Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (24) ◽  
pp. 6069-6078 ◽  
Author(s):  
H. K. Yosef ◽  
T. Frick ◽  
M. K. Hammoud ◽  
A. Maghnouj ◽  
S. Hahn ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Raman Microscopy ◽  
Label Free ◽  
Colon Cancer Cells

This study demonstrates the efficacy and distribution of sorafenib in colon cancer cells by label-free Raman microscopy.

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

The Analyst ◽  
2014 ◽  
Vol 139 (5) ◽  
pp. 1155 ◽  
Author(s):  
Samir F. El-Mashtoly ◽  
Dennis Petersen ◽  
Hesham K. Yosef ◽  
Axel Mosig ◽  
Anke Reinacher-Schick ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Drug Distribution ◽  
Raman Microscopy ◽  
Label Free ◽  
Colon Cancer Cells

scholarly journals Anti-ROR1 functionalised PLGA nanoparticles modulate metastatic and EMT biomarkers via cellular uptake of curcumin and ICA in colon cancer cells SW480

2020 ◽  
Author(s):  
Shamim Sufi ◽  
Muddasarul Hoda ◽  
Sankar Pajaniradje ◽  
Victor Mukherjee ◽  
Sultana Parveen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Isothermal Calorimetry ◽  
Cell Surface Receptor ◽  
In Vivo Studies ◽  
Active Targeting ◽  
Colon Cancer Cells ◽  
Mesenchymal Transition ◽  
Surface Functionalisation

The challenge of next-generation nanoparticles (NPs) includes limited cellular uptake and loss by phagocytosis. General surface modification of NPs potentially enhances evasion from phagocytosis. However, active targeting and enhanced cellular uptake of nanoparticles are possible by surface functionalisation with molecules that have selective affinity for cancer cells. ROR1 is a cell surface receptor that is over-expressed in cancer cells. Hence, its conjugate antibody could be a potential surface functionalisation molecule. In the current study, anti-ROR1 antibody has been covalently attached to nanoparticles’ surface, thereby imparting its active targeting potential. Physicochemical and in vitro characterisations of the antibody-conjugated nanoparticles were performed. Surface functionalisation of nanoparticles was confirmed by scanning electron microscopy, isothermal calorimetry, and elemental analysis. Additionally, biomarkers of metastasis and epithelial-mesenchymal transition (EMT) were studied. Anti-ROR1 mAb tagged nanoparticles further confirmed therapeutic efficacy against colon cancer cells, SW480, thus, opening scope for further in vivo studies.

scholarly journals Role of pannexin-1 in the cellular uptake, release and hydrolysis of anandamide by T84 colon cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mireille Alhouayek ◽  
René Sorti ◽  
Jonathan D. Gilthorpe ◽  
Christopher J. Fowler
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Colon Cancer Cells ◽  
Pannexin 1 ◽  
Hydrolysis Of

Label-free distinction between p53+/+ and p53 -/- colon cancer cells using a graphene based SERS platform

2018 ◽  
Vol 118 ◽  
pp. 108-114 ◽  
Author(s):  
Owen Liang ◽  
Pu Wang ◽  
Ming Xia ◽  
Catherine Augello ◽  
Fan Yang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Label Free ◽  
Colon Cancer Cells

Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells

2017 ◽  
Vol 32 (6) ◽  
pp. 301-310 ◽  
Author(s):  
Kumiko Ueda ◽  
Ayasa Masuda ◽  
Misaki Fukuda ◽  
Shota Tanaka ◽  
Mika Hosokawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Deoxycytidine Kinase ◽  
Colon Cancer Cells

Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles

2018 ◽  
Vol 173 ◽  
pp. 1-11 ◽  
Author(s):  
Stefania Raimondo ◽  
Laura Saieva ◽  
Marta Cristaldi ◽  
Francesca Monteleone ◽  
Simona Fontana ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Citrus Limon ◽  
Acetyl Coa Carboxylase ◽  
Label Free ◽  
Colon Cancer Cells ◽  
Proteomic Profiling ◽  
Acetyl Coa

A specific probe for Hg2+ to delineate even H+ in pure aqueous buffer/Hct116 colon cancer cells: Hg(ii)–η2-arene π-interaction and a TBET-based fluorescence response

2014 ◽  
Vol 50 (92) ◽  
pp. 14421-14424 ◽  
Author(s):  
Upendar Reddy G. ◽  
Vadde Ramu ◽  
Sovan Roy ◽  
Nandaraj Taye ◽  
Samit Chattopadhyay ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Ligand Design ◽  
Specific Probe ◽  
Colon Cancer Cells ◽  
Fluorescence Response ◽  
Aqueous Buffer

Ligand design that allows a Hg(ii)–η2-arene π-interaction as well as a TBET-based luminescence response to distinguish between the cellular uptake of Hg2+ and H+ in live Hct116 colon cancer cells.

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