scholarly journals The safety evaluation of food flavouring substances: the role of metabolic studies

2018 ◽  
Vol 7 (4) ◽  
pp. 618-646 ◽  
Author(s):  
Robert L. Smith ◽  
Samuel M. Cohen ◽  
Shoji Fukushima ◽  
Nigel J. Gooderham ◽  
Stephen S. Hecht ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Safety Evaluation ◽  
Metabolic Studies ◽  
Physiological Disposition

The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data.

Analysis of the Safety Factors of Municipal Road Undercrossing Existing Bridge Based on Fuzzy Analytic Hierarchy Process Methods

2021 ◽  
pp. 036119812110318
Author(s):  
Yonghong Yang ◽  
Yu Chen ◽  
Zude Tang
Keyword(s):  
Safety Assessment ◽  
Evaluation Method ◽  
Comprehensive Evaluation ◽  
Safety Evaluation ◽  
Safety Factors ◽  
Analytic Hierarchy ◽  
Road Engineering ◽  
Existing Bridges ◽  
Hierarchy Process ◽  
Engineering Projects

Increasing traffic volume and insufficient road lanes often require municipal roads to be reconstructed and expanded. Where a road passes under a bridge, the reconstruction and expansion project will inevitably have an impact on the bridge. To evaluate the safety impact of road engineering projects on bridges, this paper evaluates the safety of the roads and ancillary facilities of highway bridges involved in municipal road engineering projects. Based on a comprehensive analysis of the safety factors of municipal roads undercrossing existing bridges, a fuzzy comprehensive analytic hierarchy process (AHP) evaluation method for the influence of road construction on the safety of existing bridges is proposed. First, AHP is used to select 11 evaluation factors. Second, the target layer, criterion layer, and index layer of evaluation factors are established, then a safety evaluation factor system is formed. The three-scale AHP model is used to determine the weight of assessment indexes. Third, through the fuzzy comprehensive AHP evaluation model, the fuzzy hierarchical comprehensive evaluation is carried out for the safety assessment index system. Finally, the fuzzy comprehensive evaluation method is applied to the engineering example of a municipal road undercrossing an existing expressway bridge. The comprehensive safety evaluation of the existing bridge reflects the practicability and feasibility of the method. It is expected that, with further development, the method will improve the decision-making process in bridge safety assessment systems.

scholarly journals Development and Validation of a Post-Earthquake Safety Assessment System for High-Rise Buildings Using Acceleration Measurements

Mathematics ◽  
2021 ◽  
Vol 9 (15) ◽  
pp. 1758
Author(s):  
Koji Tsuchimoto ◽  
Yasutaka Narazaki ◽  
Billie F. Spencer
Keyword(s):  
Safety Assessment ◽  
Large Scale ◽  
Model Updating ◽  
Safety Evaluation ◽  
Assessment System ◽  
Shaking Table ◽  
Structural Safety ◽  
High Rise ◽  
Steel Building ◽  
Earthquake Safety

After a major seismic event, structural safety inspections by qualified experts are required prior to reoccupying a building and resuming operation. Such manual inspections are generally performed by teams of two or more experts and are time consuming, labor intensive, subjective in nature, and potentially put the lives of the inspectors in danger. The authors reported previously on the system for a rapid post-earthquake safety assessment of buildings using sparse acceleration data. The proposed framework was demonstrated using simulation of a five-story steel building modeled with three-dimensional nonlinear analysis subjected to historical earthquakes. The results confirmed the potential of the proposed approach for rapid safety evaluation of buildings after seismic events. However, experimental validation on large-scale structures is required prior to field implementation. Moreover, an extension to the assessment of high-rise buildings, such as those commonly used for residences and offices in modern cities, is needed. To this end, a 1/3-scale 18-story experimental steel building tested on the shaking table at E-Defense in Japan is considered. The importance of online model updating of the linear building model used to calculate the Damage Sensitive Features (DSFs) during the operation is also discussed. Experimental results confirm the efficacy of the proposed approach for rapid post-earthquake safety evaluation for high-rise buildings. Finally, a cost-benefit analysis with respect to the number of sensors used is presented.

Structural Safety Assessment of a 1100 TEU Container Ship, Based on a Enhanced Long Term Fatigue Analysis

2014 ◽  
Vol 1036 ◽  
pp. 935-940
Author(s):  
Leonard Domnisoru ◽  
Ionica Rubanenco ◽  
Mihaela Amoraritei
Keyword(s):  
Safety Assessment ◽  
Safety Evaluation ◽  
Irregular Waves ◽  
Structural Safety ◽  
Random Wave ◽  
Wave Loads ◽  
Strength Assessment ◽  
Integrated Method ◽  
Hydroelastic Response

This paper is focused on an enhanced integrated method for structural safety assessment of maritime ships under extreme random wave loads. In this study is considered an 1100 TEU container test ship, with speed range 0 to 18 knots. The most comprehensive criteria for ships structural safety evaluation over the whole exploitation life is based on the long term ship structures analysis, that includes: stress hot-spots evaluation by 3D/1D-FEM hull models, computation of short term ship dynamic response induced by irregular waves, long term fatigue structure assessment. The analysis is enhanced by taking into account the ships speed influence on hydroelastic response. The study includes a comparative analysis on two scenarios for the correlation between the ships speed and waves intensity. The standard constant ship speed scenario and CENTEC scenario, with total speed loss at extreme waves condition, are considered. Instead of 20 years ship exploitation life estimated by classification societies rules from the long term structural safety criteria, the enhanced method has predicted more restrictive values of 14.4-15.7 years. The numerical analyses are based on own software and user subroutines. The study made possible to have a more realistic approach of ships structural strength assessment, for elastic and faster ships as container carriers, in compare to the standard one based only on naval rules, delivering a method with higher confidence in the designed structural safety.

scholarly journals Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Dong Li ◽  
Aixin Li ◽  
Hairui Zhou ◽  
Xi Wang ◽  
Peng Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Side Effect ◽  
Chemical Structure ◽  
Safety Evaluation ◽  
Underlying Mechanism ◽  
Mapk Signaling ◽  
Drug Induced ◽  
Drug List ◽  
Rare Side Effect

Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space. Some key features are enriched from each of analysis. Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives. The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM. Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway enriched based on transcriptomic analysis may explain the underlying mechanism of DIM. Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.

Potential Role of Darvyadi Kwatha in the Management of Diabetes

The Healer ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 80-86
Author(s):  
Shankar Gautam ◽  
Abhishek Upadhyay ◽  
Rashmi Mutha ◽  
BINOD KUMAR SINGH ◽  
Ram Kishor Joshi
Keyword(s):  
Causes Of Death ◽  
Potential Role ◽  
Critical Role ◽  
Animal Experiments ◽  
Safety Evaluation ◽  
New Drugs ◽  
Effective Management ◽  
The Individual ◽  
Glucose 6 Phosphate Dehydrogenase

Diabetes is a clinical condition characterized by a spike in blood glucose in plasma. It is one of the 21st century's greatest public health crises and is among the top 10 causes of death worldwide. Although new drugs and therapeutics are emerging for its management but the prevalence is increasing at an alarming pace; thus, every system must contribute for effective management. An effort is made to review the efficacy and safety evaluation of the individual herbs of Darvyadi Kwatha (DK), an Ayurvedic formulation mentioned in Charaka Samhita. The constituents of the DK has some strong efficient antidiabetic/hypoglycaemic chemical principle having insulin-triggering and insulin-like behaviors which increases the activity of glucose-6-phosphate dehydrogenase (G6PD) and glucokinase and decreases glucose-6-phosphatase activity, reduce oxidative stress and prevention of glutathione reductase, superoxide dismutase, and catalase activity play a critical role in glucose homeostasis. DK also improve biochemical parameters such as SGPT, SGOT, cholesterol and triglycerides and is found to be safe in animal experiments. The various evidences clearly indicates that DK has definite hypoglycemic potential as well as anti-diabetic activity.

Sign in / Sign up

Export Citation Format

Share Document