Fabrication of gold nanocages and nanoshells using lanreotide acetate and a comparison study of their photothermal antitumor therapy

2017 ◽  
Vol 5 (28) ◽  
pp. 5641-5647 ◽  
Author(s):  
Weili Xue ◽  
Liyao Luo ◽  
Yanji Li ◽  
Tian Yin ◽  
Kexin Bian ◽  
...  
Keyword(s):  
Self Assembly ◽  
Gold Nanoshells ◽  
Comparison Study ◽  
Antitumor Therapy ◽  
Gold Nanocages

Functional gold nanoshells and nanocages were synthesized via self-assembly of lanreotide acetate.

Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy

2016 ◽  
Vol 8 (21) ◽  
pp. 13262-13269 ◽  
Author(s):  
Ruiyun Zhang ◽  
Ruirui Xing ◽  
Tifeng Jiao ◽  
Kai Ma ◽  
Chengjun Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antitumor Therapy ◽  
Carrier Free

Preparation and characterization of polymeric thin films containing gold nanoshells via electrostatic layer-by-layer self-assembly

2014 ◽  
Vol 558 ◽  
pp. 200-207 ◽  
Author(s):  
Sang Ho Lee ◽  
Andrew C. Jamison ◽  
David M. Hoffman ◽  
Allan J. Jacobson ◽  
T. Randall Lee
Keyword(s):  
Thin Films ◽  
Self Assembly ◽  
Gold Nanoshells ◽  
Layer By Layer ◽  
Polymeric Thin Films

scholarly journals Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14347-14356 ◽  
Author(s):  
Yan Wen ◽  
Wei Zhang ◽  
Ningqiang Gong ◽  
Yi-Feng Wang ◽  
Hong-Bo Guo ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Self Assembly ◽  
Chlorin E6 ◽  
Antitumor Therapy ◽  
Carrier Free ◽  
Pure Drug ◽  
Self Assembled

Carrier-free nanodrug HCPT/Ce6 NRs were prepared through a simple self-assembly approach for chemo-photodynamic combination therapy of tumors in vivo.

Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy

2017 ◽  
Vol 139 (5) ◽  
pp. 1921-1927 ◽  
Author(s):  
Qianli Zou ◽  
Manzar Abbas ◽  
Luyang Zhao ◽  
Shukun Li ◽  
Guizhi Shen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antitumor Therapy

scholarly journals Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2628
Author(s):  
Ana L. Durán-Meza ◽  
Martha I. Escamilla-Ruiz ◽  
Xochitl F. Segovia-González ◽  
Maria V. Villagrana-Escareño ◽  
J. Roger Vega-Acosta ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Surface Charge ◽  
Gold Nanorods ◽  
Self Assembly ◽  
Ostwald Ripening ◽  
Gold Nanoshells ◽  
Medical Applications ◽  
Cowpea Chlorotic Mottle Virus ◽  
Chlorotic Mottle Virus ◽  
Chlorotic Mottle

Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications.

Gold Nanoshells Coated 5-Aminolevulinic Liposomes for Photothermal-Photodynamic Antitumor Therapy

2020 ◽  
Vol 20 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Yifei Jiang ◽  
Yang Liu ◽  
Siyuan Fang ◽  
Min Ji
Keyword(s):  
Gold Nanoshells ◽  
Antitumor Therapy

One-Step Self-Assembly of Multifunctional DNA Nanohydrogels: An Enhanced and Harmless Strategy for Guiding Combined Antitumor Therapy

2019 ◽  
Vol 11 (50) ◽  
pp. 46479-46489 ◽  
Author(s):  
Hongyan Wei ◽  
Zhao Zhao ◽  
Yimin Wang ◽  
Jiang Zou ◽  
Qingyu Lin ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antitumor Therapy ◽  
One Step

scholarly journals Theoretical and X-ray studies on the cyclisation of 1-phenyl-5-(3-aryltriaz-1-en-1-yl)-1Hpyrazole- 4-carbonitriles and 2-amino-3-(3-aryltriaz-1-en-1-yl)maleonitriles: A comparison study

2021 ◽  
Author(s):  
Amal Al-Azmi ◽  
◽  
Firas F. Awwadi ◽  
Keyword(s):  
Self Assembly ◽  
Density Functional ◽  
Phenyl Group ◽  
Intermolecular Forces ◽  
Crystalline Lattice ◽  
Comparison Study ◽  
Density Functional Theory Study ◽  
Structural Isomers ◽  
Functional Theory ◽  
X Ray

The present work investigates attempts to cyclise 1-phenyl-5-(3-aryltriaz-1-en-1-yl)-1H-pyrazole- 4-carbonitriles to the desired pyrazolo[3,4-d][1,2,3]triazinimine derivatives. The cyclisations were unfruitful, and a density functional theory study was performed. This revealed the 1-phenyl-5-(3-aryltriaz-1-en-1-yl)-1H-pyrazole-4-carbonitriles are more stable than the targeted pyrazolo[3,4-d][1,2,3]triazinimine derivatives, indicating that their cyclisation is thermodynamically disfavoured; the reactant 8c is more stable than the predicted six-membered ring products 9c by 5 kJ/mol. The effect of isomerisation of the methoxy-phenyl group in the self-assembly of 8c and 8d in the crystalline lattice was investigated. The intermolecular forces in solid state were analysed in the two structural isomers 8c and 8d using calculated HirshFeld surface; the analysis indicates that the intermolecular forces are stronger in 8c than 8d and hence 8c is denser than 8d by 0.071g/mL.

Gd3+-Ion-induced carbon-dots self-assembly aggregates loaded with a photosensitizer for enhanced fluorescence/MRI dual imaging and antitumor therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (40) ◽  
pp. 19052-19063 ◽  
Author(s):  
Yanlei Liu ◽  
Xiao Zhi ◽  
Wenxiu Hou ◽  
Fangfang Xia ◽  
Jingpu Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Carbon Dots ◽  
Multifunctional Nanoparticles ◽  
Enhanced Fluorescence ◽  
Antitumor Therapy ◽  
Dual Imaging ◽  
Tumor Theranostics

The development of multifunctional nanoparticles for tumor theranostics has become a research hotspot.

Effects of paclitaxel (PTX) prodrug-based self-assembly peptide hydrogels combined with suberoylanilide hydroxamic acid (SAHA) for PTX-resistant cancer and synergistic antitumor therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 100765-100771 ◽  
Author(s):  
Chang Shu ◽  
Eboka Majolene B. Sabi-mouka ◽  
Wen Yang ◽  
Zhongyang Li ◽  
Li Ding
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Hydroxamic Acid ◽  
Suberoylanilide Hydroxamic Acid ◽  
Antitumor Therapy ◽  
Peptide Hydrogels

Schematic illustration of PTX prodrug-based self-assembly peptide hydrogels encapsulated SAHA for drug combination.

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