IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer

2018 ◽  
Vol 6 (11) ◽  
pp. 2925-2931 ◽  
Author(s):  
Kaizong Huang ◽  
Mengyue Gao ◽  
Lin Fan ◽  
Yueyang Lai ◽  
Hongwei Fan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Photothermal Therapy ◽  
Aqueous Environment ◽  
Zinc Ions ◽  
Tumor Site ◽  
Self Assembled ◽  
Covalently Linked

Elastin-like polypeptide covalently was linked with IR820 in an aqueous environment, followed by self-assembly into nanoparticles after adding to zinc ions solution. ELP-IR820 nanoparticles significantly accumulated at the tumor site.

scholarly journals Artificial flexible sperm-like nanorobot based on self-assembly and its bidirectional propulsion in precessing magnetic fields

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nuoer Celi ◽  
De Gong ◽  
Jun Cai
Keyword(s):  
Magnetic Fields ◽  
Self Assembly ◽  
High Speed ◽  
Biomedical Application ◽  
Tail Length ◽  
The Body ◽  
High Yield ◽  
Bending Waves ◽  
Self Assembled ◽  
Covalently Linked

AbstractSperm cells can move at a high speed in biofluids based on the flexible flagella, which inspire novel flagellar micro-/nanorobots to be designed. Despite progress in fabricating sperm-type robots at micro scale, mass fabrication of vivid sperm-like nanorobots with flagellar flexibility is still challenging. In this work, a facile and efficient strategy is proposed to produce flexible sperm-like nanorobots with self-assembled head-to-tail structure, and its bidirectional propulsion property was studied in detail. The nanorobots were composed of a superparamagnetic head and a flexible Au/PPy flagellum, which were covalently linked via biotin-streptavidin bonding with a high yield. Under precessing magnetic fields, the head drove the flexible tail to rotate and generated undulatory bending waves propagating along the body. Bidirectional locomotion was investigated, and moving velocity as well as direction varied with the actuating conditions (field strength, frequency, direction) and the nanorobot’s structure (tail length). Effective flagellar propulsion was observed near the substrate and high velocities were attained to move back and forth without U-turn. Typical modelling based on elastohydrodynamics and undulatory wave propagation were utilized for propulsion analysis. This research presents novel artificial flexible sperm-like nanorobots with delicate self-assembled head-to-tail structures and remarkable bidirectional locomotion performances, indicating significant potentials for nanorobotic design and future biomedical application.

scholarly journals Self-assembled Nanoparticles of Polycationic b Rush and p Hotosensitizer for Synergistic Photothermal and Photodynamic Therapies Against Periodontitis

2021 ◽  
Author(s):  
Enyu Shi ◽  
Liya Bai ◽  
Lujia Mao ◽  
Hanping Wang ◽  
Xiaoying Yang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Photothermal Therapy ◽  
Chronic Inflammatory Disease ◽  
Bacterial Cells ◽  
Antibacterial Effects ◽  
Self Assembled ◽  
Bacterial Cell Membrane ◽  
Pass Through

Abstract Background: Periodontitis is a chronic inflammatory disease in oral cavity owing to bacterial infection. Photothermal therapy (PTT) and photodynamic therapy (PDT) have many advantages for antibacterial treatment. As an excellent photosensitizer, indocyanine green (ICG) shows prominent photothermal and photodynamic performances. However, it is difficult to pass through the negatively charged bacterial cell membrane, thus limits its antibacterial efficacy for periodontitis treatment.Results: In this work, we developed a nanosystem from self-assembly of ICG and polycationic brush for synergistic PTT and PDT against periodontitis. A star-shaped polycationic brush, poly(2-(dimethylamino)ethyl methacrylate) (sPDMA), was synthesized via atom transfer radical polymerization (ATRP) of DMA monomer from bromo-substituted β-cyclodextrin initiator (CD-Br). ICG was then self-assembled with sPDMA to form ICG-loaded sPDMA (sPDMA@ICG) nanoparticles (NPs), and the physicochemical properties of these NPs were characterized in detail. In vitro antibacterial effects of sPDMA@ICG NPs were evaluated in porphyromonas gingivalis (Pg), one of the recognized periodontitis pathogens, and in vivo anti-periodontitis effects of NPs were investigated in a rat periodontitis model. Benefiting from the unique brush-shaped architecture of sPDMA polycation, sPDMA@ICG NPs efficiently delivered ICG into the bacterial cells through promoting their adsorption and penetration abilities, and also exhibited effective antibacterial and anti-periodontitis actions via synergistic PTT and PDT both in vitro and in vivo.Conclusions: This work developed a promising nano-photosensitizer for synergistic PTT and PDT for antibacterial and periodontitis treatments in clinic.

scholarly journals Correction: IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer

2018 ◽  
Vol 6 (12) ◽  
pp. 3410-3410
Author(s):  
Kaizong Huang ◽  
Mengyue Gao ◽  
Lin Fan ◽  
Yueyang Lai ◽  
Hongwei Fan ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Self Assembled ◽  
Covalently Linked

Correction for ‘IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer’ by Kaizong Huang et al., Biomater. Sci., 2018, 6, 2925–2931.

scholarly journals A feasible strategy for self-assembly of gold nanoparticlesviadithiol-PEG for photothermal therapy of cancers

RSC Advances ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 6120-6124 ◽  
Author(s):  
Yingjie Fu ◽  
Qishuai Feng ◽  
Yajing Shen ◽  
Mengwei Chen ◽  
Chang Xu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Self Assembly ◽  
Photothermal Therapy ◽  
Cross Linking ◽  
Self Assembled

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking.

Pyrazine-based donor tectons: synthesis, self-assembly and characterization

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8992-9001 ◽  
Author(s):  
Sourav Bhowmick ◽  
Sourav Chakraborty ◽  
Subba R. Marri ◽  
J. N. Behera ◽  
Neeladri Das
Keyword(s):  
Self Assembly ◽  
Self Assembled ◽  
Covalently Linked

Two donor tectons, each bearing a central pyrazine moiety covalently linked to two pyridine units, have been self-assembled with PtII2 acceptor units to yield ionic nanoscalar metallamacrocycles, having a convex hexagonal cavity.

scholarly journals Artificial Flexible Sperm-like Nanorobot Based on Self-assembly and Its Magnetically Actuated Propulsion Property

2021 ◽  
Author(s):  
Nuoer Celi ◽  
De Gong ◽  
Jun Cai
Keyword(s):  
Self Assembly ◽  
High Speed ◽  
Biomedical Application ◽  
Tail Length ◽  
The Body ◽  
Bending Waves ◽  
Magnetically Actuated ◽  
Tail Structure ◽  
Self Assembled ◽  
Covalently Linked

Abstract Sperm cells can move at a high speed in biofluids based on the flexible flagella, which inspire novel flagellar micro-/nanorobots to be designed. However, mass fabrication of vivid sperm-like nanorobots with flagellar flexibility is still challenging. In this work, a facile and efficient strategy is proposed to produce flexible sperm-like nanorobots with self-assembled head-to-tail structure. The nanorobots were composed of a superparamagnetic head and a flexible Au/PPy flagellum, which were covalently linked via biotin-streptavidin bonding. Under a precessing magnetic field, the head drove the flexible tail to rotate and generated undulatory bending waves propagating along the body. Bidirectional locomotion of the nanorobot was investigated, and moving velocity as well as direction varied with the actuating conditions (field strength, frequency, direction) and the nanorobot’s structure (tail length). Effective flagellar locomotion was observed near the substrate and high velocities were attained in both forward and backward directions. Typical modelling based on elastohydrodynamics and undulatory wave propagation were utilized for propulsion analysis. This research presents novel artificial flexible sperm-like nanorobots with delicate self-assembled head-to-tail structures and remarkable bidirectional locomotion performances, indicating significant potentials for nanorobotic design and future biomedical application.

Nanoscale Self-Assembly Using Ion and Electron Beam Techniques: A Rapid Review

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3507-3520
Author(s):  
Chunhui Dai ◽  
Kriti Agarwal ◽  
Jeong-Hyun Cho
Keyword(s):  
Electron Beam ◽  
Self Assembly ◽  
Ion Beam ◽  
Three Dimensional ◽  
The Self ◽  
Stress Generation ◽  
Rapid Review ◽  
High Yield ◽  
3D Nanostructures ◽  
Self Assembled

AbstractNanoscale self-assembly, as a technique to transform two-dimensional (2D) planar patterns into three-dimensional (3D) nanoscale architectures, has achieved tremendous success in the past decade. However, an assembly process at nanoscale is easily affected by small unavoidable variations in sample conditions and reaction environment, resulting in a low yield. Recently, in-situ monitored self-assembly based on ion and electron irradiation has stood out as a promising candidate to overcome this limitation. The usage of ion and electron beam allows stress generation and real-time observation simultaneously, which significantly enhances the controllability of self-assembly. This enables the realization of various complex 3D nanostructures with a high yield. The additional dimension of the self-assembled 3D nanostructures opens the possibility to explore novel properties that cannot be demonstrated in 2D planar patterns. Here, we present a rapid review on the recent achievements and challenges in nanoscale self-assembly using electron and ion beam techniques, followed by a discussion of the novel optical properties achieved in the self-assembled 3D nanostructures.

Self-Assembly of a Chiral Cubic Three-Connected Net from the High Symmetry Molecules C60 and SnI4

2020 ◽  
Author(s):  
Daniel B. Straus ◽  
Robert J. Cava
Keyword(s):  
Organic Synthesis ◽  
Self Assembly ◽  
Van Der Waals ◽  
Van Der Waals Forces ◽  
High Symmetry ◽  
Molecular Chirality ◽  
Chiral Materials ◽  
Self Assembled ◽  
Chiral Centers

The design of new chiral materials usually requires stereoselective organic synthesis to create molecules with chiral centers. Less commonly, achiral molecules can self-assemble into chiral materials, despite the absence of intrinsic molecular chirality. Here, we demonstrate the assembly of high-symmetry molecules into a chiral van der Waals structure by synthesizing crystals of C<sub>60</sub>(SnI<sub>4</sub>)<sub>2</sub> from icosahedral buckminsterfullerene (C<sub>60</sub>) and tetrahedral SnI4 molecules through spontaneous self-assembly. The SnI<sub>4</sub> tetrahedra template the Sn atoms into a chiral cubic three-connected net of the SrSi<sub>2</sub> type that is held together by van der Waals forces. Our results represent the remarkable emergence of a self-assembled chiral material from two of the most highly symmetric molecules, demonstrating that almost any molecular, nanocrystalline, or engineered precursor can be considered when designing chiral assemblies.

scholarly journals Nano- and Micropatterning on Optical Fibers by Bottom-Up Approach: The Importance of Being Ordered

2021 ◽  
Vol 11 (7) ◽  
pp. 3254
Author(s):  
Marco Pisco ◽  
Francesco Galeotti
Keyword(s):  
Optical Fiber ◽  
Optical Fibers ◽  
Self Assembly ◽  
Ordered Structures ◽  
Bottom Up ◽  
Photonic Structures ◽  
Fiber Technology ◽  
Optical Fiber Probes ◽  
Fiber Probes ◽  
Self Assembled

The realization of advanced optical fiber probes demands the integration of materials and structures on optical fibers with micro- and nanoscale definition. Although researchers often choose complex nanofabrication tools to implement their designs, the migration from proof-of-principle devices to mass production lab-on-fiber devices requires the development of sustainable and reliable technology for cost-effective production. To make it possible, continuous efforts are devoted to applying bottom-up nanofabrication based on self-assembly to decorate the optical fiber with highly ordered photonic structures. The main challenges still pertain to “order” attainment and the limited number of implementable geometries. In this review, we try to shed light on the importance of self-assembled ordered patterns for lab-on-fiber technology. After a brief presentation of the light manipulation possibilities concerned with ordered structures, and of the new prospects offered by aperiodically ordered structures, we briefly recall how the bottom-up approach can be applied to create ordered patterns on the optical fiber. Then, we present un-attempted methodologies, which can enlarge the set of achievable structures, and can potentially improve the yielding rate in finely ordered self-assembled optical fiber probes by eliminating undesired defects and increasing the order by post-processing treatments. Finally, we discuss the available tools to quantify the degree of order in the obtained photonic structures, by suggesting the use of key performance figures of merit in order to systematically evaluate to what extent the pattern is really “ordered”. We hope such a collection of articles and discussion herein could inspire new directions and hint at best practices to fully exploit the benefits inherent to self-organization phenomena leading to ordered systems.

scholarly journals Self-assembled interpenetrating networks by orthogonal self assembly of surfactants and hydrogelators

2009 ◽  
Vol 143 ◽  
pp. 345 ◽  
Author(s):  
Aurelie M. Brizard ◽  
Marc C. A. Stuart ◽  
Jan H. van Esch
Keyword(s):  
Self Assembly ◽  
Interpenetrating Networks ◽  
Self Assembled
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