Rapid screening of antimalarial drugs using low-temperature plasma desorption/ionization Orbitrap mass spectrometry

2019 ◽  
Vol 11 (5) ◽  
pp. 566-574 ◽  
Author(s):  
Derick N. Ateacha ◽  
Christopher Kuhlmann ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Third World ◽  
Antimalarial Drugs ◽  
Rapid Screening ◽  
Low Temperature Plasma ◽  
Counterfeit Drugs ◽  
Temperature Plasma ◽  
Desorption Ionization ◽  
Plasma Desorption ◽  
Orbitrap Mass Spectrometry

Antimalarial drugs for the treatment of malaria are amongst the most counterfeit drugs in third world countries.

Rapid and quantitative analysis of pesticides in fruits by QuEChERS pretreatment and low-temperature plasma desorption/ionization orbitrap mass spectrometry

2014 ◽  
Vol 6 (15) ◽  
pp. 5463-5471 ◽  
Author(s):  
Anastasia Albert ◽  
Andrea Kramer ◽  
Simon Scheeren ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Low Temperature ◽  
High Resolution Mass Spectrometry ◽  
Low Temperature Plasma ◽  
Temperature Plasma ◽  
Real Samples ◽  
Desorption Ionization ◽  
Plasma Desorption ◽  
Orbitrap Mass Spectrometry

Low-temperature plasma ambient desorption/ionization high-resolution mass spectrometry is validated for quantitative analysis of pesticides in real samples.

scholarly journals Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andreas Kiontke ◽  
Mehrzad Roudini ◽  
Susan Billig ◽  
Amarghan Fakhfouri ◽  
Andreas Winkler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Low Temperature ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Ionization Mechanism ◽  
Low Temperature Plasma ◽  
Ambient Conditions ◽  
Temperature Plasma ◽  
Plasma Ionization ◽  
Surface Acoustic Wave Nebulization

AbstractMass spectrometry coupled to low-temperature plasma ionization (LTPI) allows for immediate and easy analysis of compounds from the surface of a sample at ambient conditions. The efficiency of this process, however, strongly depends on the successful desorption of the analyte from the surface to the gas phase. Whilst conventional sample heating can improve analyte desorption, heating is not desirable with respect to the stability of thermally labile analytes. In this study using aromatic amines as model compounds, we demonstrate that (1) surface acoustic wave nebulization (SAWN) can significantly improve compound desorption for LTPI without heating the sample. Furthermore, (2) SAWN-assisted LTPI shows a response enhancement up to a factor of 8 for polar compounds such as aminophenols and phenylenediamines suggesting a paradigm shift in the ionization mechanism. Additional assets of the new technique demonstrated here are (3) a reduced analyte selectivity (the interquartile range of the response decreased by a factor of 7)—a significant benefit in non-targeted analysis of complex samples—and (4) the possibility for automated online monitoring using an autosampler. Finally, (5) the small size of the microfluidic SAWN-chip enables the implementation of the method into miniaturized, mobile LTPI probes.

scholarly journals Author Correction: Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andreas Kiontke ◽  
Mehrzad Roudini ◽  
Susan Billig ◽  
Armaghan Fakhfouri ◽  
Andreas Winkler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Low Temperature ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Low Temperature Plasma ◽  
Temperature Plasma ◽  
Plasma Ionization ◽  
Surface Acoustic Wave Nebulization

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Automated chemical fingerprinting of Mexican spirits derived from Agave (tequila and mezcal) using direct-injection electrospray ionisation (DIESI) and low-temperature plasma (LTP) mass spectrometry

2017 ◽  
Vol 9 (34) ◽  
pp. 5023-5028 ◽  
Author(s):  
Sandra Martínez-Jarquín ◽  
Abigail Moreno-Pedraza ◽  
Daniel Cázarez-García ◽  
Robert Winkler
Keyword(s):  
Mass Spectrometry ◽  
Low Temperature ◽  
Direct Injection ◽  
Low Temperature Plasma ◽  
Temperature Plasma ◽  
Electrospray Ionisation ◽  
Chemical Fingerprinting

Tequila and mezcal are Mexican spirits prepared fromAgaveplants.

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