scholarly journals Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy

2017 ◽  
Vol 5 (23) ◽  
pp. 4421-4425 ◽  
Author(s):  
Elizabeth Ellis ◽  
Kangyi Zhang ◽  
Qianyu Lin ◽  
Enyi Ye ◽  
Alessandro Poma ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Drug Efficacy ◽  
Multilayer Shell ◽  
Ph Responsive ◽  
Drug Nanocarriers ◽  
Excellent Stability

pH-Responsive drug nanocarriers were made via facile self-assembly, showing excellent stability in bio-media (50% PBS/FBS) and enhanced drug efficacy towards cancer cells.

Self-assembled nanodiamond supraparticles for anticancer chemotherapy

Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 8969-8978 ◽  
Author(s):  
Yue Yu ◽  
Masahiro Nishikawa ◽  
Ming Liu ◽  
Takahiro Tei ◽  
Sunil C. Kaul ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Drug Efficacy ◽  
Anticancer Chemotherapy ◽  
Self Assembled

Chemically functionalized nanodiamonds (NDs) were transformed into supraparticle (SP) nanoclusters via self-assembly. The ND–SP nanoclusters were biocompatible and internalized by cancer cells, and markedly enhanced anticancer drug efficacy compared to conventional nanomedicines.

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

2010 ◽  
Vol 21 (3) ◽  
pp. 496-504 ◽  
Author(s):  
Xiaoqiang Yang ◽  
Jamison J. Grailer ◽  
Srikanth Pilla ◽  
Douglas A. Steeber ◽  
Shaoqin Gong
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Targeted Cancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

scholarly journals Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Wooram Park ◽  
Sin-jung Park ◽  
Heejun Shin ◽  
Kun Na
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Ph Responsive ◽  
Imine Group ◽  
Tumor Ph ◽  
Methoxypolyethylene Glycol ◽  
Photodynamic Cancer Therapy ◽  
Cervical Cancer Cells ◽  
Targeted Photodynamic Therapy

An acidic tumor pH-responsive nanophotomedicine (pH-NanoPM) for targeted photodynamic therapy (PDT) was demonstrated herein. The pH-NanoPM was prepared with a size of ~110 nm by self-assembly of a pH-responsive polymeric photosensitizer (pH-PPS) consisting of pH-cleavable methoxypolyethylene glycol (pH-C-mPEG). Because the pH-C-mPEG can be detached from the nanoparticles by hydrolysis of the benzoic-imine group at the pH of an acidic tumor (~6.5), the particle size and surface charge of the pH-NanoPM were changed along with the environmental pH condition. After detachment of the pH-C-mPEG, the pH-NanoPM particles became positively charged (+18.67±1.95 mV) due to exposure of primary amine groups and decreased to a size of ~40 nm. Fromin vitrocellular experiments with HeLa human cervical cancer cells, the pH-NanoPM exhibited enhanced cellular internalization at acidic tumor pH compared to normal pH, which led to a significant cancer cell killing effect. These results suggest that this system has the potential to be used as a new class of nanophotomedicine for targeted photodynamic cancer therapy.

A self-assembly of an active tumor-targeted photothermal agent for enhanced anti-inflammatory cancer therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18021-18025 ◽  
Author(s):  
Hongyu Wang ◽  
Jinjie Chang ◽  
Wei Pan ◽  
Na Li ◽  
Bo Tang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Self Assembly ◽  
Inflammatory Responses ◽  
Anti Inflammatory

A self-assembly of an active tumor-targeted organic photothermal agent, functionalized with a cyclic Arg-Gly-Asp (cRGD) peptide and ibuprofen, for efficiently killing cancer cells and eliciting anti-inflammatory responses was successfully developed.

Synthesis, self-assembly, and pH-responsive drug release of PHMEMA-PEG-PHMEMA ABA triblock copolymers

2018 ◽  
Vol 55 (10) ◽  
pp. 691-697 ◽  
Author(s):  
Qingqing Pan ◽  
Zhihui Zong ◽  
Jingyi Shen ◽  
Hongbao Xue ◽  
Yuji Pu
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Ph Responsive

Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells

2019 ◽  
Vol 7 (5) ◽  
pp. 2102-2122 ◽  
Author(s):  
Sandhra M. Carvalho ◽  
Alice G. Leonel ◽  
Alexandra A. P. Mansur ◽  
Isadora C. Carvalho ◽  
Klaus Krambrock ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Brain Cancer ◽  
Oxide Nanoparticles ◽  
Drug Nanocarriers

Magnetopolymersomes for potential multimodal brain cancer therapy – “nanoheaters meet drug nanocarriers”.

Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel

2017 ◽  
Vol 8 (40) ◽  
pp. 6289-6299 ◽  
Author(s):  
Manuela Callari ◽  
Sandy Wong ◽  
Hongxu Lu ◽  
Janice Aldrich-Wright ◽  
Paul de Souza ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Drug Carriers ◽  
Multi Drug Resistance ◽  
Platinum Drugs ◽  
Drug Induced ◽  
Dual Drug

Co-delivery of two drugs in one nanoparticle is increasingly used to overcome, for example, multi-drug resistance in cancer therapy and therefore suitable drug carriers need to be developed.

Synthesis, characterization and pH-Responsive self-assembly behavior of amphiphilic multiarm star triblock copolymers based on PCL, PDEAEMA, and PEG

2013 ◽  
Vol 21 (9) ◽  
pp. 1011-1020 ◽  
Author(s):  
You Qiang Yang ◽  
Wen Jing Lin ◽  
Li Juan Zhang ◽  
Cheng Zhi Cai ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triblock Copolymers ◽  
Ph Responsive ◽  
Assembly Behavior

Unimolecular micelles of pH-responsive star-like copolymers for co-delivery of anticancer drugs and small-molecular photothermal agents: a new drug-carrier for combinational chemo/photothermal cancer therapy

2017 ◽  
Vol 5 (43) ◽  
pp. 8514-8524 ◽  
Author(s):  
Tao Jia ◽  
Shuo Huang ◽  
Cangjie Yang ◽  
Mingfeng Wang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Drug Carrier ◽  
Ph Responsive ◽  
New Drug

Robust unimolecular micelles of amphiphilic pH-responsive starlike copolymers that carry anticancer drugs and photothermal agents show enhanced therapeutic effect against cancer cells.

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