
Structural Change ◽  
Aromatic Ring ◽  
Trinucleotide Repeat ◽  
Ring System ◽  
Trinucleotide Repeats ◽  
System P ◽  
Bivalent Interaction

A structural change-inducible ligand that binds to CCG trinucleotide repeats was developed via bivalent interaction and enlarging the aromatic ring system.

Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle

2017 ◽  
Vol 53 (54) ◽  
pp. 7447-7450 ◽  
Author(s):  
Hidetoshi Noda ◽  
Yasuko Asada ◽  
Masakatsu Shibasaki ◽  
Naoya Kumagai
Keyword(s):  
Carboxylic Acids ◽  
Ring System ◽  
System P

Dehydrative coupling of sulfoximines and carboxylic acids is rendered catalytic by a heterocyclic catalyst featuring the B3NO2 ring system.

Synthesis, computational, and spectroscopic analysis of tunable highly fluorescent BN-1,2-azaborine derivatives containing the N-BOH moiety

2017 ◽  
Vol 15 (48) ◽  
pp. 10172-10183 ◽  
Author(s):  
Carl Jacky Saint-Louis ◽  
Renée N. Shavnore ◽  
Caleb D. C. McClinton ◽  
Julie A. Wilson ◽  
Lacey L. Magill ◽  
...  
Keyword(s):  
Electron Donor ◽  
Spectroscopic Analysis ◽  
Ring System ◽  
Quantum Yields ◽  
System P ◽  
Donor And Acceptor ◽  
Electron Donor And Acceptor

Methods to tune the luminescence wavelength and the quantum yields by controlling the power and location of electron-donor and acceptor substituents on the ring system.

scholarly journals Trimerisation of carbon suboxide at a di-titanium centre to form a pyrone ring system

2018 ◽  
Vol 9 (22) ◽  
pp. 5008-5014 ◽  
Author(s):  
Nikolaos Tsoureas ◽  
Jennifer C. Green ◽  
F. Geoffrey N. Cloke ◽  
Horst Puschmann ◽  
S. Mark Roe ◽  
...  
Keyword(s):  
Ring System ◽  
Carbon Suboxide ◽  
Pyrone Ring ◽  
System P

Bis(pentalene)dititanium Ti2(μ:η5,η5-Pn†)2 trimerises carbon suboxide (OCCCO) to form [{Ti2(μ:η5,η5-Pn†)2}{μ-C9O6}], which contains a 4-pyrone core, via the monoadduct [Ti2(μ:η5,η5-Pn†)2 (η2-C3O2)].

Carbon quantum dots derived by direct carbonization of carbonaceous microcrystals in mesophase pitch

Nanoscale ◽  
2018 ◽  
Vol 10 (45) ◽  
pp. 21492-21498 ◽  
Author(s):  
Haibin Wang ◽  
Guoqing Ning ◽  
Xing He ◽  
Xinlong Ma ◽  
Fan Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Aromatic Ring ◽  
Carbon Quantum Dots ◽  
Ring System ◽  
Mesophase Pitch

Aggregation of the central aromatic ring system of asphaltene molecules due to π–π interaction can lead to the formation of carbon quantum dots (CQDs).

scholarly journals Microsatellite and trinucleotide-repeat evolution: evidence for mutational bias and different rates of evolution in different lineages

1999 ◽  
Vol 354 (1386) ◽  
pp. 1095-1099 ◽  
Author(s):  
David C. Rubinsztein ◽  
Bill Amos ◽  
Gillian Cooper
Keyword(s):  
Repetitive Dna ◽  
Empirical Data ◽  
Population Genetic ◽  
Trinucleotide Repeat ◽  
Trinucleotide Repeats ◽  
Mutational Bias ◽  
Repeat Number ◽  
Repeat Units ◽  
Rates Of Evolution ◽  
Disease Loci

Microsatellites are stretches of repetitive DNA, where individual repeat units comprise one to six bases. These sequences are often highly polymorphic with respect to repeat number and include trinucleotide repeats, which are abnormally expanded in a number of diseases. It has been widely assumed that microsatellite loci are as likely to gain and lose repeats when they mutate. In this review, we present population genetic and empirical data arguing that microsatellites, including normal alleles at trinucleotide repeat disease loci, are more likely to expand in length when they mutate. In addition, our experiments suggest that the rates of expansion of such sequences differ in related species.

Practical synthesis and cytotoxic evaluation of the pyrazino[1,2-b]-isoquinoline ring system

2016 ◽  
Vol 14 (21) ◽  
pp. 4875-4884 ◽  
Author(s):  
Eduardo Hernández-Vázquez ◽  
Luis D. Miranda
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Ring System ◽  
System P ◽  
Practical Synthesis

A multicomponent three-step synthesis of pyrazino[1-2b]isoquinolines is described. A preliminary cytotoxic screening against cancer cell lines was performed.

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