Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy

2016 ◽  
Vol 8 (21) ◽  
pp. 13262-13269 ◽  
Author(s):  
Ruiyun Zhang ◽  
Ruirui Xing ◽  
Tifeng Jiao ◽  
Kai Ma ◽  
Chengjun Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antitumor Therapy ◽  
Carrier Free

scholarly journals Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14347-14356 ◽  
Author(s):  
Yan Wen ◽  
Wei Zhang ◽  
Ningqiang Gong ◽  
Yi-Feng Wang ◽  
Hong-Bo Guo ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Self Assembly ◽  
Chlorin E6 ◽  
Antitumor Therapy ◽  
Carrier Free ◽  
Pure Drug ◽  
Self Assembled

Carrier-free nanodrug HCPT/Ce6 NRs were prepared through a simple self-assembly approach for chemo-photodynamic combination therapy of tumors in vivo.

Carrier-Free, Pure Nanodrug Formed by the Self-Assembly of an Anticancer Drug for Cancer Immune Therapy

2018 ◽  
Vol 15 (6) ◽  
pp. 2466-2478 ◽  
Author(s):  
Lulu Fan ◽  
Bingchen Zhang ◽  
Aixiao Xu ◽  
Zhichun Shen ◽  
Yan Guo ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Self Assembly ◽  
Immune Therapy ◽  
The Self ◽  
Carrier Free

Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy

2017 ◽  
Vol 139 (5) ◽  
pp. 1921-1927 ◽  
Author(s):  
Qianli Zou ◽  
Manzar Abbas ◽  
Luyang Zhao ◽  
Shukun Li ◽  
Guizhi Shen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antitumor Therapy

Acidity-responsive shell-sheddable camptothecin-based nanofibers for carrier-free cancer drug delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (34) ◽  
pp. 15907-15916 ◽  
Author(s):  
Zhuha Zhou ◽  
Ying Piao ◽  
Lingqiao Hao ◽  
Guanyu Wang ◽  
Zhuxian Zhou ◽  
...  
Keyword(s):  
Self Assembly ◽  
Surface Coating ◽  
Tumor Tissue ◽  
The Self ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Carrier Free ◽  
Cancer Drug Delivery

pH-responsive nanofibers are obtained by the self-assembly of the camptothecin prodrug and surface-coating, which can efficiently enter cancer cells in vitro and penetrate deep into tumor tissue in vivo.

scholarly journals Turing miRNA into infinite coordination supermolecule: a general and enabling nanoengineering strategy for resurrecting nuclear acid therapeutics

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Liya Li ◽  
Wangxiao He ◽  
Weiming You ◽  
Jin Yan ◽  
Wenjia Liu
Keyword(s):  
Self Assembly ◽  
Wnt Signaling Pathway ◽  
Pdx Model ◽  
Carrier Free ◽  
Rapid Clearance ◽  
Targeting Ability ◽  
Time Injection ◽  
General Method

Abstract Background Clinical translation of therapeutic nuclear acid, particularly those targeting tumor progression, has been hampered by the intrinsic weaknesses of nuclear acid therapeutic including poor systemic stability, rapid clearance, low membrane permeability and lack of targeting ability. Small nuclear acid engineered into carrier-free nanodrugs with structural stability and disease targeting may be viable to overcome pharmaceutical obstacles of nuclear acid. Methods A general method through a mild and simple chemistry was established to convert therapeutic miRNA into an infinite Auric-sulfhydryl coordination supramolecular miRNA termed IacsRNA with near-spherical nanostructure, high colloid as well as anti-hydrolysis stability and low macrophage uptakes. Results IacsRNA presented the increased half-life period in circulation and accumulation at tumor sites in comparison to normal miRNA. Moreover, Iacs-miR-30c showed no toxicity of viscera and sanguis system in the 5-time injection dosage of the treatment. More importantly, Iacs-miR-30c potently suppressed the Wnt signaling pathway in vitro and in vivo, and effectively sensitized both potency of 5-Fu in PDX model of colon cancer and Anti-PD1 in B16F10 homograft model of melanoma. Conclusion Collectively, this work amply confirmed the design of IacsRNA as a general and viable strategy of nano-pharmaceutic to concert flimsy therapeutic miRNA into potential drugs. Considering from a broader perspective, the miRNA-initiated infinite coordination self-assembly strategy has distinct advantages in resurrecting nuclear acid therapeutics, probably bringing new inspiration to RNA-derived therapeutics of a great variety of human diseases including cancer. Graphical Abstract

Development of carrier-free nanodrugs based on low molecular heparin-doxorubicin conjugate assembly with smart pH-triggered drug release characteristics for combinatorial antitumor therapy

2021 ◽  
Author(s):  
Bo Fan ◽  
Qian Li ◽  
Yanping Jiang ◽  
Weiguang Shen ◽  
Yang Xing ◽  
...  
Keyword(s):  
Drug Release ◽  
Solid Tumors ◽  
Single Treatment ◽  
Antitumor Therapy ◽  
Carrier Free ◽  
Triggered Drug Release

Abnormal angiogenesis is a hallmark of solid tumors. The combination of cytotoxic and anti-angiogenic drugs has been proved to be more effective than single treatment. As a shining platform, the...

Fabrication of gold nanocages and nanoshells using lanreotide acetate and a comparison study of their photothermal antitumor therapy

2017 ◽  
Vol 5 (28) ◽  
pp. 5641-5647 ◽  
Author(s):  
Weili Xue ◽  
Liyao Luo ◽  
Yanji Li ◽  
Tian Yin ◽  
Kexin Bian ◽  
...  
Keyword(s):  
Self Assembly ◽  
Gold Nanoshells ◽  
Comparison Study ◽  
Antitumor Therapy ◽  
Gold Nanocages

Functional gold nanoshells and nanocages were synthesized via self-assembly of lanreotide acetate.

Tumor acidity-responsive carrier-free nanodrugs based on targeting activation via ICG-templated assembly for NIR-II imaging-guided photothermal–chemotherapy

2021 ◽  
Author(s):  
Kaihang Xue ◽  
Feng Wei ◽  
Jinyan Lin ◽  
Haina Tian ◽  
Fukai Zhu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Small Molecule ◽  
Self Assembly ◽  
Tumor Acidity ◽  
Carrier Free

Novel tumor microenvironment-driven self-targeting supramolecular nanodrugs via ICG-templated small-molecule self-assembly for NIR-II imaging-guided synergistic photothermal–chemotherapy.

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