Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle

2017 ◽  
Vol 53 (54) ◽  
pp. 7447-7450 ◽  
Author(s):  
Hidetoshi Noda ◽  
Yasuko Asada ◽  
Masakatsu Shibasaki ◽  
Naoya Kumagai
Keyword(s):  
Carboxylic Acids ◽  
Ring System ◽  
System P

Dehydrative coupling of sulfoximines and carboxylic acids is rendered catalytic by a heterocyclic catalyst featuring the B3NO2 ring system.

Metal free decarboxylative aminoxylation of carboxylic acids using a biphasic solvent system

2021 ◽  
Vol 19 (1) ◽  
pp. 273-278
Author(s):  
Göran Schulz ◽  
Andreas Kirschning
Keyword(s):  
Carboxylic Acids ◽  
Solvent System ◽  
Radical Scavenger ◽  
Synthetic Approach ◽  
Metal Free ◽  
System P

The oxidative radical decarboxylation of carboxylic acids with TEMPO as radical scavenger in a biphasic solvent system is reported which is successfully used in a new synthetic approach for the antidepressants indatraline.

Synthesis, computational, and spectroscopic analysis of tunable highly fluorescent BN-1,2-azaborine derivatives containing the N-BOH moiety

2017 ◽  
Vol 15 (48) ◽  
pp. 10172-10183 ◽  
Author(s):  
Carl Jacky Saint-Louis ◽  
Renée N. Shavnore ◽  
Caleb D. C. McClinton ◽  
Julie A. Wilson ◽  
Lacey L. Magill ◽  
...  
Keyword(s):  
Electron Donor ◽  
Spectroscopic Analysis ◽  
Ring System ◽  
Quantum Yields ◽  
System P ◽  
Donor And Acceptor ◽  
Electron Donor And Acceptor

Methods to tune the luminescence wavelength and the quantum yields by controlling the power and location of electron-donor and acceptor substituents on the ring system.

scholarly journals Trimerisation of carbon suboxide at a di-titanium centre to form a pyrone ring system

2018 ◽  
Vol 9 (22) ◽  
pp. 5008-5014 ◽  
Author(s):  
Nikolaos Tsoureas ◽  
Jennifer C. Green ◽  
F. Geoffrey N. Cloke ◽  
Horst Puschmann ◽  
S. Mark Roe ◽  
...  
Keyword(s):  
Ring System ◽  
Carbon Suboxide ◽  
Pyrone Ring ◽  
System P

Bis(pentalene)dititanium Ti2(μ:η5,η5-Pn†)2 trimerises carbon suboxide (OCCCO) to form [{Ti2(μ:η5,η5-Pn†)2}{μ-C9O6}], which contains a 4-pyrone core, via the monoadduct [Ti2(μ:η5,η5-Pn†)2 (η2-C3O2)].

Practical synthesis and cytotoxic evaluation of the pyrazino[1,2-b]-isoquinoline ring system

2016 ◽  
Vol 14 (21) ◽  
pp. 4875-4884 ◽  
Author(s):  
Eduardo Hernández-Vázquez ◽  
Luis D. Miranda
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Ring System ◽  
System P ◽  
Practical Synthesis

A multicomponent three-step synthesis of pyrazino[1-2b]isoquinolines is described. A preliminary cytotoxic screening against cancer cell lines was performed.

A missing member of conjugated N-heterocycles: realizing pyrido[1,2-α]azepine by reacting ruthenium alkenylcarbene complex with alkyne

2018 ◽  
Vol 54 (32) ◽  
pp. 4009-4012 ◽  
Author(s):  
Xiaoxi Zhou ◽  
Fanping Huang ◽  
Chun Tang ◽  
Qingde Zhuo ◽  
Zhixin Chen ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Ring System ◽  
Synthesis And Characterization ◽  
System P

The first successful chemical synthesis and characterization of a bicyclic pyrido[1,2-α]azepine ring system.

scholarly journals Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

2010 ◽  
Vol 7 (1) ◽  
pp. 222-226 ◽  
Author(s):  
B. Anil Reddy
Keyword(s):  
Spectral Data ◽  
Carboxylic Acids ◽  
Benzene Ring ◽  
Mannich Base ◽  
Mannich Bases ◽  
Biological Evaluation ◽  
Ring System ◽  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
Benzimidazole Ring

The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti-inflammatory activity. The various positions on the benzimidazole ring are numbered in the manner indicated with the imino function as number one. The formations of the product were conformed by the analytical and spectral data.

A new approach to the 8b-azaacenaphthylene ring system

2015 ◽  
Vol 13 (38) ◽  
pp. 9834-9843 ◽  
Author(s):  
Anushree Kamath ◽  
Charles-Henry Fabritius ◽  
Christian Philouze ◽  
Philippe Delair
Keyword(s):  
Ring System ◽  
New Approach ◽  
System P

A new approach to the 8b-azaacenaphthylene ring system is described featuring several stereoselective transformations.

Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

2019 ◽  
Vol 6 (5) ◽  
pp. 591-596 ◽  
Author(s):  
Hongxin Liu ◽  
Haibo Tan ◽  
Wenxuan Wang ◽  
Wenge Zhang ◽  
Yuchan Chen ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Ring System ◽  
System P ◽  
Fused Ring ◽  
Fused Ring System

(±)-Cytorhizophin A and cytorhizophin B (2), novel benzophenone-hemiterpene conjugated hetero-dimers featuring an unprecedented 6/7/6/7 tetracyclic fused ring system.

pKa values of protonated α,β-unsaturated cyclic carboxylic acids. Effect of ring size on acidities

1978 ◽  
Vol 56 (15) ◽  
pp. 2003-2007 ◽  
Author(s):  
S. N. Bhat ◽  
Rama Rao ◽  
K. Ranganayakulu
Keyword(s):  
Double Bond ◽  
Carboxylic Acids ◽  
Acid Strength ◽  
Ring System ◽  
Ring Size ◽  
Methyl Group ◽  
Tiglic Acid ◽  
Conjugate Acid ◽  
The Difference ◽  
Steric Inhibition Of Resonance

The pKa values of protonated α,β-unsaturated acids, namely tiglic, cyclopentene carboxylic, cyclohexene carboxylic, and cycloheptene carboxylic acids have been determined spectrophotometrically and the values are −4.08, −4.05, −3.88, and −3.84, respectively. The conjugate acid of tiglic acid is a stronger acid than that of crotonic acid (pKa − 3.94) and the difference in acid strength is explained on the basis of steric inhibition of resonance by the α-methyl group. All the protonated cyclic acids are shown to be somewhat weaker than the corresponding acyclic ones. Several factors have been considered to explain the acid strength of these cyclic α,β-unsaturated acids. It has been shown that the ease of placing the double bond exo to the ring system is responsible for the changes in acidity of the above cyclic systems.

Bioactive 18(4 → 3)-abeo-abietanoid derivatives from the leaves of Tripterygium wilfordii

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 30046-30052 ◽  
Author(s):  
Chao Wang ◽  
Chuang-Jun Li ◽  
Jie Ma ◽  
Jing-Zhi Yang ◽  
Xiao-Guang Chen ◽  
...  
Keyword(s):  
Ring System ◽  
Tripterygium Wilfordii ◽  
System P

Tripterlides A–F are new abietane derivatives, obtained from Tripterygium wilfordii. 1–4 are novel 14(13 → 12),18(4 → 3)-diabeo-abietanoids possessing a 6/6/5 tricyclic ring system.

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