Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment

2018 ◽  
Vol 6 (6) ◽  
pp. 1414-1423 ◽  
Author(s):  
Peng Pei ◽  
Fan Yang ◽  
Jiaxing Liu ◽  
Haoran Hu ◽  
Xiaoyu Du ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Photothermal Therapy ◽  
Casting Process ◽  
Doxorubicin Hydrochloride ◽  
Tumor Treatment ◽  
Promising Strategy ◽  
Superficial Tumor

Doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) were successfully fabricated using a two-step casting process, which is a promising strategy for synergistic therapy of superficial tumors.

scholarly journals Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Matias Luis Picchio ◽  
Julian Bergueiro Álvarez ◽  
Stefanie Wedepohl ◽  
Roque J Minari ◽  
Cecilia Ines Alvarez Igarzabal ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Hydrophobic Protein ◽  
Nir Dyes ◽  
Protein Pockets ◽  
J Aggregates ◽  
Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

Real-time MRI-controlled ultrasound hyperthermia system for superficial tumor treatment

2014 ◽  
Vol 19 (6) ◽  
pp. 715-717 ◽  
Author(s):  
Meng-yuan Zhu ◽  
Guo-feng Shen ◽  
Zhi-qiang Su ◽  
Sheng Chen ◽  
Hao Wu
Keyword(s):  
Real Time ◽  
Tumor Treatment ◽  
Ultrasound Hyperthermia ◽  
Superficial Tumor

The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Treatment Outcome ◽  
Gene Silencing ◽  
Large Volume ◽  
Photothermal Therapy ◽  
Tumor Model ◽  
Vascular Wall ◽  
Tumor Treatment ◽  
Physical Methods ◽  
Vascular Disruption ◽  
Tumor Neovascularization

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.

Bubble-generating polymersomes loaded with both indocyanine green and doxorubicin for effective chemotherapy combined with photothermal therapy

2018 ◽  
Vol 75 ◽  
pp. 386-397 ◽  
Author(s):  
Dunwan Zhu ◽  
Fan Fan ◽  
Chenlu Huang ◽  
Zhiming Zhang ◽  
Yu Qin ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Photothermal Therapy

Leveraging BODIPY nanomaterials for enhanced tumor photothermal therapy

2021 ◽  
Author(s):  
Chong Ma ◽  
Tao Zhang ◽  
Zhigang Xie
Keyword(s):  
Side Effects ◽  
Photothermal Therapy ◽  
Tumor Treatment ◽  
The Past

In the past ten years, photothermal therapy (PTT) has attracted widespread attention in tumor treatment due to its non-invasiveness and little side effects. PTT utilize the heat produced by photothermal...

Photothermal Therapy Combined with Light-Induced Generation of Alkyl Radicals for Enhanced Efficacy of Tumor Treatment

2020 ◽  
Vol 2 (10) ◽  
pp. 4188-4194
Author(s):  
Qihang Wu ◽  
Jinfeng Han ◽  
Chaonan Li ◽  
Tingting Sun ◽  
Zhigang Xie
Keyword(s):  
Photothermal Therapy ◽  
Tumor Treatment ◽  
Alkyl Radicals

scholarly journals Research on Targeted Thermal Effect of Molybdenum Disulfide Nanosheets Modified by Nucleic Acid Aptamers

2020 ◽  
Vol 185 ◽  
pp. 04003
Author(s):  
Bo pang ◽  
Lihong Jin ◽  
Liying Wang
Keyword(s):  
Nucleic Acid ◽  
Molybdenum Disulfide ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Effective Concentration ◽  
Tumor Treatment ◽  
Nucleic Acid Aptamers ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Molybdenum Disulfide Nanosheets

In this paper, the surface of molybdenum disulfide nanosheets synthesized by hydrothermal method was modified with bovine serum albumin (BSA) and nucleic acid aptamers in order to construct a photothermal system with high target recognition, stable size, good biocompatibility and low toxicity Nano material molybdenum disulfide; Under 808 nm laser irradiation, suitable functionalized molybdenum disulfide nanosheets can produce singlet oxygen at an effective concentration for photodynamic therapy, and at the same time, photothermal therapy can also be used to achieve synergistic therapy and the therapeutic effect is more excellent. This shows that such functionalized molybdenum disulfide nanosheets have excellent therapeutic effect and great potential in tumor treatment.

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